Selective 5-HT2 receptor agonist (Ki values are 0.44, 59, 69, 831 and 3700 nM for 5-HT2H, 5-HT2L, 5-HT2C, 5-HT1B and 5-HT1A receptors respectively). Hallucinogenic.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 310.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.22 mL||16.1 mL||32.19 mL|
|5 mM||0.64 mL||3.22 mL||6.44 mL|
|10 mM||0.32 mL||1.61 mL||3.22 mL|
|50 mM||0.06 mL||0.32 mL||0.64 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Titiler et al (1987) Selectivity of serotonergic drugs for multiple brain serotonin receptors. Biochem.Pharmacol. 36 3265 PMID: 3663239
Arvanov et al (1999) A pre- and postsynaptic modulatory action of 5-HT and the 5-HT2A,2C receptor agonist DOB on NMDA-evoked responses in the rat medial prefrontal cortex. Eur.J.Neurosci. 11 2917 PMID: 10457188
If you know of a relevant reference for DOB hydrochloride, please let us know.
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Keywords: Selective 5-HT2 agonists Non-Selective Serotonin Receptors 2,5-Dimethoxy-4-bromoamphetamine hydrochloride Non-selective 5-HT2
Citations for DOB hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for DOB hydrochloride. Do you know of a great paper that uses DOB hydrochloride from Tocris? If so please let us know.
Literature in this Area
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.