Discontinued Product

Dianicline (Cat. No. 5557) has been withdrawn from sale for commercial reasons.
Description: Selective α4β2 nAChR partial agonist
Chemical Name: (5aS,8S,10aR)-5a,6,9,10-Tetrahydro-7H,11H-8,10a-methanopyrido[2',3':5,6]pyrano[2,3-d]azepine
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for Dianicline

Selective α4β2 nAChR partial agonist (IC50 = 105 nM). Exhibits >20-fold selectivity for α4β2 over other nAChR subtypes. Increases dopamine turnover in rat nucleus accumbens in vivo. Orally bioavailable.

Technical Data for Dianicline

M. Wt 289.2
Formula C13H16N2O.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 292634-27-6
PubChem ID 121513869
Smiles [H][C@]12[C@](CN3CC2)(CC3)CC4=NC=CC=C4O1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Dianicline

References are publications that support the biological activity of the product.

Rollema et al (2010) Pre-clinical properties of the α4β2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence. Br.J.Pharmacol. 160 334 PMID: 20331614

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Keywords: Dianicline, Dianicline supplier, nicotinic, acetylcholine, receptors, nAChR, partial, agonists, agonism, selective, α, β, alpha4beta2, orally, bioavailable, Nicotinic, (a4b2), Receptors, 5557, Tocris Bioscience

Citations for Dianicline

Citations are publications that use Tocris products.

Currently there are no citations for Dianicline.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.