Disitertide

Pricing Availability   Qty
Description: TGF-β1 inhibitor
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature (6)
Pathways (1)

Biological Activity for Disitertide

Disitertide is a transforming growth factor-beta 1 (TGF-β1) inhibitor. In vitro, it inactivates TGF-β1/Smads signaling which reduces cell migration and invasion without affecting cell proliferation in colorectal carcinoma cell lines (Lovo and SW480 cells).

Technical Data for Disitertide

M. Wt 1580.83
Formula C68H109N17O22S2
Sequence TSLDASIIWAMMQN
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 272105-42-7
PubChem ID 9833838
InChI Key IUYPEUHIWDMJLM-SWHDLQTQSA-N
Smiles O=C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](C)C(N[C@@H](CCSC)C(N[C@@H](CCSC)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(N)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Disitertide

Solubility Soluble to 1 mg/ml in 0.01M PBS (pH 7.4)

References for Disitertide

References are publications that support the biological activity of the product.

Wu et al (2021) LINC00941 promotes CRC metastasis through preventing SMAD4 protein degradation and activating the TGF-β/SMAD2/3 signaling pathway. Cell Death Differ. 28 219 PMID: 32737443

Yao et al (2019) Activation of Slit2/Robo1 signaling promotes tumor metastasis in colorectal carcinoma through activation of the TGF-β/Smads pathway. Cells 8 635 PMID: 31242633

Feng et al (2020) Degradation of intracellular TGF-beta 1 by PROTACs efficiently reverses M2 macrophage induced malignant pathological events. Chem.Commun. 56 2881 PMID: 32037404

Qi et al (2021) PROTAC: An effective targeted protein degradation strategy for cancer therapy. Front.Pharmacol. 12 692574 PMID: 34025443


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Keywords: Disitertide, Disitertide supplier, TGF-βRI, TGF-β, TGF-betaRI, TGFbRI, TGFbR1, Kinases, Transforming, Growth, Factors, Beta, Receptors, TGF-beta, RSTK, Receptor, Serine/Threonine, RSTKs, 7717, Tocris Bioscience

Citations for Disitertide

Citations are publications that use Tocris products.

Currently there are no citations for Disitertide. Do you know of a great paper that uses Disitertide from Tocris? Please let us know.

Reviews for Disitertide

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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Pathways for Disitertide

TGF-β Signaling Pathway

TGF-β Signaling Pathway

The TGF-β signaling pathway is involved in the regulation of growth and proliferation of cells along with migration, differentiation and apoptosis.