Deoxynivalenol

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Cat.No. 3976 - Deoxynivalenol | C15H20O6 | CAS No. 51481-10-8
Description: Mycotoxin; potent protein synthesis inhibitor
Alternative Names: DON, Vomitoxin
Chemical Name: 3α,7α,15-Trihydroxy-12,13-epoxytrichothec-9-en-8-one
Datasheet
Citations
Reviews
Literature

Biological Activity

Tricothecene mycotoxin and potent protein synthesis inhibitor. Exhibits cytotoxic activity in vivo via the ribotoxic stress response. Induces p38-mediated gene expression and apoptosis in leukocytes; activity results in systemic expression of interleukin-6 (IL-6) and other proinflammatory cytokines. Also induces migration of NF-κB into the nucleus.

Technical Data

M. Wt 296.32
Formula C15H20O6
Storage Store at +4°C
CAS Number 51481-10-8
PubChem ID 40024
InChI Key LINOMUASTDIRTM-QGRHZQQGSA-N
Smiles CC1=C[C@]2([H])[C@]([C@@](C)(C[C@H]4O)[C@]3(CO3)[C@@]([H])4O2)(CO)[C@H](O)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 8.89 30

Preparing Stock Solutions

The following data is based on the product molecular weight 296.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.37 mL 16.87 mL 33.75 mL
5 mM 0.67 mL 3.37 mL 6.75 mL
10 mM 0.34 mL 1.69 mL 3.37 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Bae and Pestka (2008) Deoxynivalenol induces p38 interaction with the ribosome in monocytes and macrophages. Toxicol.Sci. 105 59 PMID: 18502741

Shi et al (2009) Role of GRP78/BiP degradation and ER stress in deoxynivalenol-induced interleukin-6 upregulation in the macrophage. Toxicol.Sci. 109 247 PMID: 19336499

Krishnaswamy et al (2010) Lutein protects HT-29 cells against deoxynivalenol-induced oxidative stress and apoptosis: prevention of NF-κB nuclear localization and down regulation of NF-κB and cyclo-oxygenase-2 expression. Free Radic.Biol.Med. 49 50 PMID: 20347963


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Keywords: Deoxynivalenol, Deoxynivalenol supplier, DON, vomitoxin, cytotoxic, mycotoxin, protein, synthesis, inhibitors, inhibits, 3a,7a,15-Trihydroxy-12,13-epoxytrichothec-9-en-8-one, Vomitoxin, Miscellaneous, Compounds, 3976, Tocris Bioscience

Citations for Deoxynivalenol

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Literature in this Area

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