Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewDiminazene aceturate
Description: ASIC blocker; antihyperalgesic
Chemical Name: 4,4'-(1-Triazene-1,3-diyl)bis[benzenecarboximidamide] bis(N-acetylglycinate)
Purity: ≥98% (HPLC)
Biological Activity for Diminazene aceturate
Diminazene aceturate is an ASIC blocker (IC50 values are 202, ~320, ~320 and 864 nM for ASIC1b, ASIC1a, ASIC3 and ASIC2a, respectively). Exhibits no activity in ENaC channels expressed in oocytes. Accelerates desensitization of ASIC currents in hippocampal neurons. Inhibits mesotrypsin (Ki = 3.6±0.3 μM). Displays in vitro and in vivo anti-inflammatory effects in mice. Antihyperalgesic.
Technical Data for Diminazene aceturate
| M. Wt | 515.52 |
| Formula | C14H15N7.2C4H7NO3 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 908-54-3 |
| PubChem ID | 5284544 |
| InChI Key | OKQSSSVVBOUMNZ-UHFFFAOYSA-N |
| Smiles | CC(NCC(O)=O)=O.CC(NCC(O)=O)=O.NC(C1=CC=C(C=C1)N/N=N/C2=CC=C(C(N)=N)C=C2)=N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Diminazene aceturate
References for Diminazene aceturate
References are publications that support the biological activity of the product.
Lee et al (2018) Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain. Br.J.Pharmacol. 175 2204 PMID: 29134638
Kayode et al (2017) Small molecule inhibitors of mesotrypsin from a structure-based docking screen. PLoS One 12 e0176694 PMID: 28463992
Chen et al (2010) Diarylamidines: high potency inhibitors of acid-sensing ion channels. Neuropharmacology 58 1045 PMID: 20114056
Krauson et al (2018) Molecular basis of inhibition of acid sensing ion channel 1A by diminazene. PLoS One 13 e0196894 PMID: 29782492
Goru et al (2017) Diminazene aceturate prevents nephropathy by increasing glomerular ACE2 and AT2 receptor expression in a rat model of type1 diabetes. Br.J.Pharmacol. 174 3118 PMID: 28688122
View Related Products by Target
View Related Products by Product Action
Keywords: Diminazene aceturate, Diminazene aceturate supplier, acid-sensing, acid, ion, channels, ASIC, blockers, analgesic, pain, thermal, mechanical, chemical, inflammatory, in, vivo, mesotrypsin, blocks, DIZE, 6705, Tocris Bioscience
Citations for Diminazene aceturate
Citations are publications that use Tocris products.
Currently there are no citations for Diminazene aceturate.
Reviews for Diminazene aceturate
There are currently no reviews for this product. Be the first to review Diminazene aceturate and earn rewards!
Have you used Diminazene aceturate?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image