DDR1-IN-1 dihydrochloride

Pricing Availability   Qty
Description: Selective DDR1 inhibitor
Chemical Name: N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide dihydrochloride
Purity: ≥98% (HPLC)
Citations (6)
Reviews (1)

Biological Activity for DDR1-IN-1 dihydrochloride

DDR1-IN-1 dihydrochloride is a selective discoidin domain receptor 1 (DDR1) tyrosine kinase inhibitor (IC50 values are 105 and 413 nM for DDR1 and DDR2 respectively). Inhibits integrin-induced DDR1 autophosphorylation in an osteosarcoma cell line.

External Portal Information for DDR1-IN-1 dihydrochloride

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of DDR1-IN-1 is reviewed on the chemical probes website.

Compound Libraries for DDR1-IN-1 dihydrochloride

DDR1-IN-1 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for DDR1-IN-1 dihydrochloride

M. Wt 625.51
Formula C30H31F3N4O3.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1780303-76-5
PubChem ID 90489006
Smiles CC1=C(OC4=CC(CC(N5)=O)=C5C=C4)C=C(NC(C2=CC=C(CN3CCN(CC)CC3)C(C(F)(F)F)=C2)=O)C=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DDR1-IN-1 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 62.55 100
DMSO 31.28 50

Preparing Stock Solutions for DDR1-IN-1 dihydrochloride

The following data is based on the product molecular weight 625.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.6 mL 7.99 mL 15.99 mL
5 mM 0.32 mL 1.6 mL 3.2 mL
10 mM 0.16 mL 0.8 mL 1.6 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

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Product Datasheets for DDR1-IN-1 dihydrochloride

Certificate of Analysis / Product Datasheet
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References for DDR1-IN-1 dihydrochloride

References are publications that support the biological activity of the product.

Kim et al (2013) Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor. ACS.Chem.Biol. 8 2145 PMID: 23899692

Canning et al (2014) Structural Mechanisms Determining Inhibition of the Collagen Receptor DDR1 by Selective and Multi-Targeted Type II Kinase Inhibitors. J.Mol.Biol. 426 2457 PMID: 24768818

If you know of a relevant reference for DDR1-IN-1 dihydrochloride, please let us know.

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Keywords: DDR1-IN-1 dihydrochloride, DDR1-IN-1 dihydrochloride supplier, selective, discoidin, domain, receptors, DDR1, DDR2, tyrosine, kinases, Other, RTKs, 5077, Tocris Bioscience

6 Citations for DDR1-IN-1 dihydrochloride

Citations are publications that use Tocris products. Selected citations for DDR1-IN-1 dihydrochloride include:

Romayor et al (2020) Silencing of sinusoidal DDR1 reduces murine liver metastasis by colon carcinoma. Sci Rep 10 18398 PMID: 33110221

Malaguarnera et al (2015) Novel cross talk between IGF-IR and DDR1 regulates IGF-IR trafficking, signaling and biological responses. BMC Complement Altern Med 6 16084 PMID: 25840417

Piyush B et al (2021) Breast tissue regeneration is driven by cell-matrix interactions coordinating multi-lineage stem cell differentiation through DDR1. Nat Commun 12 7116 PMID: 34893587

Vehlow et al (2019) Interaction of Discoidin Domain Receptor 1 with a 14-3-3-Beclin-1-Akt1 Complex Modulates Glioblastoma Therapy Sensitivity. Cell Rep 26 3672 PMID: 30917320

Do you know of a great paper that uses DDR1-IN-1 dihydrochloride from Tocris? Please let us know.

Reviews for DDR1-IN-1 dihydrochloride

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Collagen type 1 activated collagen receptor discoidin domain receptor.
By Anonymous on 02/21/2020
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: 3D Culture Matrix

10 μg/ml treat 24h and 48h

PMID: 29330408
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