You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Nitrobenzyl-caged ABT 594 (Cat. No. 6576), a selective α4β2 nAChR agonist. Suitable for one- or two-photon photolysis. Evokes large inward currents and Ca2+ transients on cell bodies and dendrites of medial habenular neurons in mouse brain slices, following exposure to 410 nm light. Two-photon uncaging at 720 nm induces fast nAChR-mediated currents. Photolyzed with high quantum yield of 0.20.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 672.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.49 mL||7.44 mL||14.88 mL|
|5 mM||0.3 mL||1.49 mL||2.98 mL|
|10 mM||0.15 mL||0.74 mL||1.49 mL|
|50 mM||0.03 mL||0.15 mL||0.3 mL|
References are publications that support the biological activity of the product.
Passlick et al (2018) Optical probing of acetylcholine receptors on neurons in the medial habenula with a novel caged nicotine drug analogue. J.Physiol. 596 5307 PMID: 30222192
If you know of a relevant reference for DPNB-ABT 594, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: DPNB-ABT 594, DPNB-ABT 594 supplier, caged, agonists, ABT, 594, photoactivatable, nicotine, nicotinics, cholinergics, activators, acetylcholine, receptors, nAChRs, a4b2, Nicotinic, (a4b2), Receptors, Other, Caged, Compounds, 6706, Tocris Bioscience
Citations for DPNB-ABT 594
Citations are publications that use Tocris products.
Currently there are no citations for DPNB-ABT 594. Do you know of a great paper that uses DPNB-ABT 594 from Tocris? Please let us know.
Reviews for DPNB-ABT 594
There are currently no reviews for this product. Be the first to review DPNB-ABT 594 and earn rewards!
Have you used DPNB-ABT 594?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.