Diphenhydramine hydrochloride

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Description: H1 antagonist
Alternative Names: DPH
Chemical Name: 2-Diphenylmethoxy-N,N-dimethylethanamine hydrochloride
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity for Diphenhydramine hydrochloride

Diphenhydramine hydrochloride is a H1 receptor antagonist. Antihistamine.

Technical Data for Diphenhydramine hydrochloride

M. Wt 291.82
Formula C17H21NO.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 147-24-0
PubChem ID 8980
Smiles CN(CCOC(C2=CC=CC=C2)C1=CC=CC=C1)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Diphenhydramine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 29.18 100

Preparing Stock Solutions for Diphenhydramine hydrochloride

The following data is based on the product molecular weight 291.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.43 mL 17.13 mL 34.27 mL
5 mM 0.69 mL 3.43 mL 6.85 mL
10 mM 0.34 mL 1.71 mL 3.43 mL
50 mM 0.07 mL 0.34 mL 0.69 mL

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Product Datasheets for Diphenhydramine hydrochloride

References for Diphenhydramine hydrochloride

References are publications that support the biological activity of the product.

Khalia et al (1999) Block of potassium currents in guinea pig ventricular myocytes and lengthening of cardiac repolarization in man by the histamine H1 receptor antagonist diphenhydramide. J.Pharmacol.Exp.Ther. 288 858 PMID: 9918600

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Citations for Diphenhydramine hydrochloride

Citations are publications that use Tocris products.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Histamine Receptors Scientific Review

Histamine Receptors Scientific Review

Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.