DNQX disodium salt

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Description: Selective non-NMDA iGluR antagonist; water-soluble salt of DNQX (Cat. No. 0189)
Chemical Name: 6,7-Dinitroquinoxaline-2,3-dione disodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations (8)
Reviews (2)
Literature (5)

Biological Activity for DNQX disodium salt

DNQX disodium salt is a more water-soluble form of DNQX (Cat. No. 0189). DNQX is a selective non-NMDA glutamate receptor antagonist. (IC50 = 0.1 μM and 0.5 μM for kainate and AMPA receptors, respectively). DNQX is a neuroleptic agent that shows pro-oxidative properties. DNQX selectively depolarizes rat thalamic reticular nucleus neurons.

Technical Data for DNQX disodium salt

M. Wt 296.1
Formula C8H2N4O6Na2
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1312992-24-7
PubChem ID 45073428
InChI Key GPSBSOYURFUVKJ-UHFFFAOYSA-L
Smiles [Na+].[Na+].[O-]C1=C([O-])N=C2C=C(C(=CC2=N1)[N+]([O-])=O)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DNQX disodium salt

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 31.4 100

Preparing Stock Solutions for DNQX disodium salt

The following data is based on the product molecular weight 296.1. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.38 mL 16.89 mL 33.77 mL
5 mM 0.68 mL 3.38 mL 6.75 mL
10 mM 0.34 mL 1.69 mL 3.38 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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Product Datasheets for DNQX disodium salt

Certificate of Analysis / Product Datasheet
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References for DNQX disodium salt

References are publications that support the biological activity of the product.

Honore et al (1988) Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science 241 701 PMID: 2899909

Watkins et al (1990) Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. TiPS 11 25 PMID: 2155495

Šarlauskas et al (2013) Redox properties and prooxidant cytotoxicity of a neuroleptic agent 6,7-dinitrodihydroquinoxaline-2,3-dione (DNQX) Acta Biochim.Pol. 60 227 PMID: 23757451

Lee et al (2010) Selective excitatory actions of DNQX and CNQX in rat thalamic neurons. J.Neurophysiol. 103 1728 PMID: 20107128


If you know of a relevant reference for DNQX disodium salt, please let us know.

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Keywords: DNQX disodium salt, DNQX disodium salt supplier, Water-soluble, salt, Glutamate, Kainate, Receptors, iGluR, Ionotropic, AMPA, non-NMDA, neuroleptic, antagonists, 2312, Tocris Bioscience

8 Citations for DNQX disodium salt

Citations are publications that use Tocris products. Selected citations for DNQX disodium salt include:

Pan et al (2016) Postnatal development of the electrophysiological properties of somatostatin interneurons in the anterior cingulate cortex of mice. J Neurosci 6 28137 PMID: 27319800

Tseng et al (2015) Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors. Sci Rep 112 1214 PMID: 25552561

Abrahao et al (2017) Ethanol-Sensitive Pacemaker Neurons in the Mouse External Globus Pallidus. Neuropsychopharmacology 42 1070 PMID: 27827370

Dilger et al (2015) Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement. J Neurosci 35 3652 PMID: 25716863


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Reviews for DNQX disodium salt

Average Rating: 5 (Based on 2 Reviews.)

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Works as expected..
By Anonymous on 06/01/2020
Assay Type: Ex Vivo
Species: Mouse
Cell Line/Tissue: Paraventricular nucleus of hypothalamus

DNQX (20 micromolar) blocked spontaneous excitatory postsynaptic currents in an ex-vivo slice preparation.

PMID: 32133707
review image

Highly recommend.
By Anonymous on 05/14/2019
Assay Type: In Vivo
Species: Mouse

We delivered this drug intracranially in combination with AP5 to block glutamatergic transmission in the mouse VTA. Product was highly soluble and worked well and as described, producing a robust decrease in place preference behavior.

PMID: 27378337
review image

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