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Description: mSTING agonist; induces antitumor immunological responses
Chemical Name: 5,6-Dimethyl-9-oxo-9H-xanthene-4-acetic acid
Purity: ≥99% (HPLC)
Citations (2)

Biological Activity for DMXAA

DMXAA is a mSTING agonist; selective for mouse STING over human STING. Induces IFN-β and cytokine production from bone marrow-derived dendritic cells. Causes tumor regression following intratumoral administration in mouse tumor models. Induces an adaptive immune response to reduce systemic tumor growth and provides immunological memory against autologous tumor re-challenge. Also antiviral.

Compound Libraries for DMXAA

DMXAA is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for DMXAA

M. Wt 282.29
Formula C17H14O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 117570-53-3
PubChem ID 123964
Smiles O=C1C2=CC=CC(CC(O)=O)=C2OC3=C1C=CC(C)=C3C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DMXAA

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 5.65 20

Preparing Stock Solutions for DMXAA

The following data is based on the product molecular weight 282.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 17.71 mL 88.56 mL 177.12 mL
1 mM 3.54 mL 17.71 mL 35.42 mL
2 mM 1.77 mL 8.86 mL 17.71 mL
10 mM 0.35 mL 1.77 mL 3.54 mL

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Product Datasheets for DMXAA

Certificate of Analysis / Product Datasheet
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References for DMXAA

References are publications that support the biological activity of the product.

Shirey et al (2011) The anti-tumor agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), induces IFN-β-mediated antiviral activity in vitro and in vivo. J.Leukoc.Biol. 89 351 PMID: 21084628

Corrales et al (2015) Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity. Cell Rep. 11 1018 PMID: 25959818

Phillips (1999) Inhibition of DT-diaphorase (NAD(P)H:quinone oxidoreductase, EC by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA): implications for bioreductive drug development. Biochem.Pharmacol. 58 303 PMID: 10423172

If you know of a relevant reference for DMXAA, please let us know.

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Keywords: DMXAA, DMXAA supplier, mouse, STING, antitumor, adaptive, immunity, tumors, immunology, microenvironment, antiviral, STING-Dependent, Signaling, Non-selective, Antivirals, 5601, Tocris Bioscience

2 Citations for DMXAA

Citations are publications that use Tocris products. Selected citations for DMXAA include:

Umesh S et al (2020) Protocols for Experimental Sjögren's Syndrome. Curr Protoc Immunol 131 e114 PMID: 33252847

Bryon D et al (2021) STING Activated Tumor-Intrinsic Type I Interferon Signaling Promotes CXCR3 Dependent Antitumor Immunity in Pancreatic Cancer. Cell Mol Gastroenterol Hepatol 12 41-58 PMID: 33548597

Do you know of a great paper that uses DMXAA from Tocris? Please let us know.

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