d[Cha4]-AVP
![Cat.No. 3126 - d[Cha4]-AVP | Mpr-Tyr-Phe-Cha-Asn-Cys-Pro-Arg-Gly-NH2 | CAS No. 500170-27-4](http://resources.tocris.com/images/datasheets/structures/dcha4-avp_3126.png "Cat.No. 3126 - d[Cha4]-AVP | Mpr-Tyr-Phe-Cha-Asn-Cys-Pro-Arg-Gly-NH2 | CAS No. 500170-27-4")
Biological Activity
Potent and selective human vasopressin V1B receptor agonist (Ki values are 1.2, 151, 240 and 750 nM for V1B, V1A, Oxytocin and V2 receptors respectively). Stimulates ACTH and corticosterone secretion and exhibits negligible vasopressor activity in vivo.
Technical Data
| M. Wt | 1094.31 |
| Formula | C50H71N13O11S2 |
| Sequence |
XYFXNCPRG (Modifications: X-1 = Mpr, X-4 = Cha, Gly-9 = C-terminal amide, Disulfide bridge between X-1 - Cys-6) |
| Storage | Store at -20°C |
| CAS Number | 500170-27-4 |
| PubChem ID | 44419028 |
| InChI Key | ZKYCVZNKBXGNEK-ZTYVOHGWSA-N |
| Smiles | NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](CC2=CC=C(O)C=C2)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](CC(N)=O)C(=O)N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1094.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.91 mL | 4.57 mL | 9.14 mL |
| 5 mM | 0.18 mL | 0.91 mL | 1.83 mL |
| 10 mM | 0.09 mL | 0.46 mL | 0.91 mL |
| 50 mM | 0.02 mL | 0.09 mL | 0.18 mL |
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References
References are publications that support the products' biological activity.
Derick et al (2002) [1-Deamino-4-cyclohexylalanine] arginine vasopressin: a potent and specific agonist for vasopressin V1b receptors. Endocrinology 143 4655 PMID: 12446593
Cheng et al (2004) Design of potent and selective agonists for the human vasopressin V1b receptor based on modifications of [deamino-cys1]arginine vasopressin at position 4. J.Med.Chem. 47 2375 PMID: 15084136
Pena et al (2007) Design and synthesis of the frist selective agonists for the rat vasopressin V1b receptor: based on modifications of deamino-[cys1]arginine vasopressin at positions 4 and 8. J.Med.Chem. 50 835 PMID: 17300166
If you know of a relevant reference for d[Cha4]-AVP, please let us know.
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Keywords: Potent selective human V1b agonists V2 Receptors Vasopressin Vasopressin Receptors
1 Citation for d[Cha4]-AVP
Citations are publications that use Tocris products. Selected citations for d[Cha4]-AVP include:
Perígolo-Vicente et al (2014) IL-6, A1 and A2aR: a crosstalk that modulates BDNF and induces neuroprotection. Biochem Biophys Res Commun 449 477 PMID: 24845382
Do you know of a great paper that uses d[Cha4]-AVP from Tocris? If so please let us know.
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