Delavirdine mesylate

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Cat.No. 4149 - Delavirdine mesylate | C22H28N6O3S.CH3SO3H | CAS No. 147221-93-0
Description: Non-nucleoside reverse transcriptase inhibitor
Alternative Names: U 90152
Chemical Name: 1-[3-[(1-Methylethyl)amino]-2-pyridinyl]-4-[[5-[(methylsulfonyl)amino]-1H-indol-2-yl]carbonyl]-piperazine monomethanesulfonate
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity

Non-nucleoside reverse transcriptase inhibitor (NNRTI). Selectively inhibits HIV-1 reverse transcriptase (RNA-dependent DNA polymerase) over other cellular polymerases (IC50 values are 0.26, 440 and >550 μM for HIV-1 reverse transcriptase, DNA polymerase α and DNA polymerase δ). Prevents HIV-1 spread in vivo and blocks viral replication in peripheral blood lymphocytes. Orally active.

Licensing Information

Sold for research purposes under agreement from Viiv.

Compound Libraries

Delavirdine mesylate is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 552.67
Formula C22H28N6O3S.CH3SO3H
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 147221-93-0
PubChem ID 441386
InChI Key MEPNHSOMXMALDZ-UHFFFAOYSA-N
Smiles O=C(N3CCN(C4=NC=CC=C4NC(C)C)CC3)C2=CC1=CC(NS(=O)(C)=O)=CC=C1N2.CS(O)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.45 75

Preparing Stock Solutions

The following data is based on the product molecular weight 552.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 2.41 mL 12.06 mL 24.13 mL
3.75 mM 0.48 mL 2.41 mL 4.83 mL
7.5 mM 0.24 mL 1.21 mL 2.41 mL
37.5 mM 0.05 mL 0.24 mL 0.48 mL

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References

References are publications that support the biological activity of the product.

Dueweke et al (1993) U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication. Antimicrob.Agents Chemother. 37 1127 PMID: 7685995

Pagano and Chong (1995) In vitro inhibition of human immunodeficiency virus type 1 by a combination of delavi. (U-90152) with protease inhibitor U-75875 or IF.-alpha. J.Infect.Dis. 171 61 PMID: 7528253


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Keywords: Delavirdine mesylate, Delavirdine mesylate supplier, reverse, transcriptase, inhibitors, inhibits, polymerases, RNA/DNA, antivirals, antiretrovirals, HIV, non-nucleoside, NNRTI, HIV-1, U90152, U, 90152, Polymerase, Antivirals, 4149, Tocris Bioscience

Citations for Delavirdine mesylate

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