DR 2313

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Cat.No. 2496 - DR 2313 | C8H10N2OS | CAS No. 284028-90-6
Description: PARP-1 and PARP-2 inhibitor
Chemical Name: 1,5,7,8-Tetrahydro-2-methyl-4H-thiopyrano[4,3-d]pyrimidin-4-one
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Competitive inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50 values are 0.20 and 0.24 μM for PARP-1 and PARP-2 respectively). Neuroprotective; reduces neuronal cell death in models of cerebral ischemia in vivo and in vitro. Brain penetrant.

Technical Data

M. Wt 182.24
Formula C8H10N2OS
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 284028-90-6
PubChem ID 10219702
InChI Key HRYKZAKEAVZGJD-UHFFFAOYSA-N
Smiles CC1=NC(=O)C2=C(N1)CCSC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 7.29 40

Preparing Stock Solutions

The following data is based on the product molecular weight 182.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.49 mL 27.44 mL 54.87 mL
5 mM 1.1 mL 5.49 mL 10.97 mL
10 mM 0.55 mL 2.74 mL 5.49 mL
50 mM 0.11 mL 0.55 mL 1.1 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Nakajima et al (2005) A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-Methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats. J.Pharmacol.Exp.Ther. 312 472 PMID: 15466246

Jagtap and Szabo (2005) Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat.Rev.Drug Discov. 4 421 PMID: 15864271


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Keywords: Potent PARP inhibitors inhibits PolyADP-ribose Polymerase Polymerases DR2313 Poly(ADP-ribose) Polymerase

Citations for DR 2313

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Literature in this Area

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