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Biological Activity for Disitertide
Disitertide is a transforming growth factor-beta 1 (TGF-β1) inhibitor. In vitro, it inactivates TGF-β1/Smads signaling which reduces cell migration and invasion without affecting cell proliferation in colorectal carcinoma cell lines (Lovo and SW480 cells).
Technical Data for Disitertide
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Disitertide
|Solubility||Soluble to 1 mg/ml in 0.01M PBS (pH 7.4)|
References for Disitertide
References are publications that support the biological activity of the product.
Wu et al (2021) LINC00941 promotes CRC metastasis through preventing SMAD4 protein degradation and activating the TGF-β/SMAD2/3 signaling pathway. Cell Death Differ. 28 219 PMID: 32737443
Yao et al (2019) Activation of Slit2/Robo1 signaling promotes tumor metastasis in colorectal carcinoma through activation of the TGF-β/Smads pathway. Cells 8 635 PMID: 31242633
Feng et al (2020) Degradation of intracellular TGF-beta 1 by PROTACs efficiently reverses M2 macrophage induced malignant pathological events. Chem.Commun. 56 2881 PMID: 32037404
Qi et al (2021) PROTAC: An effective targeted protein degradation strategy for cancer therapy. Front.Pharmacol. 12 692574 PMID: 34025443
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Keywords: Disitertide, Disitertide supplier, TGF-βRI, TGF-β, TGF-betaRI, TGFbRI, TGFbR1, Kinases, Transforming, Growth, Factors, Beta, Receptors, TGF-beta, RSTK, Receptor, Serine/Threonine, RSTKs, 7717, Tocris Bioscience
Citations for Disitertide
Citations are publications that use Tocris products.
Currently there are no citations for Disitertide. Do you know of a great paper that uses Disitertide from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.