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Potent lipoprotein-associated phospholipase A2 (lp-PLA2) inhibitor (IC50 = 5 nM in whole human plasma).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 666.77. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.5 mL||7.5 mL||15 mL|
|5 mM||0.3 mL||1.5 mL||3 mL|
|10 mM||0.15 mL||0.75 mL||1.5 mL|
|50 mM||0.03 mL||0.15 mL||0.3 mL|
References are publications that support the biological activity of the product.
Blackie et al (2003) The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2. Bioorg.Med.Chem.Lett. 13 1067 PMID: 12643913
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Keywords: Darapladib, Darapladib supplier, SB480848, lipoprotein, associated, phospholipase, A2, inhibitors, inhibits, potent, lpPLA2, lp-PLA2, Phospholipases, 6755, Tocris Bioscience
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