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Description: Tubulin polymerization inhibitor. Antitumor in vivo
Chemical Name: (5-Methoxy-1H-indol-2-yl)phenylmethanone
Purity: ≥99% (HPLC)
Biological Activity
Novel inhibitor of tubulin polymerization; cytotoxic and inhibits tumor cell proliferation in vitro (IC50 = 74 nM). Prevents growth of tumor models in mice following oral administration in vivo.
Technical Data
| M. Wt | 251.28 |
| Formula | C16H13NO2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 74588-78-6 |
| PubChem ID | 3921152 |
| InChI Key | ICMIJSRDISNKOC-UHFFFAOYSA-N |
| Smiles | COC1=CC=C2NC(=CC2=C1)C(=O)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 5.03 | 20 | |
| DMSO | 25.13 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 251.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.98 mL | 19.9 mL | 39.8 mL |
| 5 mM | 0.8 mL | 3.98 mL | 7.96 mL |
| 10 mM | 0.4 mL | 1.99 mL | 3.98 mL |
| 50 mM | 0.08 mL | 0.4 mL | 0.8 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Beckers et al (2002) 2-aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors. Cancer Res. 62 3113 PMID: 12036922
Mahboobi et al (2001) Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, antimitotic agents. J.Med.Chem. 44 4535 PMID: 11741473
If you know of a relevant reference for D-64131, please let us know.
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Keywords: D-64131, D-64131 supplier, inhibitors, inhibits, tubulin, polymerization, Antitumor, Tau, Microtubules, Mitosis, 1643, Tocris Bioscience
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