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Highly potent H1 histamine receptor antagonist (Kd = 310 pM) and tricyclic antidepressant. Also binds to the H4 histamine receptor (pKi = 6.79).
This compound is a mixture of E/Z isomers (ratio: 85:15).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 315.84. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.17 mL||15.83 mL||31.66 mL|
|5 mM||0.63 mL||3.17 mL||6.33 mL|
|10 mM||0.32 mL||1.58 mL||3.17 mL|
|50 mM||0.06 mL||0.32 mL||0.63 mL|
References are publications that support the biological activity of the product.
Lurchins (1983) Review of clinical and animal studies comparing the cardiovascular effects of dox. and other tricyclic antidepressants. Am.J.Psychiatry 140 1006 PMID: 6346907
Nguyen et al (2001) Discovery of a novel member of the histamine receptor family. Mol.Pharmacol. 59 427 PMID: 11179435
Tran et al (1981) [3H]Doxepin interactions with histamine H1-receptors and other sites in guinea pig brain homogenates. Eur.J.Pharmacol. 70 501 PMID: 7238574
Merck Index 12 3492
If you know of a relevant reference for Doxepin hydrochloride, please let us know.
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Keywords: Doxepin hydrochloride, Doxepin hydrochloride supplier, potent, H1, antagonists, binds, H4, Receptors, Histamine, histaminergic, 0508, Tocris Bioscience
1 Citation for Doxepin hydrochloride
Citations are publications that use Tocris products. Selected citations for Doxepin hydrochloride include:
Jones et al (2011) Roles of affinity and lipophilicity in the slow kinetics of prostanoid receptor antagonists on isolated smooth muscle preparations. Br J Pharmacol 162 863 PMID: 20973775
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