D-64131

Name: D-64131
Brand: Tocris Bioscience
SKU: 1643
Rating: 5 (1 reviews)

Cat. No. 1643 1 Review Submit a Review Datasheet / COA / SDS

Discontinued Product

D-64131 (Cat. No. 1643) has been withdrawn from sale for commercial reasons.

Description: Tubulin polymerization inhibitor. Antitumor in vivo

Chemical Name: (5-Methoxy-1H-indol-2-yl)phenylmethanone

Purity: ≥99% (HPLC)

Datasheet

Citations

Reviews (1)

Literature (3)

Biological Activity Technical Data Datasheets References

Biological Activity for D-64131

D-64131 is a novel inhibitor of tubulin polymerization; cytotoxic and inhibits tumor cell proliferation in vitro (IC₅₀ = 74 nM). Prevents growth of tumor models in mice following oral administration in vivo.

Technical Data for D-64131

M. Wt	251.28
Formula	C₁₆H₁₃NO₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	74588-78-6
PubChem ID	3921152
InChI Key	ICMIJSRDISNKOC-UHFFFAOYSA-N
Smiles	COC1=CC=C2NC(=CC2=C1)C(=O)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for D-64131

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for D-64131

References are publications that support the biological activity of the product.

Beckers et al (2002) 2-aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors. Cancer Res. 62 3113 PMID: 12036922

Mahboobi et al (2001) Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, antimitotic agents. J.Med.Chem. 44 4535 PMID: 11741473

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Keywords: D-64131, D-64131 supplier, inhibitors, inhibits, tubulin, polymerization, Antitumor, Tau, Microtubules, Mitosis, 1643, Tocris Bioscience

Citations for D-64131

Citations are publications that use Tocris products.

Currently there are no citations for D-64131.

Reviews for D-64131

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The antitumoral efficacy of D-64131 in comparison to paclitaxel and vincristine.

By Anonymous on 12/23/2019

Species: Human

The antitumoral efficacy of D-64131 in comparison to paclitaxel and vincristine was evaluated in resistance mediated by the MRP and in human tumor cells with resistance to cisplatin, the topoisomerase I inhibitor SN-38 (7-ethyl-10-hydroxycamptothecin) and the thymidylate synthase inhibitors 5-fluorouracil and raltitexed.