High affinity nicotinic agonist (Ki values are 0.02 and 233 nM for α4β2 and α7 nicotinic receptors respectively). Analgesic.
Sold under license from the NIH, US Patent 5,314,899
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 208.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.79 mL||23.96 mL||47.92 mL|
|5 mM||0.96 mL||4.79 mL||9.58 mL|
|10 mM||0.48 mL||2.4 mL||4.79 mL|
|50 mM||0.1 mL||0.48 mL||0.96 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Badio and Daly (1994) Epibatidine, a potent analgesic and nicotinic agonist. Mol.Pharmacol. 45 563 PMID: 8183234
Gerzarich et al (1995) Comparative pharmacology of epibatidine; a potent agonist for neuronal nicotinic acetylcholine receptors. Mol.Pharmacol. 48 774 PMID: 7476906
Marks et al (1998) Differential agonist inhibition identifies multiple epibatidine binidng sites in mouse brain. J.Pharmacol.Exp.Ther. 285 377 PMID: 9536034
Sharples et al (2000) UB-165 implicates α4β2 nAChR in striatal dopamine release. J.Neurosci. 20 2783 PMID: 10751429
If you know of a relevant reference for (±)-Epibatidine, please let us know.
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Keywords: potent nicotinic agonists Acetylcholine Nicotinic Receptors Non-Selective nAChR Nicotinic Receptors (Non-selective)
1 Citation for (±)-Epibatidine
Citations are publications that use Tocris products. Selected citations for (±)-Epibatidine include:
Beckel et al (2006) Expression of functional nicotinic acetylcholine receptors in rat urinary bladder epithelial cells. J Neurosci 290 F103 PMID: 16144967
Do you know of a great paper that uses (±)-Epibatidine from Tocris? If so please let us know.
Literature in this Area
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.