Dexfenfluramine hydrochloride

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Cat.No. 2695 - Dexfenfluramine hydrochloride | C12H16F3N.HCl | CAS No. 3239-45-0
Description: 5-HT reuptake inhibitor; also stimulates 5-HT release
Alternative Names: (+)-Fenfluramine
Chemical Name: (S)-N-Ethyl-α-methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride
Datasheet
Citations (4)
Reviews
Literature

Biological Activity

Indirectly agonizes serotonin receptors via inhibition of 5-HT re-uptake and stimulation of 5-HT release. Anorectic agent; decreases growth hormone, insulin, leptin, fat mass, lean mass and increases ghrelin in diet-switched diet-induced obese mice.

Technical Data

M. Wt 267.72
Formula C12H16F3N.HCl
Storage Desiccate at RT
CAS Number 3239-45-0
PubChem ID 66264
InChI Key ZXKXJHAOUFHNAS-FVGYRXGTSA-N
Smiles C[C@H](NCC)CC1=CC=CC(C(F)(F)F)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 26.77 100
DMSO 26.77 100

Preparing Stock Solutions

The following data is based on the product molecular weight 267.72. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.74 mL 18.68 mL 37.35 mL
5 mM 0.75 mL 3.74 mL 7.47 mL
10 mM 0.37 mL 1.87 mL 3.74 mL
50 mM 0.07 mL 0.37 mL 0.75 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Caccia et al (1997) Neuropharmacological effects of low and high doses of repeated oral dexfenfluramine in rats: a comparison with fluox. Pharmacol.Biochem.Behav. 57 851 PMID: 9259015

Higgins et al (2001) Influence of the 5-HT2C receptor antagonist SB242,084 on behaviour produced by the 5-HT2 agonist Ro60-0175 and the indirect 5-HT agonist dexfenfluramine. Br.J.Pharmacol. 133 459 PMID: 11399662

Bush et al (2006) Chronic treatment with either dexfenfluramine or sibutr. in diet-switched diet-induced obese mice. Endocrine 29 375 PMID: 16785615


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Keywords: Dexfenfluramine hydrochloride, Dexfenfluramine hydrochloride supplier, 5-HT, reuptake, inhibitors, inhibits, stimulates, release, Serotonin, 5-Hydroxytryptamine, Receptors, Transporters, SERT, Monoamine, Neurotransmitter, (+)-Fenfluramine, 5-HT-Related, 5-HT3, 2695, Tocris Bioscience

4 Citations for Dexfenfluramine hydrochloride

Citations are publications that use Tocris products. Selected citations for Dexfenfluramine hydrochloride include:

Banas et al (2011) Deconstructing antiobesity compound action: requirement of serotonin 5-HT2B receptors for dexfenfluramine anorectic effects. Neuropsychopharmacology 36 423 PMID: 20927048

Kiyasova et al (2011) A genetically defined morphologically and functionally unique subset of 5-HT neurons in the mouse raphe nuclei. J Neurosci 31 2756 PMID: 21414898

Lyons et al (2016) Serotonin and Antidepressant SSRIs Inhibit Rat Neuroendocrine DA Neurons: Parallel Actions in the Lactotrophic Axis The journal of Neuroscience 36 7392 PMID: 27413150

Rodríguez-Muñoz et al (2018) Fenfluramine diminishes NMDA receptor-mediated seizures via its mixed activity at serotonin 5HT2A and type 1 sigma receptors. Oncotarget 9 23373 PMID: 29805740


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Literature in this Area

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5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.