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Submit ReviewCystamine dihydrochloride
Description: Transglutaminase inhibitor; neuroprotective
Chemical Name: 2,2'-Diaminodiethyl disulfide dihydrochloride
Biological Activity
Transglutaminase inhibitor. Attenuates cell death induced by 3-nitropropionic acid (Cat. No. 4849) in Huntington's disease (HD) striatal cells. Also decreases aggregated and cross-linked huntingtin in transfected cells, and increases brain levels of BDNF. Shown to extend survival and improve motor performance in transgenic HD mice. Neuroprotective.
Technical Data
| M. Wt | 225.2 |
| Formula | C4H12N2S2.2HCl |
| Storage | Desiccate at RT |
| CAS Number | 56-17-7 |
| PubChem ID | 5941 |
| InChI Key | YUFRRMZSSPQMOS-UHFFFAOYSA-N |
| Smiles | NCCSSCCN.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 22.52 | 100 | |
| DMSO | 22.52 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 225.2. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.44 mL | 22.2 mL | 44.4 mL |
| 5 mM | 0.89 mL | 4.44 mL | 8.88 mL |
| 10 mM | 0.44 mL | 2.22 mL | 4.44 mL |
| 50 mM | 0.09 mL | 0.44 mL | 0.89 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Borrell-Pages et al (2006) Cystamine and cyste. increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase. J.Clin.Invest. 116 1410 PMID: 16604191
Dedeoglu et al (2002) Therapeutic effects of cystamine in a murine model of Huntington's disease. J.Neurosci. 22 8942 PMID: 12388601
Mao et al (2006) Cystamine and cyste. prevent 3-NP-induced mitochondrial depolarization of Huntington's disease knock-in striatal cells. Eur.J.Neurosci. 23 1701 PMID: 16623826
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Keywords: Cystamine dihydrochloride, Cystamine dihydrochloride supplier, transglutaminase, TG, inhibitors, inhibits, neuroprotective, Huntingtons, Huntington's, disease, Other, Transferases, 4981, Tocris Bioscience
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