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Submit ReviewDPNB-ABT 594
Description: Caged ABT 594 (Cat. No. 6576); suitable for one- or two-photon photolysis
Chemical Name: 5-(((2R)-1-(1-(4,5-Bis(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-2-nitrophenyl)ethyl)azetidin-2-yl)methoxy)-2-chloropyridine
Purity: ≥98% (HPLC)
Biological Activity for DPNB-ABT 594
DPNB-ABT 594 is a nitrobenzyl-caged ABT 594 (Cat. No. 6576), a selective α4β2 nAChR agonist. One-photon uncaging evokes large inward currents and Ca2+ transients on cell bodies and dendrites of medial habenular neurons in mouse brain slices. Two-photon uncaging induces fast nAChR-mediated currents. Photolyzed with high quantum yield of 0.20. Effective photolysis occurs using one- or two-photon excitation; one-photon uncaging requires illumination at 410 nm for 1.5-3 ms; two-photon uncaging requires illumination with appropriate two photon pulse laser at 710 nm for ~2 ms.
Technical Data for DPNB-ABT 594
| M. Wt | 672.16 |
| Formula | C31H46ClN3O11 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| Smiles | ClC1=NC=C(C=C1)OC[C@@H]2CCN2C(C)C3=CC(OCCOCCOCCOC)=C(OCCOCCOCCOC)C=C3[N+]([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for DPNB-ABT 594
References for DPNB-ABT 594
References are publications that support the biological activity of the product.
Passlick et al (2018) Optical probing of acetylcholine receptors on neurons in the medial habenula with a novel caged nicotine drug analogue. J.Physiol. 596 5307 PMID: 30222192
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