[D-Trp7,9,10]-Substance P

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Cat.No. 1884 - [D-Trp 7,9,10]-Substance P | Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-D-Trp-Met-NH2 | CAS No. 89430-38-6
Description: Inhibits M1 ACh receptor activation of Gq/11
Alternative Names: GPAnt-2 analog
Citations (1)

Biological Activity

Substance P analog that inhibits activation of Gq/11 by M1 muscarinic ACh receptors. Does not inhibit Gi/o activation by M2 ACh receptors.

Technical Data

M. Wt 1588.89
Formula C79H105N21O13S

(Modifications: Trp-7, Trp-9, Trp-10 = D-Trp, Met-11 = C-terminal Amide)

Storage Store at -20°C
CAS Number 89430-38-6
PubChem ID 16143852
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1588.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.63 mL 3.15 mL 6.29 mL
5 mM 0.13 mL 0.63 mL 1.26 mL
10 mM 0.06 mL 0.31 mL 0.63 mL
50 mM 0.01 mL 0.06 mL 0.13 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Mukai et al (1992) G protein antagonists. A novel hydrophobic peptide competes with receptor for G protein binding. J.Biol.Chem. 267 16237 PMID: 1379592

If you know of a relevant reference for [D-Trp7,9,10]-Substance P, please let us know.

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Keywords: [D-Trp 7,9,10]-Substance P, supplier, inhibitors, inhibits, M1, ACh, receptor, activation, Gq/11, G-Protein, Heterotrimeric, [D-Trp7910]-SubstanceP, GPAnt-2, analog, G, Protein, (Heterotrimeric), G, Protein, (Heterotrimeric), Tocris Bioscience

1 Citation for [D-Trp7,9,10]-Substance P

Citations are publications that use Tocris products. Selected citations for [D-Trp7,9,10]-Substance P include:

Nordman and Kabbani (2014) Microtubule dynamics at the growth cone are mediated by α7 nicotinic receptor activation of a Gαq and IP3 receptor pathway. Diabetes 28 2995 PMID: 24687992

Do you know of a great paper that uses [D-Trp7,9,10]-Substance P from Tocris? If so please let us know.

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