Tricothecene mycotoxin and potent protein synthesis inhibitor. Exhibits cytotoxic activity in vivo via the ribotoxic stress response. Induces p38-mediated gene expression and apoptosis in leukocytes; activity results in systemic expression of interleukin-6 (IL-6) and other proinflammatory cytokines. Also induces migration of NF-κB into the nucleus.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 296.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.3 mM||11.25 mL||56.25 mL||112.49 mL|
|1.5 mM||2.25 mL||11.25 mL||22.5 mL|
|3 mM||1.12 mL||5.62 mL||11.25 mL|
|15 mM||0.22 mL||1.12 mL||2.25 mL|
References are publications that support the biological activity of the product.
Bae and Pestka (2008) Deoxynivalenol induces p38 interaction with the ribosome in monocytes and macrophages. Toxicol.Sci. 105 59 PMID: 18502741
Shi et al (2009) Role of GRP78/BiP degradation and ER stress in deoxynivalenol-induced interleukin-6 upregulation in the macrophage. Toxicol.Sci. 109 247 PMID: 19336499
Krishnaswamy et al (2010) Lutein protects HT-29 cells against deoxynivalenol-induced oxidative stress and apoptosis: prevention of NF-κB nuclear localization and down regulation of NF-κB and cyclo-oxygenase-2 expression. Free Radic.Biol.Med. 49 50 PMID: 20347963
If you know of a relevant reference for Deoxynivalenol, please let us know.
View Related Products by Target
Keywords: Deoxynivalenol, Deoxynivalenol supplier, DON, vomitoxin, cytotoxic, mycotoxin, protein, synthesis, inhibitors, inhibits, 3a,7a,15-Trihydroxy-12,13-epoxytrichothec-9-en-8-one, Vomitoxin, Miscellaneous, Compounds, 3976, Tocris Bioscience
Citations for Deoxynivalenol
Citations are publications that use Tocris products.
Currently there are no citations for Deoxynivalenol. Do you know of a great paper that uses Deoxynivalenol from Tocris? Please let us know.
Reviews for Deoxynivalenol
There are currently no reviews for this product. Be the first to review Deoxynivalenol and earn rewards!
Have you used Deoxynivalenol?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide (Spring/Summer 2018)
Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Cell Metabolism
- Fluorescent Imaging
- Signal Transduction
- Stem Cells