Cystamine dihydrochloride

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Cat.No. 4981 - Cystamine dihydrochloride | C4H12N2S2.2HCl | CAS No. 56-17-7
Description: Transglutaminase inhibitor; neuroprotective
Chemical Name: 2,2'-Diaminodiethyl disulfide dihydrochloride
Datasheet
Citations
Literature

Biological Activity

Transglutaminase inhibitor. Attenuates cell death induced by 3-nitropropionic acid (Cat. No. 4849) in Huntington's disease (HD) striatal cells. Also decreases aggregated and cross-linked huntingtin in transfected cells, and increases brain levels of BDNF. Shown to extend survival and improve motor performance in transgenic HD mice. Neuroprotective.

Technical Data

M. Wt 225.2
Formula C4H12N2S2.2HCl
Storage Desiccate at RT
CAS Number 56-17-7
PubChem ID 5941
InChI Key YUFRRMZSSPQMOS-UHFFFAOYSA-N
Smiles NCCSSCCN.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.52 100
water 22.52 100

Preparing Stock Solutions

The following data is based on the product molecular weight 225.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.44 mL 22.2 mL 44.4 mL
5 mM 0.89 mL 4.44 mL 8.88 mL
10 mM 0.44 mL 2.22 mL 4.44 mL
50 mM 0.09 mL 0.44 mL 0.89 mL

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References

References are publications that support the products' biological activity.

Borrell-Pages et al (2006) Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase. J.Clin.Invest. 116 1410 PMID: 16604191

Dedeoglu et al (2002) Therapeutic effects of cystamine in a murine model of Huntington's disease. J.Neurosci. 22 8942 PMID: 12388601

Mao et al (2006) Cystamine and cysteamine prevent 3-NP-induced mitochondrial depolarization of Huntington's disease knock-in striatal cells. Eur.J.Neurosci. 23 1701 PMID: 16623826


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Keywords: transglutaminase TG inhibitors inhibits neuroprotective Huntingtons Huntington's disease Other Transferases

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