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Submit ReviewDeltorphin I
Description: Potent δ agonist
Biological Activity
Potent δ-opioid receptor agonist (IC50 = 0.5 nM in human granulocytes). Exhibits a high rate of blood-brain barrier penetrance.
Technical Data
| M. Wt | 768.87 |
| Formula | C37H52N8O10 |
| Sequence |
YAFDVVG (Modifications: Ala-2 = D-Ala, Gly-7 = C-terminal amide) |
| Storage | Store at -20°C |
| CAS Number | 122752-15-2 |
| PubChem ID | 10055958 |
| InChI Key | CJAORFIPPWIGPG-QXYJMILXSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)NCC(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solubility | Soluble to 1 mg/ml in 20% formic acid |
Product Datasheets
References
References are publications that support the biological activity of the product.
Stefano et al (1992) [D-Ala2]Deltorphin I binding and pharmacological evidence for a special subtype of δ opioid receptor on human and invertebrate immune cells. Proc.Natl.Acad.Sci.USA 89 9316 PMID: 1329092
Erspamer et al (1989) Deltorphins: a family of naturally occurring peptides with high affinity and selectivity for δ opioid binding sites. Proc.Natl.Acad.Sci.USA 86 5188 PMID: 2544892
Fiori et al (1997) Deltorphin transport across the blood-brain barrier. Proc.Natl.Acad.Sci.USA 94 9469 PMID: 9256506
If you know of a relevant reference for Deltorphin I, please let us know.
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1 Citation for Deltorphin I
Citations are publications that use Tocris products. Selected citations for Deltorphin I include:
Otis et al (2011) Spinal activation of delta opioid receptors alleviates cancer-related bone pain. Neuroscience 183 221 PMID: 21458544
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