Substance P analog that inhibits activation of Gq/11 by M1 muscarinic ACh receptors. Does not inhibit Gi/o activation by M2 ACh receptors.
(Modifications: Trp-7, Trp-9, Trp-10 = D-Trp, Met-11 = C-terminal Amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Mukai et al (1992) G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding. J.Biol.Chem. 267 16237 PMID: 1379592
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Keywords: [D-Trp 7,9,10]-Substance P, [D-Trp 7,9,10]-Substance P supplier, inhibitors, inhibits, M1, ACh, receptor, activation, Gq/11, G-Protein, Heterotrimeric, [D-Trp7910]-SubstanceP, GPAnt-2, analog, G, Protein, (Heterotrimeric), 1884, Tocris Bioscience
1 Citation for [D-Trp7,9,10]-Substance P
Citations are publications that use Tocris products. Selected citations for [D-Trp7,9,10]-Substance P include:
Nordman and Kabbani (2014) Microtubule dynamics at the growth cone are mediated by α7 nicotinic receptor activation of a Gαq and IP3 receptor pathway. Diabetes 28 2995 PMID: 24687992
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