Home / Pharmacology / Nuclear Receptors / PPARs / Non-selective PPAR / Non-selective PPAR Inverse Agonists / DG 172 dihydrochloride

DG 172 dihydrochloride

Cat. No. 5566 COA / Product Datasheet SDS
Pricing Availability Delivery Time Qty
Cat.No. 5566 - DG 172 dihydrochloride | C20H20BrN3.2HCl | CAS No. 1361504-77-9
Description: Potent PPARβ/δ inverse agonist; promotes BMC differentiation
Chemical Name: (αZ)-2-Bromo-α-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]benzeneacetonitrile dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent PPARβ/δ inverse agonist (IC50 = 26.9 nM). Inhibits Angptl4 gene expression in mouse myoblasts (IC50 = 9.5 nM) in vitro. Also augments GM-CSF/IL-4-induced differentiation of mature dendritic cells from bone marrow cells in culture. Orally available.

Compound Libraries

DG 172 dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 455.22
Formula C20H20BrN3.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1361504-77-9
PubChem ID 57342888
InChI Key SABUORLIDVBCPI-WTLOABTRSA-N
Smiles BrC(C=CC=C1)=C1/C(C#N)=C/C2=CC=C(N3CCN(C)CC3)C=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.52 100
water 45.52 100

Preparing Stock Solutions

The following data is based on the product molecular weight 455.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.2 mL 10.98 mL 21.97 mL
5 mM 0.44 mL 2.2 mL 4.39 mL
10 mM 0.22 mL 1.1 mL 2.2 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Safety Datasheet

References

References are publications that support the products' biological activity.

Lieber et al (2015) The inverse agonist DG172 triggers a PPARβ/δ-independent myeloid lineage shift and promotes GM-CSF/IL-4-induced dendritic cell differentiation. Mol.Pharmacol. 87 162 PMID: 25398837

Lieber et al (2012) (Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): an orally bioavailable PPARβ/δ-selective ligand with inverse agonistic properties. J.Med.Chem. 55 2858 PMID: 22369181

If you know of a relevant reference for DG 172 dihydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Non-selective PPAR Inverse Agonists

Keywords: DG 172 dihydrochloride, supplier, DG172, dihydrochloride, potent, PPARbeta/delta, peroxisome, proliferator, activated, receptor, inverse, agonist, dendritic, cell, differentiation, orally, available, PPARb/d, β/δ, Non-selective, PPAR, Neural, Stem, Cells, Non-selective, PPAR, Tocris Bioscience

Citations for DG 172 dihydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for DG 172 dihydrochloride. Do you know of a great paper that uses DG 172 dihydrochloride from Tocris? If so please let us know.

Reviews for DG 172 dihydrochloride

There are currently no reviews for this product. Be the first to review DG 172 dihydrochloride and earn rewards!

Have you used DG 172 dihydrochloride?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors