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Potent δ-opioid receptor agonist (IC50 = 0.5 nM in human granulocytes). Exhibits a high rate of blood-brain barrier penetrance.
(Modifications: Ala-2 = D-Ala, Gly-7 = C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in 20% formic acid|
References are publications that support the biological activity of the product.
Stefano et al (1992) [D-Ala2]Deltorphin I binding and pharmacological evidence for a special subtype of δ opioid receptor on human and invertebrate immune cells. Proc.Natl.Acad.Sci.USA 89 9316 PMID: 1329092
Erspamer et al (1989) Deltorphins: a family of naturally occurring peptides with high affinity and selectivity for δ opioid binding sites. Proc.Natl.Acad.Sci.USA 86 5188 PMID: 2544892
Fiori et al (1997) Deltorphin transport across the blood-brain barrier. Proc.Natl.Acad.Sci.USA 94 9469 PMID: 9256506
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Keywords: Deltorphin I, Deltorphin I supplier, DeltorphinI, delta, d, δ, opioids, agonists, brain, penetrant, bbb, Delta, Opioid, Receptors, 4591, Tocris Bioscience
1 Citation for Deltorphin I
Citations are publications that use Tocris products. Selected citations for Deltorphin I include:
Otis et al (2011) Spinal activation of delta opioid receptors alleviates cancer-related bone pain. Neuroscience 183 221 PMID: 21458544
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.