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Submit ReviewCystamine dihydrochloride
Description: Transglutaminase inhibitor; neuroprotective
Chemical Name: 2,2'-Diaminodiethyl disulfide dihydrochloride
Biological Activity for Cystamine dihydrochloride
Cystamine dihydrochloride is a transglutaminase inhibitor. Attenuates cell death induced by 3-nitropropionic acid (Cat. No. 4849) in Huntington's disease (HD) striatal cells. Also decreases aggregated and cross-linked huntingtin in transfected cells, and increases brain levels of BDNF. Shown to extend survival and improve motor performance in transgenic HD mice. Neuroprotective.
Technical Data for Cystamine dihydrochloride
| M. Wt | 225.2 |
| Formula | C4H12N2S2.2HCl |
| Storage | Desiccate at RT |
| CAS Number | 56-17-7 |
| PubChem ID | 5941 |
| InChI Key | YUFRRMZSSPQMOS-UHFFFAOYSA-N |
| Smiles | NCCSSCCN.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Cystamine dihydrochloride
References for Cystamine dihydrochloride
References are publications that support the biological activity of the product.
Borrell-Pages et al (2006) Cystamine and cyste. increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase. J.Clin.Invest. 116 1410 PMID: 16604191
Dedeoglu et al (2002) Therapeutic effects of cystamine in a murine model of Huntington's disease. J.Neurosci. 22 8942 PMID: 12388601
Mao et al (2006) Cystamine and cyste. prevent 3-NP-induced mitochondrial depolarization of Huntington's disease knock-in striatal cells. Eur.J.Neurosci. 23 1701 PMID: 16623826
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Keywords: Cystamine dihydrochloride, Cystamine dihydrochloride supplier, transglutaminase, TG, inhibitors, inhibits, neuroprotective, Huntingtons, Huntington's, disease, Other, Transferases, 4981, Tocris Bioscience
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