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Cat.No. 5557 - Dianicline | C13H16N2O.2HCl | CAS No. 292634-27-6
Description: Selective α4β2 nAChR partial agonist
Chemical Name: (5aS,8S,10aR)-5a,6,9,10-Tetrahydro-7H,11H-8,10a-methanopyrido[2',3':5,6]pyrano[2,3-d]azepine
Purity: ≥98% (HPLC)
Literature (5)

Biological Activity

Selective α4β2 nAChR partial agonist (IC50 = 105 nM). Exhibits >20-fold selectivity for α4β2 over other nAChR subtypes. Increases dopamine turnover in rat nucleus accumbens in vivo. Orally bioavailable.

Technical Data

M. Wt 289.2
Formula C13H16N2O.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 292634-27-6
PubChem ID 121513869
Smiles [H][C@]12[C@](CN3CC2)(CC3)CC4=NC=CC=C4O1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 28.92 100
DMSO 5.78 20

Preparing Stock Solutions

The following data is based on the product molecular weight 289.2. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.46 mL 17.29 mL 34.58 mL
5 mM 0.69 mL 3.46 mL 6.92 mL
10 mM 0.35 mL 1.73 mL 3.46 mL
50 mM 0.07 mL 0.35 mL 0.69 mL

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References are publications that support the biological activity of the product.

Rollema et al (2010) Pre-clinical properties of the α4β2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence. Br.J.Pharmacol. 160 334 PMID: 20331614

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Keywords: Dianicline, Dianicline supplier, nicotinic, acetylcholine, receptors, nAChR, partial, agonists, agonism, selective, α, β, alpha4beta2, orally, bioavailable, Nicotinic, (a4b2), Receptors, 5557, Tocris Bioscience

Citations for Dianicline

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Literature in this Area

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