D-64131

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Cat.No. 1643 - D-64131 | C16H13NO2 | CAS No. 74588-78-6
Description: Tubulin polymerization inhibitor. Antitumor in vivo
Chemical Name: (5-Methoxy-1H-indol-2-yl)phenylmethanone
Purity: ≥99% (HPLC)
Datasheet
Citations
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Literature

Biological Activity

Novel inhibitor of tubulin polymerization; cytotoxic and inhibits tumor cell proliferation in vitro (IC50 = 74 nM). Prevents growth of tumor models in mice following oral administration in vivo.

Technical Data

M. Wt 251.28
Formula C16H13NO2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 74588-78-6
PubChem ID 3921152
InChI Key ICMIJSRDISNKOC-UHFFFAOYSA-N
Smiles COC1=CC=C2NC(=CC2=C1)C(=O)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.13 100
ethanol 5.03 20

Preparing Stock Solutions

The following data is based on the product molecular weight 251.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.98 mL 19.9 mL 39.8 mL
5 mM 0.8 mL 3.98 mL 7.96 mL
10 mM 0.4 mL 1.99 mL 3.98 mL
50 mM 0.08 mL 0.4 mL 0.8 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Beckers et al (2002) 2-aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors. Cancer Res. 62 3113 PMID: 12036922

Mahboobi et al (2001) Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, antimitotic agents. J.Med.Chem. 44 4535 PMID: 11741473


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Keywords: D-64131, supplier, inhibitors, inhibits, tubulin, polymerization, Antitumor, Tau, Microtubules, Mitosis, Microtubules, Mitosis, Microtubules, Tocris Bioscience

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