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Submit ReviewPotent δ-opioid receptor agonist (IC50 = 0.5 nM in human granulocytes). Exhibits a high rate of blood-brain barrier penetrance.
M. Wt | 768.87 |
Formula | C37H52N8O10 |
Sequence |
YAFDVVG (Modifications: Ala-2 = D-Ala, Gly-7 = C-terminal amide) |
Storage | Store at -20°C |
CAS Number | 122752-15-2 |
PubChem ID | 10055958 |
InChI Key | CJAORFIPPWIGPG-QXYJMILXSA-N |
Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)NCC(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility | Soluble to 1 mg/ml in 20% formic acid |
References are publications that support the biological activity of the product.
Stefano et al (1992) [D-Ala2]Deltorphin I binding and pharmacological evidence for a special subtype of δ opioid receptor on human and invertebrate immune cells. Proc.Natl.Acad.Sci.USA 89 9316 PMID: 1329092
Erspamer et al (1989) Deltorphins: a family of naturally occurring peptides with high affinity and selectivity for δ opioid binding sites. Proc.Natl.Acad.Sci.USA 86 5188 PMID: 2544892
Fiori et al (1997) Deltorphin transport across the blood-brain barrier. Proc.Natl.Acad.Sci.USA 94 9469 PMID: 9256506
If you know of a relevant reference for Deltorphin I, please let us know.
Keywords: Deltorphin I, Deltorphin I supplier, DeltorphinI, delta, d, δ, opioids, agonists, brain, penetrant, bbb, Delta, Opioid, Receptors, 4591, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for Deltorphin I include:
Otis et al (2011) Spinal activation of delta opioid receptors alleviates cancer-related bone pain. Neuroscience 183 221 PMID: 21458544
Do you know of a great paper that uses Deltorphin I from Tocris? Please let us know.
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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