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Selective α4β2 nAChR partial agonist (IC50 = 105 nM). Exhibits >20-fold selectivity for α4β2 over other nAChR subtypes. Increases dopamine turnover in rat nucleus accumbens in vivo. Orally bioavailable.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 289.2. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.46 mL||17.29 mL||34.58 mL|
|5 mM||0.69 mL||3.46 mL||6.92 mL|
|10 mM||0.35 mL||1.73 mL||3.46 mL|
|50 mM||0.07 mL||0.35 mL||0.69 mL|
References are publications that support the biological activity of the product.
Rollema et al (2010) Pre-clinical properties of the α4β2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence. Br.J.Pharmacol. 160 334 PMID: 20331614
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Keywords: Dianicline, Dianicline supplier, nicotinic, acetylcholine, receptors, nAChR, partial, agonists, agonism, selective, α, β, alpha4beta2, orally, bioavailable, Nicotinic, (a4b2), Receptors, 5557, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.