Highly potent H1 histamine receptor antagonist (Kd = 310 pM) and tricyclic antidepressant. Also binds to the H4 histamine receptor (pKi = 6.79).This compound is a mixture of E/Z isomers (ratio: 85:15).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 315.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.17 mL||15.83 mL||31.66 mL|
|5 mM||0.63 mL||3.17 mL||6.33 mL|
|10 mM||0.32 mL||1.58 mL||3.17 mL|
|50 mM||0.06 mL||0.32 mL||0.63 mL|
References are publications that support the products' biological activity.
Lurchins (1983) Review of clinical and animal studies comparing the cardiovascular effects of doxepin and other tricyclic antidepressants. Am.J.Psychiatry 140 1006 PMID: 6346907
Nguyen et al (2001) Discovery of a novel member of the histamine receptor family. Mol.Pharmacol. 59 427 PMID: 11179435
Tran et al (1981) [3H]Doxepin interactions with histamine H1-receptors and other sites in guinea pig brain homogenates. Eur.J.Pharmacol. 70 501 PMID: 7238574
If you know of a relevant reference for Doxepin hydrochloride, please let us know.
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