Daidzein

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Cat.No. 1417 - Daidzein | C15H10O4 | CAS No. 486-66-8
Description: Arrests cell cycle in G1 phase
Chemical Name: 7-Hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Analog of the phytoestrogen genistein (Cat. No. 1110). Blocks G1 phase cell cycle progression. Agonist at estrogen receptors.

Compound Libraries

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Technical Data

M. Wt 254.24
Formula C15H10O4
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 486-66-8
PubChem ID 5281708
InChI Key ZQSIJRDFPHDXIC-UHFFFAOYSA-N
Smiles OC1=CC=C(C=C1)C1=COC2=CC(O)=CC=C2C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 5.08 20mM with gentle warming
DMSO 25.42 100

Preparing Stock Solutions

The following data is based on the product molecular weight 254.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.93 mL 19.67 mL 39.33 mL
5 mM 0.79 mL 3.93 mL 7.87 mL
10 mM 0.39 mL 1.97 mL 3.93 mL
50 mM 0.08 mL 0.39 mL 0.79 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Casanova et al (1999) Development effects of dietary phytoestrogens in Sprague Dawley rats and interactions of genistein and daidzein with rat estrogen receptors α and β in vitro. Toxicol.Sci. 51 236 PMID: 10543025

Higashi and Ogawara (1994) Daidzein inhibits insulin- or insulin-like growth factor-1-mediated signaling in cell cycle progression of Swiss 3T3 cells. Biochim.Biophys.Acta 1221 29 PMID: 8130274

Jing et al (1993) Differentiation of promyelocytic leukemia cells HL-60 induced by daidzein in vitro and in vivo. Anticancer Res. 13 1049 PMID: 8352524


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Keywords: Arrests cell cycle G1 phase Estrogen receptor agonists induces arrest Cell Cycle inhibitors inhibits ER ERR Receptors Cell Cycle Inhibitors

Citations for Daidzein

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for Daidzein

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