Doxercalciferol

Pricing Availability   Qty
Cat.No. 3206 - Doxercalciferol | C28H44O2 | CAS No. 54573-75-0
Description: Vitamin D2 analog, VDR agonist
Chemical Name: (1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-7α-methyl-1-[(1R,2E)-1,4,5-trimethyl-2-hexen-1-yl]-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity

Vitamin D2 analog that acts as a vitamin D receptor activator (VDRA).

Technical Data

M. Wt 412.65
Formula C28H44O2
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 54573-75-0
PubChem ID 5281107
InChI Key HKXBNHCUPKIYDM-CGMHZMFXSA-N
Smiles C[C@@](CCC2)3[C@](CC[C@@]([H])3[C@@H](/C=C/[C@H](C)C(C)C)C)([H])/C2=C/C=C(C[C@@H](O)C[C@@H]1O)\C1=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 20.63 50
DMSO 4.13 10

Preparing Stock Solutions

The following data is based on the product molecular weight 412.65. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.85 mL 24.23 mL 48.47 mL
2.5 mM 0.97 mL 4.85 mL 9.69 mL
5 mM 0.48 mL 2.42 mL 4.85 mL
25 mM 0.1 mL 0.48 mL 0.97 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Brown et al (2006) The vitamin D prodrugs 1α(OH)D2, 1α(OH)D3 and BCI-210 suppress PTH secretion by bovine parathyriod cells. Nephrol.Dial.Transplant. 21 644 PMID: 16221703

Noonan et al (2008) Differential effects of vitamin D receptor activators on aortic calcification and pulse wave velocity in uraemic rats. Nephrol.Dial.Transplant. 23 3824 PMID: 18644798


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Keywords: Doxercalciferol, Doxercalciferol supplier, Vitamin, D2, VDR, agonists, D, Receptors, VDR-like, 3206, Tocris Bioscience

Citations for Doxercalciferol

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Literature in this Area

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