DR 2313

Discontinued Product

DR 2313 (Cat. No. 2496) has been withdrawn from sale for commercial reasons.
Description: PARP-1 and PARP-2 inhibitor
Chemical Name: 1,5,7,8-Tetrahydro-2-methyl-4H-thiopyrano[4,3-d]pyrimidin-4-one
Purity: ≥99% (HPLC)
Literature (2)

Biological Activity for DR 2313

DR 2313 is a competitive inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50 values are 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). Neuroprotective; reduces neuronal cell death in models of cerebral ischemia in vivo and in vitro. Brain penetrant.

Technical Data for DR 2313

M. Wt 182.24
Formula C8H10N2OS
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 284028-90-6
PubChem ID 10219702
Smiles CC1=NC(=O)C2=C(N1)CCSC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for DR 2313

References are publications that support the biological activity of the product.

Nakajima et al (2005) A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-Methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats. J.Pharmacol.Exp.Ther. 312 472 PMID: 15466246

Jagtap and Szabo (2005) Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat.Rev.Drug Discov. 4 421 PMID: 15864271

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Keywords: DR 2313, DR 2313 supplier, Potent, PARP, inhibitors, inhibits, PolyADP-ribose, Polymerase, Polymerases, DR2313, Poly(ADP-ribose), 2496, Tocris Bioscience

Citations for DR 2313

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Currently there are no citations for DR 2313.

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Literature in this Area

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