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Non-nucleoside reverse transcriptase inhibitor (NNRTI). Selectively inhibits HIV-1 reverse transcriptase (RNA-dependent DNA polymerase) over other cellular polymerases (IC50 values are 0.26, 440 and >550 μM for HIV-1 reverse transcriptase, DNA polymerase α and DNA polymerase δ). Prevents HIV-1 spread in vivo and blocks viral replication in peripheral blood lymphocytes. Orally active.
Sold for research purposes under agreement from Viiv.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 552.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.75 mM||2.41 mL||12.06 mL||24.13 mL|
|3.75 mM||0.48 mL||2.41 mL||4.83 mL|
|7.5 mM||0.24 mL||1.21 mL||2.41 mL|
|37.5 mM||0.05 mL||0.24 mL||0.48 mL|
References are publications that support the biological activity of the product.
Dueweke et al (1993) U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication. Antimicrob.Agents Chemother. 37 1127 PMID: 7685995
Pagano and Chong (1995) In vitro inhibition of human immunodeficiency virus type 1 by a combination of delavi. (U-90152) with protease inhibitor U-75875 or IF.-alpha. J.Infect.Dis. 171 61 PMID: 7528253
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.