Doxepin hydrochloride

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Cat.No. 0508 - Doxepin hydrochloride | C19H21NO.HCl | CAS No. 1229-29-4
Description: Highly potent H1 antagonist. Also binds to H4 receptor
Chemical Name: 11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin hydrochloride
Purity: ≥99% (HPLC)

Biological Activity

Highly potent H1 histamine receptor antagonist (Kd = 310 pM) and tricyclic antidepressant. Also binds to the H4 histamine receptor (pKi = 6.79).

This compound is a mixture of E/Z isomers (ratio: 85:15).

Technical Data

M. Wt 315.84
Formula C19H21NO.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1229-29-4
PubChem ID 5281088
Smiles Cl[H].CN(C)CC\C=C1\C2=C(COC3=C1C=CC=C3)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 31.58 100
water 31.58 100

Preparing Stock Solutions

The following data is based on the product molecular weight 315.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.17 mL 15.83 mL 31.66 mL
5 mM 0.63 mL 3.17 mL 6.33 mL
10 mM 0.32 mL 1.58 mL 3.17 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Lurchins (1983) Review of clinical and animal studies comparing the cardiovascular effects of doxepin and other tricyclic antidepressants. Am.J.Psychiatry 140 1006 PMID: 6346907

Nguyen et al (2001) Discovery of a novel member of the histamine receptor family. Mol.Pharmacol. 59 427 PMID: 11179435

Tran et al (1981) [3H]Doxepin interactions with histamine H1-receptors and other sites in guinea pig brain homogenates. Eur.J.Pharmacol. 70 501 PMID: 7238574

Merck Index 12 3492 PMID:

If you know of a relevant reference for Doxepin hydrochloride, please let us know.

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