Pricing Availability   Qty
Description: High affinity nAChR agonist
Chemical Name: (±)-exo-2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1.]heptane
Purity: ≥98% (HPLC)
Citations (3)
Literature (1)

Biological Activity for (±)-Epibatidine

(±)-Epibatidine is a high affinity nicotinic agonist (Ki values are 0.02 and 233 nM for α4β2 and α7 nicotinic receptors respectively). Analgesic.

Licensing Information

Sold under license from the NIH, US Patent 5,314,899

Technical Data for (±)-Epibatidine

M. Wt 208.69
Formula C11H13ClN2
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 148152-66-3
PubChem ID 1204
Smiles ClC(N=C3)=CC=C3C2C1CCC(C2)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (±)-Epibatidine

Solvent Max Conc. mg/mL Max Conc. mM
water 1.23 5
ethanol 24.55 100

Preparing Stock Solutions for (±)-Epibatidine

The following data is based on the product molecular weight 208.69. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.79 mL 23.96 mL 47.92 mL
5 mM 0.96 mL 4.79 mL 9.58 mL
10 mM 0.48 mL 2.4 mL 4.79 mL
50 mM 0.1 mL 0.48 mL 0.96 mL

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Product Datasheets for (±)-Epibatidine

Certificate of Analysis / Product Datasheet
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References for (±)-Epibatidine

References are publications that support the biological activity of the product.

Badio and Daly (1994) Epibatidine, a potent analgesic and nicotinic agonist. Mol.Pharmacol. 45 563 PMID: 8183234

Gerzarich et al (1995) Comparative pharmacology of epibatidine; a potent agonist for neuronal nicotinic acetylcholine receptors. Mol.Pharmacol. 48 774 PMID: 7476906

Marks et al (1998) Differential agonist inhibition identifies multiple epibatidine binidng sites in mouse brain. J.Pharmacol.Exp.Ther. 285 377 PMID: 9536034

Sharples et al (2000) UB-165 implicates α4β2 nAChR in striatal DA release. J.Neurosci. 20 2783 PMID: 10751429

Spande et al (1992) Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity. J.Am.Chem.Soc. 114 3475

If you know of a relevant reference for (±)-Epibatidine, please let us know.

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Keywords: (±)-Epibatidine, (±)-Epibatidine supplier, potent, nicotinic, agonists, Acetylcholine, Nicotinic, Receptors, Non-Selective, nAChR, (Non-selective), 0684, Tocris Bioscience

3 Citations for (±)-Epibatidine

Citations are publications that use Tocris products. Selected citations for (±)-Epibatidine include:

Noviello et al (2021) Structure and gating mechanism of the α7 nicotinic acetylcholine receptor. Cell 184 2121 PMID: 33735609

Beckel et al (2006) Expression of functional nicotinic acetylcholine receptors in rat urinary bladder epithelial cells. J Neurosci 290 F103 PMID: 16144967

Williams et al (2007) The effect of epibatidine on spontaneous and evoked neurotransmitter release in the mouse and guinea pig isolated vas deferens. Br J Pharmacol 150 906 PMID: 17325648

Do you know of a great paper that uses (±)-Epibatidine from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.