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Cat.No. 4628 - DiMNF | C21H16O4 | CAS No. 14756-24-2
Description: Selective aryl hydrocarbon receptor modulator (SAhRM)
Chemical Name: 2-(3,4-Dimethoxyphenyl)-4H-naphtho[1,2-b]pyran-4-one
Purity: ≥99% (HPLC)
Reviews (1)
Literature (1)

Biological Activity

Selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). Suppresses expression of CD55 and CD46 induced by IL-1β in an inflammatory tumor cell microenvironment; exhibits no effect on basal CD55 or CD46 expression.

Technical Data

M. Wt 332.35
Formula C21H16O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 14756-24-2
PubChem ID 276138
Smiles O=C2C=C(C4=CC(OC)=C(OC)C=C4)OC1=C3C(C=CC=C3)=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 1.66 5

Preparing Stock Solutions

The following data is based on the product molecular weight 332.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 60.18 mL 300.89 mL 601.78 mL
0.25 mM 12.04 mL 60.18 mL 120.36 mL
0.5 mM 6.02 mL 30.09 mL 60.18 mL
2.5 mM 1.2 mL 6.02 mL 12.04 mL

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References are publications that support the biological activity of the product.

Labrecque et al (2012) Distinct roles for aryl hydrocarbon receptor nuclear translocator and Ah receptor in estrogen-mediated signaling in human cancer cell lines. PLoS ONE 7 e29545 PMID: 22235307

Murray et al (2011) Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3',4'-dimethoxy-α-naphthoflavone. Mol.Pharmacol. 79 508 PMID: 21127131

Narayanan et al (2012) Selective aryl hydrocarbon receptor modulator-mediated repression of CD55 expression induced by cytokine exposure. J.Pharmacol.Exp.Ther. 342 345 PMID: 22553215

If you know of a relevant reference for DiMNF, please let us know.

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Good compound.
By Anonymous on 08/20/2018
Assay Type: In Vitro
Species: Human

Used this compound to test published results, had great success. Dissolved easily in DMSO

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