Deltorphin I
Biological Activity
Potent δ-opioid receptor agonist (IC50 = 0.5 nM in human granulocytes). Exhibits a high rate of blood-brain barrier penetrance.
Technical Data
| M. Wt | 768.87 |
| Formula | C37H52N8O10 |
| Sequence |
YAFDVVG (Modifications: Ala-2 = D-Ala, Gly-7 = C-terminal amide) |
| Storage | Store at -20°C |
| CAS Number | 122752-15-2 |
| PubChem ID | 10055958 |
| InChI Key | CJAORFIPPWIGPG-QXYJMILXSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)NCC(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 0.40 mg/ml in 50% acetonitrile / water |
Preparing Stock Solutions
The following data is based on the product molecular weight 768.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.3 mL | 6.5 mL | 13.01 mL |
| 5 mM | 0.26 mL | 1.3 mL | 2.6 mL |
| 10 mM | 0.13 mL | 0.65 mL | 1.3 mL |
| 50 mM | 0.03 mL | 0.13 mL | 0.26 mL |
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References
References are publications that support the products' biological activity.
If you know of a relevant reference for Deltorphin I, please let us know.
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Keywords: DeltorphinI delta d δ opioids agonists brain penetrant bbb Delta Opioid Receptors
1 Citation for Deltorphin I
Citations are publications that use Tocris products. Selected citations for Deltorphin I include:
Otis et al (2011) Spinal activation of delta opioid receptors alleviates cancer-related bone pain. Neuroscience 183 221 PMID: 21458544
Do you know of a great paper that uses Deltorphin I from Tocris? If so please let us know.
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