Discontinued Product

Deguelin (Cat. No. 1770) has been withdrawn from sale for commercial reasons.
Description: Anticancer and antiviral agent; chemopreventive and pro-apoptotic
Chemical Name: (7aS,13aS)-13,13a-Dihydro-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one
Purity: ≥97% (HPLC)
Citations (2)
Literature (1)
Pathways (1)

Biological Activity for Deguelin

Anticancer and antiviral agent; chemopreventive and pro-apoptotic. Inhibits phorbol ester-induced ornithine decarboxylase and NADH:ubiquinone oxidoreductase activities (IC50 values are 11 and 6.9 nM respectively). Inhibits PI 3-kinase and reduces pAkt levels in pre-malignant and malignant human bronchial epithelial cells. Active in vivo.

Technical Data for Deguelin

M. Wt 394.42
Formula C23H22O6
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 522-17-8
PubChem ID 107935
Smiles O=C(C(C=CC5=C4C=CC(C)(C)O5)=C4O3)[C@@]([C@@]3([H])CO2)([H])C1=C2C=C(OC)C(OC)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Deguelin

Certificate of Analysis / Product Datasheet
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References for Deguelin

References are publications that support the biological activity of the product.

Chun et al (2003) Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells. J.Natl.Cancer Inst. 95 291 PMID: 12591985

Fang and Casida (1998) Anticancer action of cube insecticide: correlation for rotenoid constituents between inhibition of NADH:ubiquinone oxidoreductase and induced ornithine decarboxylase activities. Proc.Natl.Acad.Sci.U.S.A. 95 3380 PMID: 9520374

Takatsuki et al (1969) Antiviral and antitumor antibiotics. XX. Effects of rotenone, deguelin, and related compounds on animal and plant viruses. Appl.Microbiol. 18 660 PMID: 4312925

Udeani et al (1997) Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid. Cancer Res. 57 3424 PMID: 9270008

Keywords: Deguelin, Deguelin supplier, Anticancer, antiviral, agent, chemopreventive, proapoptotic, Apoptosis, Inducer, Inducers, Non-selective, Antivirals, 1770, Tocris Bioscience

2 Citations for Deguelin

Citations are publications that use Tocris products. Selected citations for Deguelin include:

Hafeez et al (2016) BAD, a Proapoptotic Protein, Escapes ERK/RSK Phosphorylation in Deguelin and siRNA-Treated HeLa Cells. J Neurosci 11 e0145780 PMID: 26745145

Rebolleda et al (2016) Synergistic Activity of Deguelin and fludar. in Cells from Chronic Lymphocytic Leukemia Patients and in the New Zealand Black Murine Model. PLoS One 11 e0154159 PMID: 27101369

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Deguelin

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.