mSTING agonist; selective for mouse STING over human STING. Induces IFN-β and cytokine production from bone marrow-derived dendritic cells. Causes tumor regression following intratumoral administration in mouse tumor models. Induces an adaptive immune response to reduce systemic tumor growth and provides immunological memory against autologous tumor re-challenge. Also antiviral.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 282.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||17.71 mL||88.56 mL||177.12 mL|
|1 mM||3.54 mL||17.71 mL||35.42 mL|
|2 mM||1.77 mL||8.86 mL||17.71 mL|
|10 mM||0.35 mL||1.77 mL||3.54 mL|
References are publications that support the biological activity of the product.
Shirey et al (2011) The anti-tumor agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), induces IFN-β-mediated antiviral activity in vitro and in vivo. J.Leukoc.Biol. 89 351 PMID: 21084628
Corrales et al (2015) Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity. Cell Rep. 11 1018 PMID: 25959818
Phillips (1999) Inhibition of DT-diaphorase (NAD(P)H:quinone oxidoreductase, EC 220.127.116.11) by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA): implications for bioreductive drug development. Biochem.Pharmacol. 58 303 PMID: 10423172
If you know of a relevant reference for DMXAA, please let us know.
View Related Products by Product Action
Keywords: DMXAA, DMXAA supplier, mouse, STING, antitumor, adaptive, immunity, tumors, immunology, microenvironment, antiviral, Antivirals, STING-Dependent, Signaling, 5601, Tocris Bioscience
Citations for DMXAA
Citations are publications that use Tocris products.
Currently there are no citations for DMXAA. Do you know of a great paper that uses DMXAA from Tocris? Please let us know.
Reviews for DMXAA
There are currently no reviews for this product. Be the first to review DMXAA and earn rewards!
Have you used DMXAA?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.