Discontinued Product

Curcumin (Cat. No. 2841) has been withdrawn from sale for commercial reasons.
Description: Antitumor, anti-inflammatory and antioxidant
Alternative Names: Diferuloylmethane
Chemical Name: (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
Citations (5)
Literature (1)
Pathways (1)

Biological Activity for Curcumin

Curcumin is an antitumor, anti-inflammatory and antioxidant agent. Downregulates expression of reactive-oxygen-generating enzymes (cyclooxygenase, lipoxygenase, iNOS), TNFα, IL-1, IL-6, PKC, EGFR, NF-κB, IκB kinase and more. Upregulates expression of PPARγ, p53, Nrf2. Also displays antimicrobial, antidiabetic neuro- and cardioprotective properties in vivo.

Technical Data for Curcumin

M. Wt 368.38
Formula C21H20O6
Storage Store at -20°C
CAS Number 458-37-7
PubChem ID 969516
Smiles O=C(CC(/C=C/C2=CC=C(O)C(OC)=C2)=O)/C=C/C1=CC(OC)=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Curcumin

References are publications that support the biological activity of the product.

Kuttan et al (2007) Antitumour, anti-invasion, and antimetastatic effects of curcumin. Adv.Exp.Med.Biol. 595 173 PMID: 17569210

Cole et al (2007) Neuroprotective effects of curcumin. Adv.Exp.Med.Biol. 595 197 PMID: 17569212

Lin (2007) Molecular targets of curcumin. Adv.Exp.Med.Biol. 595 227 PMID: 17569214

Miriyala et al (2007) Cardioprotective effects of curcumin. Adv.Exp.Med.Biol. 595 359 PMID: 17569220

Aggarwal and Sung (2009) Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. TiPS 30 85 PMID: 19110321

Keywords: Curcumin, Curcumin supplier, Antitumor, anti-inflammatory, antioxidant, Apoptosis, Inducer, nrf2, Diferuloylmethane, Inducers, Antioxidants, Nrf2, 2841, Tocris Bioscience

5 Citations for Curcumin

Citations are publications that use Tocris products. Selected citations for Curcumin include:

Efthymiou et al (2015) Rescue of an in vitro neuron phenotype identified in Niemann-Pick disease, type C1 induced pluripotent stem cell-derived neurons by modulating the WNT pathway and calcium signaling. J Neurosci 4 230 PMID: 25637190

Boija et al (2017) CBP Regulates Recruitment and Release of Promoter-Proximal RNA Polymerase II. Mol Cell 68 491 PMID: 29056321

Chang et al (2015) Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin. Sci Rep 5 10256 PMID: 26194093

Chen et al (2012) Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT. Int J Mol Med 30 1021 PMID: 22922731

Han et al (2012) Analgesic effects of intrathecal curcumin in the rat formalin test. Korean J Pain 25 43252 PMID: 22259709

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Curcumin

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.