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Discontinued ProductDianicline (Cat. No. 5557) has been withdrawn from sale for commercial reasons.
Biological Activity for Dianicline
Selective α4β2 nAChR partial agonist (IC50 = 105 nM). Exhibits >20-fold selectivity for α4β2 over other nAChR subtypes. Increases dopamine turnover in rat nucleus accumbens in vivo. Orally bioavailable.
Technical Data for Dianicline
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for Dianicline
References are publications that support the biological activity of the product.
Rollema et al (2010) Pre-clinical properties of the α4β2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence. Br.J.Pharmacol. 160 334 PMID: 20331614
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Keywords: Dianicline, Dianicline supplier, nicotinic, acetylcholine, receptors, nAChR, partial, agonists, agonism, selective, α, β, alpha4beta2, orally, bioavailable, Nicotinic, (a4b2), Receptors, 5557, Tocris Bioscience
Citations for Dianicline
Citations are publications that use Tocris products.
Currently there are no citations for Dianicline.
Reviews for Dianicline
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Literature in this Area
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