Pricing Availability   Qty
Cat.No. 4272 - [D-Trp8]-gamma-MSH | Tyr-Val-Met-Gly-His-Phe-Arg-D-Trp-Asp-Arg-Phe-Gly | CAS No. 321351-81-9
Description: Selective MC3 receptor agonist
Literature (3)

Biological Activity

Selective melanocortin 3 (MC3) receptor agonist (IC50 values are 6.7, 340 and 600 nM for human MC3, MC5 and MC4 receptors respectively). Displays anti-inflammatory efficacy.

Technical Data

M. Wt 1570.79
Formula C74H99N21O16S

(Modifications: Trp-8 = D-Trp)

Storage Store at -20°C
CAS Number 321351-81-9
PubChem ID 16157270
Smiles [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Grieco et al (2000) D-amino acid scan of γ-melanocyte-stimulating hormone: importance of Trp8 on human MC3 receptor selectivity. J.Med.Chem. 43 4998 PMID: 11150170

Getting et al (2006) [D-Trp8]-γ-Melanocyte-stimulating-hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1R (recessive yellow e/e mouse). Mol.Pharmacol. 70 1850 PMID: 16959942

Patel et al (2010) Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis. FASEB J. 24 4835 PMID: 20702773

If you know of a relevant reference for [D-Trp8]-γ-MSH, please let us know.

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Keywords: [D-Trp8]-gamma-MSH, [D-Trp8]-gamma-MSH supplier, melanocortin, 3, receptors, MC3R, agonists, MC3, MC5, MC4, [D-Trp8]-gamma-MSH, [D-Trp8]-g-MSH, [D-Trp8]-γ-MSH, Melanocortin, Receptors, 4272, Tocris Bioscience

Citations for [D-Trp8]-γ-MSH

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