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Submit ReviewD-64131
Discontinued Product
D-64131 (Cat. No. 1643) has been withdrawn from sale for commercial reasons.
Description: Tubulin polymerization inhibitor. Antitumor in vivo
Chemical Name: (5-Methoxy-1H-indol-2-yl)phenylmethanone
Purity: ≥99% (HPLC)
Biological Activity for D-64131
D-64131 is a novel inhibitor of tubulin polymerization; cytotoxic and inhibits tumor cell proliferation in vitro (IC50 = 74 nM). Prevents growth of tumor models in mice following oral administration in vivo.
Technical Data for D-64131
| M. Wt | 251.28 |
| Formula | C16H13NO2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 74588-78-6 |
| PubChem ID | 3921152 |
| InChI Key | ICMIJSRDISNKOC-UHFFFAOYSA-N |
| Smiles | COC1=CC=C2NC(=CC2=C1)C(=O)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for D-64131
References for D-64131
References are publications that support the biological activity of the product.
Beckers et al (2002) 2-aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors. Cancer Res. 62 3113 PMID: 12036922
Mahboobi et al (2001) Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, antimitotic agents. J.Med.Chem. 44 4535 PMID: 11741473
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Keywords: D-64131, D-64131 supplier, inhibitors, inhibits, tubulin, polymerization, Antitumor, Tau, Microtubules, Mitosis, 1643, Tocris Bioscience
Citations for D-64131
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Currently there are no citations for D-64131.
Reviews for D-64131
Average Rating: 5 (Based on 1 Review.)
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The antitumoral efficacy of D-64131 in comparison to paclitaxel and vincristine.
By
Anonymous on 12/23/2019
Species: Human
The antitumoral efficacy of D-64131 in comparison to paclitaxel and vincristine was evaluated in resistance mediated by the MRP and in human tumor cells with resistance to cisplatin, the topoisomerase I inhibitor SN-38 (7-ethyl-10-hydroxycamptothecin) and the thymidylate synthase inhibitors 5-fluorouracil and raltitexed.
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