Deltorphin I

Pricing Availability   Qty
Cat.No. 4591 - Deltorphin I | Tyr-D-Ala-Phe-Asp-Val-Val-Gly-NH2 | CAS No. 122752-15-2
Description: Potent δ agonist
Datasheet
Citations (1)
Reviews
Literature (5)

Biological Activity

Potent δ-opioid receptor agonist (IC50 = 0.5 nM in human granulocytes). Exhibits a high rate of blood-brain barrier penetrance.

Technical Data

M. Wt 768.87
Formula C37H52N8O10
Sequence YAFDVVG

(Modifications: Ala-2 = D-Ala, Gly-7 = C-terminal amide)

Storage Store at -20°C
CAS Number 122752-15-2
PubChem ID 10055958
InChI Key CJAORFIPPWIGPG-QXYJMILXSA-N
Smiles [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)NCC(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in 20% formic acid

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Stefano et al (1992) [D-Ala2]Deltorphin I binding and pharmacological evidence for a special subtype of δ opioid receptor on human and invertebrate immune cells. Proc.Natl.Acad.Sci.USA 89 9316 PMID: 1329092

Erspamer et al (1989) Deltorphins: a family of naturally occurring peptides with high affinity and selectivity for δ opioid binding sites. Proc.Natl.Acad.Sci.USA 86 5188 PMID: 2544892

Fiori et al (1997) Deltorphin transport across the blood-brain barrier. Proc.Natl.Acad.Sci.USA 94 9469 PMID: 9256506


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1 Citation for Deltorphin I

Citations are publications that use Tocris products. Selected citations for Deltorphin I include:

Otis et al (2011) Spinal activation of delta opioid receptors alleviates cancer-related bone pain. Neuroscience 183 221 PMID: 21458544


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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