Cytosine analog that once incorporated into DNA acts as a suicide substrate for DNA methyltransferase. Inhibits DNA methyltransferase and results in DNA hypomethylation and activation of silent genes. Chemotherapeutic agent; suppresses growth of human tumor cell lines. Demethylates differentiation-related genes; reverses embryonic stem cell differentiation.
Decitabine is also offered as part of the Tocriscreen Plus, Tocriscreen Epigenetics Toolbox and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 228.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.38 mL||21.91 mL||43.82 mL|
|5 mM||0.88 mL||4.38 mL||8.76 mL|
|10 mM||0.44 mL||2.19 mL||4.38 mL|
|50 mM||0.09 mL||0.44 mL||0.88 mL|
References are publications that support the products' biological activity.
Bender et al (1998) Inhibition of DNA methylation by 5-aza-2'-deoxycytidine supresses the growth of human tumour cell lines. Cancer Res. 58 95 PMID: 9426064
Momparler (2005) Pharmacology of 5-aza-2'-deoxycytidine (decitabine). Semin.Hematol. 42 S9 PMID: 16015507
If you know of a relevant reference for Decitabine, please let us know.
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Keywords: Decitabine, supplier, DNA, methyltransferase, inhibitors, inhibits, Transferases, stem, cells, NSC127716, epigenetics, 5-Aza-2'-deoxycytidine, 2'-Deoxy-5-azacytidine, chemotherapeutics, 2'-Deoxy-5-azacytidine, 5-Aza-2'-deoxycytidine, NSC, 127716, DNA, Methyltransferases, DNA, Methyltransferases, Tocris Bioscience
4 Citations for Decitabine
Citations are publications that use Tocris products. Selected citations for Decitabine include:
Wang et al (2012) Down-regulation of HtrA1 activates the epithelial-mesenchymal transition and ATM DNA damage response pathways. PLoS One 7 e39446 PMID: 22761798
Trowbridge et al (2012) Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains. BMC Cancer 26 344 PMID: 22345515
Vendetti et al (2015) Evaluation of azacitidine and entinostat as sensitization agents to cytotoxic chemotherapy in preclinical models of non-small cell lung cancer. Genes Dev 6 56 PMID: 25474141
Gu et al (2014) Runx1 regulation of Pu.1 corepressor/coactivator exchange identifies specific molecular targets for leukemia differentiation therapy. J Biol Chem 289 14881 PMID: 24695740
Do you know of a great paper that uses Decitabine from Tocris? If so please let us know.
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Literature in this Area
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Epigenetics Research Bulletin
Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:
- DNA Methyltransferases
- Histone Deacetylases
- Histone Demethylases
- Histone Methyltransferases