Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewHigh affinity and selective CB1 receptor antagonist (Ki = 7.8 nM). Exhibits 1000-fold selectivity for CB1 over CB2 receptors. Inhibits CP 55,940-induced hypotension and WIN 55,212-2-induced hypothermia in vivo. Orally active.
M. Wt | 487.4 |
Formula | C23H20Cl2N4O2S |
Storage | Store at +4°C |
Purity | ≥98% (HPLC) |
CAS Number | 362519-49-1 |
PubChem ID | 11179267 |
InChI Key | AXJQVVLKUYCICH-UHFFFAOYSA-N |
Smiles | ClC(C=C4)=CC=C4C1=NN(/C(NS(C3=CC=C(Cl)C=C3)(=O)=O)=N\C)CC1C2=CC=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 48.74 | 100 | |
ethanol | 4.87 | 10 with gentle warming |
The following data is based on the product molecular weight 487.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.05 mL | 10.26 mL | 20.52 mL |
5 mM | 0.41 mL | 2.05 mL | 4.1 mL |
10 mM | 0.21 mL | 1.03 mL | 2.05 mL |
50 mM | 0.04 mL | 0.21 mL | 0.41 mL |
References are publications that support the biological activity of the product.
Lange et al (2004) Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB1 cannabinoid receptor antagonists. J.Med.Chem. 47 627 PMID: 14736243
Lange et al (2005) Novel 3,4-diarylpyrazolines as potent cannabinoid CB1 receptor antagonists with lower lipophilicity. Bioorg.Med.Chem.Lett. 15 4794 PMID: 16140010
If you know of a relevant reference for (±)-SLV 319, please let us know.
Keywords: (±)-SLV 319, (±)-SLV 319 supplier, (±)-SLV319, SLV, 319, SLV319, potent, selective, CB1, antagonists, cannabinoids, receptors, Receptors, 4605, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for (±)-SLV 319. Do you know of a great paper that uses (±)-SLV 319 from Tocris? Please let us know.
There are currently no reviews for this product. Be the first to review (±)-SLV 319 and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.