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Cat.No. 6706 - DPNB-ABT 594 | C31H46ClN3O11
Description: Caged ABT 594; suitable for one- or two-photon photolysis
Chemical Name: 5-(((2R)-1-(1-(4,5-Bis(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)-2-nitrophenyl)ethyl)azetidin-2-yl)methoxy)-2-chloropyridine
Purity: ≥98% (HPLC)

Biological Activity

Nitrobenzyl-caged ABT 594 (Cat. No. 6576), a selective α4β2 nAChR agonist. Suitable for one- or two-photon photolysis. Evokes large inward currents and Ca2+ transients on cell bodies and dendrites of medial habenular neurons in mouse brain slices, following exposure to 410 nm light. Two-photon uncaging at 720 nm induces fast nAChR-mediated currents. Photolyzed with high quantum yield of 0.20.

Technical Data

M. Wt 672.16
Formula C31H46ClN3O11
Storage Store at -20°C
Purity ≥98% (HPLC)

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 67.22 100
ethanol 67.22 100

Preparing Stock Solutions

The following data is based on the product molecular weight 672.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.49 mL 7.44 mL 14.88 mL
5 mM 0.3 mL 1.49 mL 2.98 mL
10 mM 0.15 mL 0.74 mL 1.49 mL
50 mM 0.03 mL 0.15 mL 0.3 mL

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References are publications that support the biological activity of the product.

Passlick et al (2018) Optical probing of acetylcholine receptors on neurons in the medial habenula with a novel caged nicotine drug analogue. J.Physiol. 596 5307 PMID: 30222192

If you know of a relevant reference for DPNB-ABT 594, please let us know.

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