(±)-Bisoprolol hemifumarate

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Cat.No. 0914 - (±)-Bisoprolol hemifumarate | C18H31NO4.½C4H4O4 | CAS No. 104344-23-2
Description: β1 antagonist
Chemical Name: (±)-1-[4-[[2-(1-Methylethoxy)ethoxy)methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol hemifumarate
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

A selective β1-adrenergic antagonist. Has a Kd of 2-3 nM at the β1 receptor and a β1/β2 selectivity of approximately 100-fold.

Technical Data

M. Wt 383.48
Formula C18H31NO4.½C4H4O4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 104344-23-2
PubChem ID 5281064
InChI Key VMDFASMUILANOL-WXXKFALUSA-N
Smiles OC(=O)\C=C\C(O)=O.CC(C)NCC(O)COC1=CC=C(COCCOC(C)C)C=C1.CC(C)NCC(O)COC1=CC=C(COCCOC(C)C)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.35 100
ethanol 38.35 100
water 19.17 50

Preparing Stock Solutions

The following data is based on the product molecular weight 383.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.61 mL 13.04 mL 26.08 mL
5 mM 0.52 mL 2.61 mL 5.22 mL
10 mM 0.26 mL 1.3 mL 2.61 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Heible et al (1995) α-and β-Adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J.Med.Chem. 38 3415 PMID: 7658428

Kaumann and Lemoine (1985) Direct labelling of myocardial β1-adrenoceptors. Comparison of binding affinity of 3H-(-)-bisoprolol with its blocking potency. Naunyn Schmiedebergs Arch.Pharmacol. 331 27 PMID: 2866449

Klockow et al (1986) Studies on the receptor profile of bisoprolol. Arzneimittelforschung 36 197 PMID: 2870719


If you know of a relevant reference for (±)-Bisoprolol hemifumarate, please let us know.

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View all Adrenergic β1 Receptor Antagonists

Keywords: α1-adrenoceptor beta1-adrenoceptor β1-Adrenergic beta1-Adrenergic b1-adrenoceptor b1-adrenergic antagonists Receptors Adrenergic Beta-1 Receptors

2 Citations for (±)-Bisoprolol hemifumarate

Citations are publications that use Tocris products. Selected citations for (±)-Bisoprolol hemifumarate include:

Littmann et al (2015) Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands. PLoS One 355 183 PMID: 26306764

Baker et al (2011) Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses. FASEB J 25 4486 PMID: 21865315


Do you know of a great paper that uses (±)-Bisoprolol hemifumarate from Tocris? If so please let us know.

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