DG 172 dihydrochloride

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Cat.No. 5566 - DG 172 dihydrochloride | C20H20BrN3.2HCl | CAS No. 1361504-77-9
Description: Potent PPARβ/δ inverse agonist; promotes BMC differentiation
Chemical Name: (αZ)-2-Bromo-α-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]benzeneacetonitrile dihydrochloride
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for DG 172 dihydrochloride

DG 172 dihydrochloride is a potent PPARβ/δ inverse agonist (IC50 = 26.9 nM). Inhibits Angptl4 gene expression in mouse myoblasts (IC50 = 9.5 nM) in vitro. Also augments GM-CSF/IL-4-induced differentiation of mature dendritic cells from bone marrow cells in culture. Orally available.

Technical Data for DG 172 dihydrochloride

M. Wt 455.22
Formula C20H20BrN3.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1361504-77-9
PubChem ID 57342888
Smiles BrC(C=CC=C1)=C1/C(C#N)=C/C2=CC=C(N3CCN(C)CC3)C=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DG 172 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 45.52 100
DMSO 45.52 100

Preparing Stock Solutions for DG 172 dihydrochloride

The following data is based on the product molecular weight 455.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.2 mL 10.98 mL 21.97 mL
5 mM 0.44 mL 2.2 mL 4.39 mL
10 mM 0.22 mL 1.1 mL 2.2 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets for DG 172 dihydrochloride

References for DG 172 dihydrochloride

References are publications that support the biological activity of the product.

Lieber et al (2015) The inverse agonist DG172 triggers a PPARβ/δ-independent myeloid lineage shift and promotes GM-CSF/IL-4-induced dendritic cell differentiation. Mol.Pharmacol. 87 162 PMID: 25398837

Lieber et al (2012) (Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): an orally bioavailable PPARβ/δ-selective ligand with inverse agonistic properties. J.Med.Chem. 55 2858 PMID: 22369181

If you know of a relevant reference for DG 172 dihydrochloride, please let us know.

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Citations for DG 172 dihydrochloride

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