DDR1-IN-1 dihydrochloride

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Cat.No. 5077 - DDR1-IN-1 dihydrochloride | C30H31F3N4O3.2HCl
Description: Selective DDR1 inhibitor
Chemical Name: N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Selective discoidin domain receptor 1 (DDR1) tyrosine kinase inhibitor (IC50 values are 105 and 413 nM for DDR1 and DDR2 respectively). Inhibits integrin-induced DDR1 autophosphorylation in an osteosarcoma cell line.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of DDR1-IN-1 is reviewed on the chemical probes website.

Compound Libraries

DDR1-IN-1 dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 625.51
Formula C30H31F3N4O3.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
PubChem ID 90489006
InChI Key PBUOJKYQZINPKD-UHFFFAOYSA-N
Smiles CC1=C(OC4=CC(CC(N5)=O)=C5C=C4)C=C(NC(C2=CC=C(CN3CCN(CC)CC3)C(C(F)(F)F)=C2)=O)C=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 62.55 100
DMSO 31.28 50

Preparing Stock Solutions

The following data is based on the product molecular weight 625.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.6 mL 7.99 mL 15.99 mL
5 mM 0.32 mL 1.6 mL 3.2 mL
10 mM 0.16 mL 0.8 mL 1.6 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Kim et al (2013) Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor. ACS.Chem.Biol. 8 2145 PMID: 23899692

Canning et al (2014) Structural Mechanisms Determining Inhibition of the Collagen Receptor DDR1 by Selective and Multi-Targeted Type II Kinase Inhibitors. J.Mol.Biol. 426 2457 PMID: 24768818


If you know of a relevant reference for DDR1-IN-1 dihydrochloride, please let us know.

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Keywords: DDR1-IN-1 dihydrochloride, supplier, selective, discoidin, domain, receptors, DDR1, DDR2, tyrosine, kinases, Other, RTKs, Other, RTKs, Tocris Bioscience

2 Citations for DDR1-IN-1 dihydrochloride

Citations are publications that use Tocris products. Selected citations for DDR1-IN-1 dihydrochloride include:

Mogami (2018) Collagen Type 1 accelerates healing of ruptured fetal membranes. Sci Rep 8 696 PMID: 29330408

Malaguarnera et al (2015) Novel cross talk between IGF-IR and DDR1 regulates IGF-IR trafficking, signaling and biological responses. BMC Complement Altern Med 6 16084 PMID: 25840417


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Literature in this Area

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