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A selective β1-adrenergic antagonist. Has a Kd of 2-3 nM at the β1 receptor and a β1/β2 selectivity of approximately 100-fold.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 383.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.22 mL||26.08 mL||52.15 mL|
|2.5 mM||1.04 mL||5.22 mL||10.43 mL|
|5 mM||0.52 mL||2.61 mL||5.22 mL|
|25 mM||0.1 mL||0.52 mL||1.04 mL|
References are publications that support the biological activity of the product.
Heible et al (1995) α-and β-Adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J.Med.Chem. 38 3415 PMID: 7658428
Kaumann and Lemoine (1985) Direct labelling of myocardial β1-adrenoceptors. Comparison of binding affinity of 3H-(-)-bisoprolol with its blocking potency. Naunyn Schmiedebergs Arch.Pharmacol. 331 27 PMID: 2866449
Klockow et al (1986) Studies on the receptor profile of bisop. Arzneimittelforschung 36 197 PMID: 2870719
If you know of a relevant reference for (±)-Bisoprolol hemifumarate, please let us know.
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Keywords: (±)-Bisoprolol hemifumarate, (±)-Bisoprolol hemifumarate supplier, α1-adrenoceptor, beta1-adrenoceptor, β1-Adrenergic, beta1-Adrenergic, b1-adrenoceptor, b1-adrenergic, antagonists, Receptors, Adrenergic, Beta-1, 0914, Tocris Bioscience
3 Citations for (±)-Bisoprolol hemifumarate
Citations are publications that use Tocris products. Selected citations for (±)-Bisoprolol hemifumarate include:
Baker et al (2011) Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses. FASEB J 25 4486 PMID: 21865315
Kam et al (2005) Increased PKA activity and its influence on isoprenaline-stimulated L-type Ca2+ channels in the heart from ovariectomized rats. Br J Pharmacol 144 972 PMID: 15685204
Littmann et al (2015) Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands. PLoS One 355 183 PMID: 26306764
Do you know of a great paper that uses (±)-Bisoprolol hemifumarate from Tocris? Please let us know.
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Literature in this Area
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.