DPNB-ABT 594

Cat. No. 6706 Submit a Review Datasheet / COA / SDS

Pricing	Availability		Qty

Bulk Orders

Description: Caged ABT 594 (Cat. No. 6576); suitable for one- or two-photon photolysis

Chemical Name: 5-(((2R)-1-(1-(4,5-Bis(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-2-nitrophenyl)ethyl)azetidin-2-yl)methoxy)-2-chloropyridine

Purity: ≥98% (HPLC)

Datasheet

Citations

Reviews

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for DPNB-ABT 594

DPNB-ABT 594 is a nitrobenzyl-caged ABT 594 (Cat. No. 6576), a selective α4β2 nAChR agonist. One-photon uncaging evokes large inward currents and Ca²⁺ transients on cell bodies and dendrites of medial habenular neurons in mouse brain slices. Two-photon uncaging induces fast nAChR-mediated currents. Photolyzed with high quantum yield of 0.20. Effective photolysis occurs using one- or two-photon excitation; one-photon uncaging requires illumination at 410 nm for 1.5-3 ms; two-photon uncaging requires illumination with appropriate two photon pulse laser at 710 nm for ~2 ms.

Technical Data for DPNB-ABT 594

M. Wt	672.16
Formula	C₃₁H₄₆ClN₃O₁₁
Storage	Store at -20°C
Purity	≥98% (HPLC)
Smiles	ClC1=NC=C(C=C1)OC[C@@H]2CCN2C(C)C3=CC(OCCOCCOCCOC)=C(OCCOCCOCCOC)C=C3[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DPNB-ABT 594

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	67.22	100
	ethanol	67.22	100

Preparing Stock Solutions for DPNB-ABT 594

The following data is based on the product molecular weight 672.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.49 mL	7.44 mL	14.88 mL
5 mM	0.3 mL	1.49 mL	2.98 mL
10 mM	0.15 mL	0.74 mL	1.49 mL
50 mM	0.03 mL	0.15 mL	0.3 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

Product Datasheets for DPNB-ABT 594

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for DPNB-ABT 594

References are publications that support the biological activity of the product.

Passlick et al (2018) Optical probing of acetylcholine receptors on neurons in the medial habenula with a novel caged nicotine drug analogue. J.Physiol. 596 5307 PMID: 30222192

If you know of a relevant reference for DPNB-ABT 594, please let us know.

View Related Products by Target

Keywords: DPNB-ABT 594, DPNB-ABT 594 supplier, caged, agonists, ABT, 594, photoactivatable, nicotine, nicotinics, cholinergics, activators, acetylcholine, receptors, nAChRs, a4b2, Nicotinic, (a4b2), Receptors, Caged, Compounds, 6706, Tocris Bioscience

Citations for DPNB-ABT 594

Citations are publications that use Tocris products.

Currently there are no citations for DPNB-ABT 594. Do you know of a great paper that uses DPNB-ABT 594 from Tocris? Please let us know.

Reviews for DPNB-ABT 594

There are currently no reviews for this product. Be the first to review DPNB-ABT 594 and earn rewards!

Have you used DPNB-ABT 594?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review