DOB hydrochloride

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Cat.No. 2863 - DOB hydrochloride | C11H16BrNO2.HCl | CAS No. 29705-96-2
Description: Selective 5-HT2 agonist
Alternative Names: 2,5-Dimethoxy-4-bromoamphetamine hydrochloride
Chemical Name: 4-Bromo-2,5-dimethoxy-α-methylbenzeneethanamine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective 5-HT2 receptor agonist (Ki values are 0.44, 59, 69, 831 and 3700 nM for 5-HT2H, 5-HT2L, 5-HT2C, 5-HT1B and 5-HT1A receptors respectively). Hallucinogenic.

Technical Data

M. Wt 310.62
Formula C11H16BrNO2.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 29705-96-2
PubChem ID 12626562
InChI Key SPBBKPOIDQIWDZ-UHFFFAOYSA-N
Smiles BrC1=C(OC)C=C(CC(C)N)C(OC)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 31.06 100

Preparing Stock Solutions

The following data is based on the product molecular weight 310.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.22 mL 16.1 mL 32.19 mL
5 mM 0.64 mL 3.22 mL 6.44 mL
10 mM 0.32 mL 1.61 mL 3.22 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Titiler et al (1987) Selectivity of serotonergic drugs for multiple brain serotonin receptors. Biochem.Pharmacol. 36 3265 PMID: 3663239

Arvanov et al (1999) A pre- and postsynaptic modulatory action of 5-HT and the 5-HT2A,2C receptor agonist DOB on NMDA-evoked responses in the rat medial prefrontal cortex. Eur.J.Neurosci. 11 2917 PMID: 10457188

McKenna et al (1989) Differentiation of 5-hydroxytryptamine2 receptor subtypes using 125I-R-(-)2,5-dimethoxy-4-iodo-phenylisopropylamine and 3H-ketanserin. J.Neurosci. 10 3482 PMID:


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Keywords: Selective 5-HT2 agonists Non-Selective Serotonin Receptors 2,5-Dimethoxy-4-bromoamphetamine hydrochloride Non-selective 5-HT2

Citations for DOB hydrochloride

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Literature in this Area

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Pathways for DOB hydrochloride

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