Discontinued Product

d[Leu4,Lys8]-VP (Cat. No. 3127) has been withdrawn from sale for commercial reasons.
Cat.No. 3127 - d[leu4,Lys8]-VP | Mpr-Tyr-Phe-Leu-Asn-Cys-Pro-Lys-Gly-NH2 | CAS No. 42061-33-6
Description: Selective V1B agonist
Citations (1)
Literature (3)

Biological Activity for d[Leu4,Lys8]-VP

d[Leu4,Lys8]-VP is a selective vasopressin V1B receptor agonist (Ki values are 0.16, 64, 100 and 3800 nM for V1B, oxytocin, V2 and V1A receptors respectively). Displays weak antidiuretic, vasopressor and in vitro oxytocic activities.

Technical Data for d[Leu4,Lys8]-VP

M. Wt 1026.2
Formula C47H67N11O11S2

(Modifications: X = Mpr, Gly-9 = C-terminal amide, Disulfide bridge between X-1 - Cys-6)

Storage Store at -20°C
CAS Number 42061-33-6
PubChem ID 44419030
Smiles CC(C)C[C@@H]1NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)CCSSC[C@H](NC(=O)[C@H](CC(N)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)NCC(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for d[Leu4,Lys8]-VP

Certificate of Analysis / Product Datasheet
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References for d[Leu4,Lys8]-VP

References are publications that support the biological activity of the product.

Pena et al (2007) Design and synthesis of the frist selective agonists for the rat vasopressin V1b receptor: based on modifications of deamino-[cys1]arginine vasopressin at positions 4 and 8. J.Med.Chem. 50 835 PMID: 17300166

Pena et al (2007) Pharmacological and physiological characterization of d[Leu4,Lys8]vasopressin, the first V1b-selective agonist for rat vasopressin/oxytocin receptors. Endocrinology 148 4136 PMID: 17495006

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Keywords: d[leu4,Lys8]-VP, d[leu4,Lys8]-VP supplier, Selective, V1b, agonists, V2, Receptors, Vasopressin, 3127, Tocris Bioscience

1 Citation for d[Leu4,Lys8]-VP

Citations are publications that use Tocris products. Selected citations for d[Leu4,Lys8]-VP include:

Leroy et al (2018) A circuit from hippocampal CA2 to lateral septum disinhibits social aggression. Nature 564 213 PMID: 30518859

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Literature in this Area

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