Doxepin hydrochloride

Discontinued Product

Doxepin hydrochloride (Cat. No. 0508) has been withdrawn from sale for commercial reasons.
Cat.No. 0508 - Doxepin hydrochloride | C19H21NO.HCl | CAS No. 1229-29-4
Description: Highly potent H1 antagonist. Also binds to H4 receptor
Chemical Name: 11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin hydrochloride
Purity: ≥99% (HPLC)
Citations (1)
Literature (3)

Biological Activity

Highly potent H1 histamine receptor antagonist (Kd = 310 pM) and tricyclic antidepressant. Also binds to the H4 histamine receptor (pKi = 6.79).

This compound is a mixture of E/Z isomers (ratio: 85:15).

Technical Data

M. Wt 315.84
Formula C19H21NO.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1229-29-4
PubChem ID 5281088
Smiles Cl[H].CN(C)CC\C=C1\C2=C(COC3=C1C=CC=C3)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Lurchins (1983) Review of clinical and animal studies comparing the cardiovascular effects of dox. and other tricyclic antidepressants. Am.J.Psychiatry 140 1006 PMID: 6346907

Nguyen et al (2001) Discovery of a novel member of the histamine receptor family. Mol.Pharmacol. 59 427 PMID: 11179435

Tran et al (1981) [3H]Doxepin interactions with histamine H1-receptors and other sites in guinea pig brain homogenates. Eur.J.Pharmacol. 70 501 PMID: 7238574

Merck Index 12 3492

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Keywords: Doxepin hydrochloride, Doxepin hydrochloride supplier, potent, H1, antagonists, binds, H4, Receptors, Histamine, histaminergic, 0508, Tocris Bioscience

1 Citation for Doxepin hydrochloride

Citations are publications that use Tocris products. Selected citations for Doxepin hydrochloride include:

Jones et al (2011) Roles of affinity and lipophilicity in the slow kinetics of prostanoid receptor antagonists on isolated smooth muscle preparations. Br J Pharmacol 162 863 PMID: 20973775

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