DiMNF

Pricing Availability Delivery Time Qty
Cat.No. 4628 - DiMNF | C21H16O4 | CAS No. 14756-24-2
Description: Selective aryl hydrocarbon receptor modulator (SAhRM)
Chemical Name: 2-(3,4-Dimethoxyphenyl)-4H-naphtho[1,2-b]pyran-4-one
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective aryl hydrocarbon receptor (AHR) modulator (SAhRM). Suppresses expression of CD55 and CD46 induced by IL-1β in an inflammatory tumor cell microenvironment; exhibits no effect on basal CD55 or CD46 expression.

Technical Data

M. Wt 332.35
Formula C21H16O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 14756-24-2
PubChem ID 276138
InChI Key QDZQDIUUJDAORK-UHFFFAOYSA-N
Smiles O=C2C=C(C4=CC(OC)=C(OC)C=C4)OC1=C3C(C=CC=C3)=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 1.66 5

Preparing Stock Solutions

The following data is based on the product molecular weight 332.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.04 mL 30.09 mL
5 mM 0.6 mL 3.01 mL 6.02 mL
10 mM 0.3 mL 1.5 mL 3.01 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Labrecque et al (2012) Distinct roles for aryl hydrocarbon receptor nuclear translocator and Ah receptor in estrogen-mediated signaling in human cancer cell lines. PLoS ONE 7 e29545 PMID: 22235307

Murray et al (2011) Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3',4'-dimethoxy-α-naphthoflavone. Mol.Pharmacol. 79 508 PMID: 21127131

Narayanan et al (2012) Selective aryl hydrocarbon receptor modulator-mediated repression of CD55 expression induced by cytokine exposure. J.Pharmacol.Exp.Ther. 342 345 PMID: 22553215


If you know of a relevant reference for DiMNF, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Aryl Hydrocarbon Receptor Modulators

Keywords: DiMNF aryl hydrocarbon receptors AhRs modulators SAhRMs anti-inflammatories anti-inflammatory Aryl Hydrocarbon Receptors

Citations for DiMNF

Citations are publications that use Tocris products.

Currently there are no citations for DiMNF. Do you know of a great paper that uses DiMNF from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors

Pathways for DiMNF

Protocols

TODO: Add Protocols