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Submit ReviewDNQX disodium salt
Description: Selective non-NMDA iGluR antagonist; water-soluble salt of DNQX (Cat. No. 0189)
Chemical Name: 6,7-Dinitroquinoxaline-2,3-dione disodium salt
Purity: ≥98% (HPLC)
Biological Activity for DNQX disodium salt
DNQX disodium salt is a more water-soluble form of DNQX (Cat. No. 0189). DNQX is a selective non-NMDA glutamate receptor antagonist. (IC50 = 0.1 μM and 0.5 μM for kainate and AMPA receptors, respectively). DNQX is a neuroleptic agent that shows pro-oxidative properties. DNQX selectively depolarizes rat thalamic reticular nucleus neurons.
Technical Data for DNQX disodium salt
| M. Wt | 296.1 |
| Formula | C8H2N4O6Na2 |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1312992-24-7 |
| PubChem ID | 45073428 |
| InChI Key | GPSBSOYURFUVKJ-UHFFFAOYSA-L |
| Smiles | [Na+].[Na+].[O-]C1=C([O-])N=C2C=C(C(=CC2=N1)[N+]([O-])=O)[N+]([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for DNQX disodium salt
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 31.4 | 100 |
Preparing Stock Solutions for DNQX disodium salt
The following data is based on the product molecular weight 296.1. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.38 mL | 16.89 mL | 33.77 mL |
| 5 mM | 0.68 mL | 3.38 mL | 6.75 mL |
| 10 mM | 0.34 mL | 1.69 mL | 3.38 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
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Product Datasheets for DNQX disodium salt
References for DNQX disodium salt
References are publications that support the biological activity of the product.
Honore et al (1988) Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science 241 701 PMID: 2899909
Watkins et al (1990) Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. TiPS 11 25 PMID: 2155495
Šarlauskas et al (2013) Redox properties and prooxidant cytotoxicity of a neuroleptic agent 6,7-dinitrodihydroquinoxaline-2,3-dione (DNQX) Acta Biochim.Pol. 60 227 PMID: 23757451
Lee et al (2010) Selective excitatory actions of DNQX and CNQX in rat thalamic neurons. J.Neurophysiol. 103 1728 PMID: 20107128
If you know of a relevant reference for DNQX disodium salt, please let us know.
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Keywords: DNQX disodium salt, DNQX disodium salt supplier, Water-soluble, salt, Glutamate, Kainate, Receptors, iGluR, Ionotropic, AMPA, non-NMDA, neuroleptic, antagonists, 2312, Tocris Bioscience
8 Citations for DNQX disodium salt
Citations are publications that use Tocris products. Selected citations for DNQX disodium salt include:
Lindstrom et al (2010) Retinal input to efferent target amacrine cells in the avian retina. Proc Natl Acad Sci U S A 27 103 PMID: 20650017
Tseng et al (2015) Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors. Sci Rep 112 1214 PMID: 25552561
Pan et al (2016) Postnatal development of the electrophysiological properties of somatostatin interneurons in the anterior cingulate cortex of mice. J Neurosci 6 28137 PMID: 27319800
Abrahao et al (2017) Ethanol-Sensitive Pacemaker Neurons in the Mouse External Globus Pallidus. Neuropsychopharmacology 42 1070 PMID: 27827370
Dilger et al (2015) Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement. J Neurosci 35 3652 PMID: 25716863
Loo et al (2019) Single-cell transcriptomic analysis of mouse neocortical development. Nat Commun 10 134 PMID: 30635555
Li et al (2019) TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala. Elife 8 PMID: 31482844
Linnemann et al (2006) Transient change in GABA(A) receptor subunit mRNA expression in Lurcher cerebellar nuclei during Purkinje cell degeneration. Vis Neurosci 7 59 PMID: 16872511
Do you know of a great paper that uses DNQX disodium salt from Tocris? Please let us know.
Reviews for DNQX disodium salt
Average Rating: 5 (Based on 2 Reviews.)
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Works as expected..
By
Anonymous on 06/01/2020
Assay Type: Ex Vivo
Species: Mouse
Cell Line/Tissue: Paraventricular nucleus of hypothalamus
DNQX (20 micromolar) blocked spontaneous excitatory postsynaptic currents in an ex-vivo slice preparation.
Highly recommend.
By
Anonymous on 05/14/2019
Assay Type: In Vivo
Species: Mouse
We delivered this drug intracranially in combination with AP5 to block glutamatergic transmission in the mouse VTA. Product was highly soluble and worked well and as described, producing a robust decrease in place preference behavior.
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