Discontinued Product

DPNB-ABT 594 (Cat. No. 6706) has been withdrawn from sale for commercial reasons.
Description: Caged ABT 594 (Cat. No. 6576); suitable for one- or two-photon photolysis
Chemical Name: 5-(((2R)-1-(1-(4,5-Bis(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-2-nitrophenyl)ethyl)azetidin-2-yl)methoxy)-2-chloropyridine
Purity: ≥98% (HPLC)

Biological Activity for DPNB-ABT 594

DPNB-ABT 594 is a nitrobenzyl-caged ABT 594 (Cat. No. 6576), a selective α4β2 nAChR agonist. One-photon uncaging evokes large inward currents and Ca2+ transients on cell bodies and dendrites of medial habenular neurons in mouse brain slices. Two-photon uncaging induces fast nAChR-mediated currents. Photolyzed with high quantum yield of 0.20. Effective photolysis occurs using one- or two-photon excitation; one-photon uncaging requires illumination at 410 nm for 1.5-3 ms; two-photon uncaging requires illumination with appropriate two photon pulse laser at 710 nm for ~2 ms.

Technical Data for DPNB-ABT 594

M. Wt 672.16
Formula C31H46ClN3O11
Storage Store at -20°C
Purity ≥98% (HPLC)

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for DPNB-ABT 594

References are publications that support the biological activity of the product.

Passlick et al (2018) Optical probing of acetylcholine receptors on neurons in the medial habenula with a novel caged nicotine drug analogue. J.Physiol. 596 5307 PMID: 30222192

Keywords: DPNB-ABT 594, DPNB-ABT 594 supplier, caged, agonists, ABT, 594, photoactivatable, nicotine, nicotinics, cholinergics, activators, acetylcholine, receptors, nAChRs, a4b2, Nicotinic, (a4b2), Receptors, Caged, Compounds, 6706, Tocris Bioscience

Citations for DPNB-ABT 594

Citations are publications that use Tocris products.

Currently there are no citations for DPNB-ABT 594.

Reviews for DPNB-ABT 594

There are currently no reviews for this product. Be the first to review DPNB-ABT 594 and earn rewards!

Have you used DPNB-ABT 594?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review