Selective vasopressin V1B receptor agonist (Ki values are 0.16, 64, 100 and 3800 nM for V1B, oxytocin, V2 and V1A receptors respectively). Displays weak antidiuretic, vasopressor and in vitro oxytocic activities.
(Modifications: X = Mpr, Gly-9 = C-terminal amide, Disulfide bridge between X-1 - Cys-6)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 2 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1026.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.97 mL||4.87 mL||9.74 mL|
|5 mM||0.19 mL||0.97 mL||1.95 mL|
|10 mM||0.1 mL||0.49 mL||0.97 mL|
|50 mM||0.02 mL||0.1 mL||0.19 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Pena et al (2007) Design and synthesis of the frist selective agonists for the rat vasopressin V1b receptor: based on modifications of deamino-[cys1]arginine vasopressin at positions 4 and 8. J.Med.Chem. 50 835 PMID: 17300166
Pena et al (2007) Pharmacological and physiological characterization of d[Leu4,Lys8]vasopressin, the first V1b-selective agonist for rat vasopressin/oxytocin receptors. Endocrinology 148 4136 PMID: 17495006
If you know of a relevant reference for d[Leu4,Lys8]-VP, please let us know.
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Keywords: Selective V1b agonists V2 Receptors Vasopressin Vasopressin Receptors
Citations for d[Leu4,Lys8]-VP
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