Dexfenfluramine hydrochloride

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Cat.No. 2695 - Dexfenfluramine hydrochloride | C12H16F3N.HCl | CAS No. 3239-45-0
Description: 5-HT re-uptake inhibitor. Also stimulates 5-HT release
Alternative Names: (+)-Fenfluramine
Chemical Name: (S)-N-Ethyl-α-methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Indirectly agonizes serotonin receptors via inhibition of 5-HT re-uptake and stimulation of 5-HT release. Anorectic agent; decreases growth hormone, insulin, leptin, fat mass, lean mass and increases ghrelin in diet-switched diet-induced obese mice.

Technical Data

M. Wt 267.72
Formula C12H16F3N.HCl
Storage Desiccate at RT
CAS Number 3239-45-0
PubChem ID 66264
InChI Key ZXKXJHAOUFHNAS-FVGYRXGTSA-N
Smiles C[C@H](NCC)CC1=CC=CC(C(F)(F)F)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.77 100
water 26.77 100

Preparing Stock Solutions

The following data is based on the product molecular weight 267.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.74 mL 18.68 mL 37.35 mL
5 mM 0.75 mL 3.74 mL 7.47 mL
10 mM 0.37 mL 1.87 mL 3.74 mL
50 mM 0.07 mL 0.37 mL 0.75 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Caccia et al (1997) Neuropharmacological effects of low and high doses of repeated oral dexfenfluramine in rats: a comparison with fluoxetine. Pharmacol.Biochem.Behav. 57 851 PMID: 9259015

Higgins et al (2001) Influence of the 5-HT2C receptor antagonist SB242,084 on behaviour produced by the 5-HT2 agonist Ro60-0175 and the indirect 5-HT agonist dexfenfluramine. Br.J.Pharmacol. 133 459 PMID: 11399662

Bush et al (2006) Chronic treatment with either dexfenfluramine or sibutramine in diet-switched diet-induced obese mice. Endocrine 29 375 PMID: 16785615


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Keywords: Dexfenfluramine hydrochloride, supplier, 5-HT, reuptake, inhibitors, inhibits, stimulates, release, Serotonin, 5-Hydroxytryptamine, Receptors, Transporters, SERT, Monoamine, Neurotransmitter, (+)-Fenfluramine, 5-HT, Transporters, 5-HT-Related, 5-HT3, Receptors, 5-HT, Transporters, Tocris Bioscience

2 Citations for Dexfenfluramine hydrochloride

Citations are publications that use Tocris products. Selected citations for Dexfenfluramine hydrochloride include:

Lyons et al (2016) Serotonin and Antidepressant SSRIs Inhibit Rat Neuroendocrine Dopamine Neurons: Parallel Actions in the Lactotrophic Axis The journal of Neuroscience 36 7392 PMID: 27413150

Kiyasova et al (2011) A genetically defined morphologically and functionally unique subset of 5-HT neurons in the mouse raphe nuclei. J Neurosci 31 2756 PMID: 21414898


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Literature in this Area

Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
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  • Huntington's disease
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.