DNQX disodium salt
Biological Activity
Water-soluble form of DNQX (Cat. No. 0189). Selective non-NMDA receptor antagonist.
Technical Data
| M. Wt | 296.1 |
| Formula | C8H2N4O6Na2 |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1312992-24-7 |
| PubChem ID | 45073428 |
| InChI Key | GPSBSOYURFUVKJ-UHFFFAOYSA-L |
| Smiles | [Na+].[Na+].[O-]C1=C([O-])N=C2C=C(C(=CC2=N1)[N+]([O-])=O)[N+]([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 31.4 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 296.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.38 mL | 16.89 mL | 33.77 mL |
| 5 mM | 0.68 mL | 3.38 mL | 6.75 mL |
| 10 mM | 0.34 mL | 1.69 mL | 3.38 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
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References
References are publications that support the products' biological activity.
Honore et al (1988) Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science 241 701 PMID: 2899909
Watkins et al (1990) Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. TiPS 11 25 PMID: 2155495
If you know of a relevant reference for DNQX disodium salt, please let us know.
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Keywords: Water-soluble salt Glutamate Kainate Receptors iGluR Ionotropic AMPA non-NMDA AMPA Receptors
5 Citations for DNQX disodium salt
Citations are publications that use Tocris products. Selected citations for DNQX disodium salt include:
Pan et al (2016) Postnatal development of the electrophysiological properties of somatostatin interneurons in the anterior cingulate cortex of mice. J Neurosci 6 28137 PMID: 27319800
Dilger et al (2015) Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement. J Neurosci 35 3652 PMID: 25716863
Tseng et al (2015) Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors. Sci Rep 112 1214 PMID: 25552561
Lindstrom et al (2010) Retinal input to efferent target amacrine cells in the avian retina. Proc Natl Acad Sci U S A 27 103 PMID: 20650017
Linnemann et al (2006) Transient change in GABA(A) receptor subunit mRNA expression in Lurcher cerebellar nuclei during Purkinje cell degeneration. Vis Neurosci 7 59 PMID: 16872511
Do you know of a great paper that uses DNQX disodium salt from Tocris? If so please let us know.
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