[D-Trp7,9,10]-Substance P

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Cat.No. 1884 - [D-Trp 7,9,10]-Substance P | Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-D-Trp-Met-NH2 | CAS No. 89430-38-6
Description: Inhibits M1 ACh receptor activation of Gq/11
Alternative Names: GPAnt-2 analog
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Substance P analog that inhibits activation of Gq/11 by M1 muscarinic ACh receptors. Does not inhibit Gi/o activation by M2 ACh receptors.

Technical Data

M. Wt 1588.89
Formula C79H105N21O13S
Sequence RPKPQQWFWWM

(Modifications: Trp-7, Trp-9, Trp-10 = D-Trp, Met-11 = C-terminal Amide)

Storage Store at -20°C
CAS Number 89430-38-6
PubChem ID 16143852
InChI Key ZDXXOQXJCDHSRG-GGDSLUOHSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Mukai et al (1992) G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding. J.Biol.Chem. 267 16237 PMID: 1379592


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View all G Protein (Heterotrimeric) Inhibitors

Keywords: [D-Trp 7,9,10]-Substance P, [D-Trp 7,9,10]-Substance P supplier, inhibitors, inhibits, M1, ACh, receptor, activation, Gq/11, G-Protein, Heterotrimeric, [D-Trp7910]-SubstanceP, GPAnt-2, analog, G, Protein, (Heterotrimeric), 1884, Tocris Bioscience

1 Citation for [D-Trp7,9,10]-Substance P

Citations are publications that use Tocris products. Selected citations for [D-Trp7,9,10]-Substance P include:

Nordman and Kabbani (2014) Microtubule dynamics at the growth cone are mediated by α7 nicotinic receptor activation of a Gαq and IP3 receptor pathway. Diabetes 28 2995 PMID: 24687992


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