Dianicline

Pricing Availability Delivery Time Qty
Cat.No. 5557 - Dianicline | C13H16N2O.2HCl | CAS No. 292634-27-6
Description: Selective α4β2 nAChR partial agonist
Chemical Name: (5aS,8S,10aR)-5a,6,9,10-Tetrahydro-7H,11H-8,10a-methanopyrido[2',3':5,6]pyrano[2,3-d]azepine
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective α4β2 nAChR partial agonist (IC50 = 105 nM). Exhibits >20-fold selectivity for α4β2 over other nAChR subtypes. Increases dopamine turnover in rat nucleus accumbens in vivo. Orally bioavailable.

Technical Data

M. Wt 289.2
Formula C13H16N2O.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 292634-27-6
PubChem ID 121513869
InChI Key WYIKBRGLNDJDEU-CQSOCPNPSA-N
Smiles [H][C@]12[C@](CN3CC2)(CC3)CC4=NC=CC=C4O1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.78 20
water 28.92 100

Preparing Stock Solutions

The following data is based on the product molecular weight 289.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.46 mL 17.29 mL 34.58 mL
5 mM 0.69 mL 3.46 mL 6.92 mL
10 mM 0.35 mL 1.73 mL 3.46 mL
50 mM 0.07 mL 0.35 mL 0.69 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Rollema et al (2010) Pre-clinical properties of the α4β2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence. Br.J.Pharmacol. 160 334 PMID: 0331614


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Citations for Dianicline

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Pathways for Dianicline

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