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Cat.No. 5601 - DMXAA | C17H14O4 | CAS No. 117570-53-3
Description: mSTING agonist; induces antitumor immunological responses
Chemical Name: 5,6-Dimethyl-9-oxo-9H-xanthene-4-acetic acid
Purity: ≥99% (HPLC)

Biological Activity

mSTING agonist; selective for mouse STING over human STING. Induces IFN-β and cytokine production from bone marrow-derived dendritic cells. Causes tumor regression following intratumoral administration in mouse tumor models. Induces an adaptive immune response to reduce systemic tumor growth and provides immunological memory against autologous tumor re-challenge. Also antiviral.

Technical Data

M. Wt 282.29
Formula C17H14O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 117570-53-3
PubChem ID 123964
Smiles O=C1C2=CC=CC(CC(O)=O)=C2OC3=C1C=CC(C)=C3C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 5.65 20
ethanol 1.41 5mM with sonication

Preparing Stock Solutions

The following data is based on the product molecular weight 282.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.54 mL 17.71 mL 35.42 mL
5 mM 0.71 mL 3.54 mL 7.08 mL
10 mM 0.35 mL 1.77 mL 3.54 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

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References are publications that support the products' biological activity.

Shirey et al (2011) The anti-tumor agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), induces IFN-β-mediated antiviral activity in vitro and in vivo. J.Leukoc.Biol. 89 351 PMID: 21084628

Corrales et al (2015) Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity. Cell Rep. 11 1018 PMID: 25959818

Phillips (1999) Inhibition of DT-diaphorase (NAD(P)H:quinone oxidoreductase, EC by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA): implications for bioreductive drug development. Biochem.Pharmacol. 58 303 PMID: 10423172

If you know of a relevant reference for DMXAA, please let us know.

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Keywords: DMXAA, supplier, mouse, STING, antitumor, adaptive, immunity, tumors, immunology, microenvironment, antiviral, Antivirals, STING-Dependent, Signaling, STING-Dependent, Signaling, Tocris Bioscience

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