DiMNF

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Cat.No. 4628 - DiMNF | C21H16O4 | CAS No. 14756-24-2
Description: Selective aryl hydrocarbon receptor modulator (SAhRM)
Chemical Name: 2-(3,4-Dimethoxyphenyl)-4H-naphtho[1,2-b]pyran-4-one
Purity: ≥99% (HPLC)
Datasheet
Citations
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Literature

Biological Activity

Selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). Suppresses expression of CD55 and CD46 induced by IL-1β in an inflammatory tumor cell microenvironment; exhibits no effect on basal CD55 or CD46 expression.

Technical Data

M. Wt 332.35
Formula C21H16O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 14756-24-2
PubChem ID 276138
InChI Key QDZQDIUUJDAORK-UHFFFAOYSA-N
Smiles O=C2C=C(C4=CC(OC)=C(OC)C=C4)OC1=C3C(C=CC=C3)=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 1.66 5

Preparing Stock Solutions

The following data is based on the product molecular weight 332.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.04 mL 30.09 mL
5 mM 0.6 mL 3.01 mL 6.02 mL
10 mM 0.3 mL 1.5 mL 3.01 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Labrecque et al (2012) Distinct roles for aryl hydrocarbon receptor nuclear translocator and Ah receptor in estrogen-mediated signaling in human cancer cell lines. PLoS ONE 7 e29545 PMID: 22235307

Murray et al (2011) Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3',4'-dimethoxy-α-naphthoflavone. Mol.Pharmacol. 79 508 PMID: 21127131

Narayanan et al (2012) Selective aryl hydrocarbon receptor modulator-mediated repression of CD55 expression induced by cytokine exposure. J.Pharmacol.Exp.Ther. 342 345 PMID: 22553215


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