Substance P analog that inhibits activation of Gq/11 by M1 muscarinic ACh receptors. Does not inhibit Gi/o activation by M2 ACh receptors.
(Modifications: Trp-7, Trp-9, Trp-10 = D-Trp, Met-11 = C-terminal Amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1588.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.63 mL||3.15 mL||6.29 mL|
|5 mM||0.13 mL||0.63 mL||1.26 mL|
|10 mM||0.06 mL||0.31 mL||0.63 mL|
|50 mM||0.01 mL||0.06 mL||0.13 mL|
References are publications that support the products' biological activity.
Mukai et al (1992) G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding. J.Biol.Chem. 267 16237 PMID: 1379592
If you know of a relevant reference for [D-Trp7,9,10]-Substance P, please let us know.
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Keywords: [D-Trp 7,9,10]-Substance P, supplier, inhibitors, inhibits, M1, ACh, receptor, activation, Gq/11, G-Protein, Heterotrimeric, [D-Trp7910]-SubstanceP, GPAnt-2, analog, G, Protein, (Heterotrimeric), G, Protein, (Heterotrimeric), Tocris Bioscience
1 Citation for [D-Trp7,9,10]-Substance P
Citations are publications that use Tocris products. Selected citations for [D-Trp7,9,10]-Substance P include:
Nordman and Kabbani (2014) Microtubule dynamics at the growth cone are mediated by α7 nicotinic receptor activation of a Gαq and IP3 receptor pathway. Diabetes 28 2995 PMID: 24687992
Do you know of a great paper that uses [D-Trp7,9,10]-Substance P from Tocris? If so please let us know.
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