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Biological Activity for (±)-Epibatidine
(±)-Epibatidine is a high affinity nicotinic agonist (Ki values are 0.02 and 233 nM for α4β2 and α7 nicotinic receptors respectively). Analgesic.
Sold under license from the NIH, US Patent 5,314,899
Technical Data for (±)-Epibatidine
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for (±)-Epibatidine
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for (±)-Epibatidine
The following data is based on the product molecular weight 208.69. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.79 mL||23.96 mL||47.92 mL|
|5 mM||0.96 mL||4.79 mL||9.58 mL|
|10 mM||0.48 mL||2.4 mL||4.79 mL|
|50 mM||0.1 mL||0.48 mL||0.96 mL|
References for (±)-Epibatidine
References are publications that support the biological activity of the product.
Badio and Daly (1994) Epibatidine, a potent analgesic and nicotinic agonist. Mol.Pharmacol. 45 563 PMID: 8183234
Gerzarich et al (1995) Comparative pharmacology of epibatidine; a potent agonist for neuronal nicotinic acetylcholine receptors. Mol.Pharmacol. 48 774 PMID: 7476906
Marks et al (1998) Differential agonist inhibition identifies multiple epibatidine binidng sites in mouse brain. J.Pharmacol.Exp.Ther. 285 377 PMID: 9536034
Sharples et al (2000) UB-165 implicates α4β2 nAChR in striatal DA release. J.Neurosci. 20 2783 PMID: 10751429
Spande et al (1992) Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity. J.Am.Chem.Soc. 114 3475
If you know of a relevant reference for (±)-Epibatidine, please let us know.
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Keywords: (±)-Epibatidine, (±)-Epibatidine supplier, potent, nicotinic, agonists, Acetylcholine, Nicotinic, Receptors, Non-Selective, nAChR, (Non-selective), 0684, Tocris Bioscience
3 Citations for (±)-Epibatidine
Citations are publications that use Tocris products. Selected citations for (±)-Epibatidine include:
Noviello et al (2021) Structure and gating mechanism of the α7 nicotinic acetylcholine receptor. Cell 184 2121 PMID: 33735609
Williams et al (2007) The effect of epibatidine on spontaneous and evoked neurotransmitter release in the mouse and guinea pig isolated vas deferens. Br J Pharmacol 150 906 PMID: 17325648
Beckel et al (2006) Expression of functional nicotinic acetylcholine receptors in rat urinary bladder epithelial cells. J Neurosci 290 F103 PMID: 16144967
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Literature in this Area
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.