d[Cha4]-AVP

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Cat.No. 3126 - d[Cha4]-AVP | Mpr-Tyr-Phe-Cha-Asn-Cys-Pro-Arg-Gly-NH2 | CAS No. 500170-27-4
Description: Potent and selective human V1B agonist
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Potent and selective human vasopressin V1B receptor agonist (Ki values are 1.2, 151, 240 and 750 nM for V1B, V1A, Oxytocin and V2 receptors respectively). Stimulates ACTH and corticosterone secretion and exhibits negligible vasopressor activity in vivo.

Technical Data

M. Wt 1094.31
Formula C50H71N13O11S2
Sequence XYFXNCPRG

(Modifications: X-1 = Mpr, X-4 = Cha, Gly-9 = C-terminal amide, Disulfide bridge between X-1 - Cys-6)

Storage Store at -20°C
CAS Number 500170-27-4
PubChem ID 44419028
InChI Key ZKYCVZNKBXGNEK-ZTYVOHGWSA-N
Smiles NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](CC2=CC=C(O)C=C2)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](CC(N)=O)C(=O)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Derick et al (2002) [1-Deamino-4-cyclohexylalanine] arginine vasopressin: a potent and specific agonist for vasopressin V1b receptors. Endocrinology 143 4655 PMID: 12446593

Cheng et al (2004) Design of potent and selective agonists for the human vasopressin V1b receptor based on modifications of [deamino-cys1]arginine vasopressin at position 4. J.Med.Chem. 47 2375 PMID: 15084136

Pena et al (2007) Design and synthesis of the frist selective agonists for the rat vasopressin V1b receptor: based on modifications of deamino-[cys1]arginine vasopressin at positions 4 and 8. J.Med.Chem. 50 835 PMID: 17300166


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Keywords: d[Cha4]-AVP, d[Cha4]-AVP supplier, Potent, selective, human, V1b, agonists, V2, Receptors, Vasopressin, 3126, Tocris Bioscience

1 Citation for d[Cha4]-AVP

Citations are publications that use Tocris products. Selected citations for d[Cha4]-AVP include:

Perígolo-Vicente et al (2014) IL-6, A1 and A2aR: a crosstalk that modulates BDNF and induces neuroprotection. Biochem Biophys Res Commun 449 477 PMID: 24845382


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