Dihydrosphingosine

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Cat.No. 0749 - Dihydrosphingosine | C18H39NO2 | CAS No. 3102-56-5
Description: Protein kinase C inhibitor
Alternative Names: Sphinganine
Chemical Name: DL-erythro-1,3-Dihydroxy-2-aminooctadecane
Datasheet
Citations
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Literature

Biological Activity

Protein kinase C inhibitor.

Technical Data

M. Wt 301.51
Formula C18H39NO2
Storage Desiccate at -20°C
CAS Number 3102-56-5
PubChem ID 5746414
InChI Key OTKJDMGTUTTYMP-QZTJIDSGSA-N
Smiles OC[C@](N)([H])[C@H](O)CCCCCCCCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 301.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.32 mL 16.58 mL 33.17 mL
5 mM 0.66 mL 3.32 mL 6.63 mL
10 mM 0.33 mL 1.66 mL 3.32 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Yung et al (1993) Differential regulation of protein kinase C isoenzymes during sphinganine potentiation of retinoic acid-induced granulocytic differentiation in human leukemia HL-60 cells. Biochem.Biophys.Res.Commun. 196 1390 PMID: 8250895

Yung et al (1994) Sphinganine potentiation of dimethyl sulfoxide-induced granulocyte differentiation, increase of alkaline phosphatase activity and decrease of protein kinase C activity in a human leukemia cell line (HL-60). Biochem.Biophys.Res.Commun. 199 888 PMID: 8135836


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