DMXAA

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Cat.No. 5601 - DMXAA | C17H14O4 | CAS No. 117570-53-3
Description: mSTING agonist; induces antitumor immunological responses
Chemical Name: 5,6-Dimethyl-9-oxo-9H-xanthene-4-acetic acid
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

mSTING agonist; selective for mouse STING over human STING. Induces IFN-β and cytokine production from bone marrow-derived dendritic cells. Causes tumor regression following intratumoral administration in mouse tumor models. Induces an adaptive immune response to reduce systemic tumor growth and provides immunological memory against autologous tumor re-challenge. Also antiviral.

Compound Libraries

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Technical Data

M. Wt 282.29
Formula C17H14O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 117570-53-3
PubChem ID 123964
InChI Key XGOYIMQSIKSOBS-UHFFFAOYSA-N
Smiles O=C1C2=CC=CC(CC(O)=O)=C2OC3=C1C=CC(C)=C3C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.65 20

Preparing Stock Solutions

The following data is based on the product molecular weight 282.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 17.71 mL 88.56 mL 177.12 mL
1 mM 3.54 mL 17.71 mL 35.42 mL
2 mM 1.77 mL 8.86 mL 17.71 mL
10 mM 0.35 mL 1.77 mL 3.54 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Keywords: DMXAA, DMXAA supplier, mouse, STING, antitumor, adaptive, immunity, tumors, immunology, microenvironment, antiviral, Antivirals, STING-Dependent, Signaling, 5601, Tocris Bioscience

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Literature in this Area

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Immunology

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