D-Amphetamine sulfate

Pricing Availability   Qty
Description: Induces dopamine, 5-HT and noradrenalin release; also α7 nAChR antagonist
Alternative Names: Dextroamphetamine sulfate
Chemical Name: (+)-α-Methylphenethylamine hemisulfate salt
Purity: ≥99% (HPLC)
Citations (8)
Literature (2)

Biological Activity for D-Amphetamine sulfate

D-Amphetamine sulfate is a cNS stimulant. Targets monoamine transporters to elevate synaptic levels of noradrenalin, dopamine and serotonin. Also α7 nAChR antagonist.

Technical Data for D-Amphetamine sulfate

M. Wt 184.25
Formula C9H13N.1/2H2SO4
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 51-63-8
PubChem ID 5825
Smiles N[C@@H](C)CC1=CC=CC=C1.N[C@@H](C)CC2=CC=CC=C2.OS(O)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for D-Amphetamine sulfate

Solvent Max Conc. mg/mL Max Conc. mM
water 18.43 100

Preparing Stock Solutions for D-Amphetamine sulfate

The following data is based on the product molecular weight 184.25. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.43 mL 27.14 mL 54.27 mL
5 mM 1.09 mL 5.43 mL 10.85 mL
10 mM 0.54 mL 2.71 mL 5.43 mL
50 mM 0.11 mL 0.54 mL 1.09 mL

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Product Datasheets for D-Amphetamine sulfate

Certificate of Analysis / Product Datasheet
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References for D-Amphetamine sulfate

References are publications that support the biological activity of the product.

Barr et al (1999) Effects of withdrawal from an escalating dose schedule of d-Amphetamine on sexual behavior in the male rat. Pharmacol.Biochem.Behav. 64 597 PMID: 10548277

Cartmell et al (1999) The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-Amphetamine motor behaviors in rats. J.Pharmacol.Exp.Ther. 291 161 PMID: 10490900

Rothman and Baumann (2006) Balance between DA and serotonin release modulates behavioral effects of Amphetamine-type drugs. Ann.N.Y.Acad.Sci. 1074 245 PMID: 17105921

Garton et al (2018) Amphetamine enantiomers inhibit homomeric a7 nicotinic receptor through a competitive mechanism and within the intoxication levels in humans. Neuropharmacology PMID: 30359640

If you know of a relevant reference for D-Amphetamine sulfate, please let us know.

Keywords: D-Amphetamine sulfate, D-Amphetamine sulfate supplier, Induces, 5-HT, dopamine, noradrenaline, release, Serotonin, 5-Hydroxytryptamine, amphetamine, Dextroamphetamine, sulfate, Dopaminergic-Related, Adrenergic, Related, Compounds, 5-HT-Related, 5-HT3, Receptors, Nicotinic, (a7), 2813, Tocris Bioscience

8 Citations for D-Amphetamine sulfate

Citations are publications that use Tocris products. Selected citations for D-Amphetamine sulfate include:

Sánchez-Blázquez et al (2018) Sigma 1 Receptor Antagonists Inhibit Manic-Like Behaviors in Two Congenital Strains of Mice. Int J Neuropsychopharmacol 21 938 PMID: 29860313

Rennekamp et al (2016) σ1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol 12 552 PMID: 27239788

Palmér et al (2017) Action sequencing in the spontaneous swimming behavior of zebrafish larvae - implications for drug development. Sci Rep 7 3191 PMID: 28600565

Beerepoot et al (2016) Pharmacological Chaperones of the DA Transporter Rescue DA Transporter Deficiency Syndrome Mutations in Heterologous Cells. J Biol Chem 291 22053 PMID: 27555326

Do you know of a great paper that uses D-Amphetamine sulfate from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Dopamine Receptors Scientific Review

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.