Darapladib

Pricing Availability   Qty
Cat.No. 6755 - Darapladib | C36H38F4N4O2S | CAS No. 356057-34-6
Description: Potent lp-PLA2 inhibitor
Chemical Name: N-[2-(Diethylamino)ethyl]-2-[[(4-fluorophenyl)methyl]thio]-4,5,6,7-tetrahydro-4-oxo-N-[[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methyl]-1H-cyclopentapyrimidine-1-acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent lipoprotein-associated phospholipase A2 (lp-PLA2) inhibitor (IC50 = 5 nM in whole human plasma).

Technical Data

M. Wt 666.77
Formula C36H38F4N4O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 356057-34-6
PubChem ID 9939609
InChI Key WDPFJWLDPVQCAJ-UHFFFAOYSA-N
Smiles CCN(CCN(C(CN1C2=C(C(N=C1SCC3=CC=C(C=C3)F)=O)CCC2)=O)CC4=CC=C(C5=CC=C(C(F)(F)F)C=C5)C=C4)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 66.68 100
ethanol 66.68 100

Preparing Stock Solutions

The following data is based on the product molecular weight 666.77. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.5 mL 7.5 mL 15 mL
5 mM 0.3 mL 1.5 mL 3 mL
10 mM 0.15 mL 0.75 mL 1.5 mL
50 mM 0.03 mL 0.15 mL 0.3 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Blackie et al (2003) The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2. Bioorg.Med.Chem.Lett. 13 1067 PMID: 12643913


If you know of a relevant reference for Darapladib, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Phospholipase Inhibitors

Keywords: Darapladib, Darapladib supplier, SB480848, lipoprotein, associated, phospholipase, A2, inhibitors, inhibits, potent, lpPLA2, lp-PLA2, Phospholipases, 6755, Tocris Bioscience

Citations for Darapladib

Citations are publications that use Tocris products.

Currently there are no citations for Darapladib. Do you know of a great paper that uses Darapladib from Tocris? Please let us know.

Reviews for Darapladib

There are currently no reviews for this product. Be the first to review Darapladib and earn rewards!

Have you used Darapladib?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Asthma

Asthma Poster

Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.