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Antitumor, anti-inflammatory and antioxidant agent. Downregulates expression of reactive-oxygen-generating enzymes (cyclooxygenase, lipoxygenase, iNOS), TNFα, IL-1, IL-6, PKC, EGFR, NF-κB, IκB kinase and more. Upregulates expression of PPARγ, p53, Nrf2. Also displays antimicrobial, antidiabetic neuro- and cardioprotective properties in vivo.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 368.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||27.15 mL||135.73 mL||271.46 mL|
|0.5 mM||5.43 mL||27.15 mL||54.29 mL|
|1 mM||2.71 mL||13.57 mL||27.15 mL|
|5 mM||0.54 mL||2.71 mL||5.43 mL|
References are publications that support the biological activity of the product.
Kuttan et al (2007) Antitumour, anti-invasion, and antimetastatic effects of curcumin. Adv.Exp.Med.Biol. 595 173 PMID: 17569210
Cole et al (2007) Neuroprotective effects of curcumin. Adv.Exp.Med.Biol. 595 197 PMID: 17569212
Lin (2007) Molecular targets of curcumin. Adv.Exp.Med.Biol. 595 227 PMID: 17569214
Miriyala et al (2007) Cardioprotective effects of curcumin. Adv.Exp.Med.Biol. 595 359 PMID: 17569220
Aggarwal and Sung (2009) Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. TiPS 30 85 PMID: 19110321
If you know of a relevant reference for Curcumin, please let us know.
Keywords: Curcumin, Curcumin supplier, Antitumor, anti-inflammatory, antioxidant, Apoptosis, Inducer, nrf2, Diferuloylmethane, Inducers, Antioxidants, Nrf2, 2841, Tocris Bioscience
5 Citations for Curcumin
Citations are publications that use Tocris products. Selected citations for Curcumin include:
Efthymiou et al (2015) Rescue of an in vitro neuron phenotype identified in Niemann-Pick disease, type C1 induced pluripotent stem cell-derived neurons by modulating the WNT pathway and calcium signaling. J Neurosci 4 230 PMID: 25637190
Chen et al (2012) Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT. Int J Mol Med 30 1021 PMID: 22922731
Han et al (2012) Analgesic effects of intrathecal curcumin in the rat formalin test. Korean J Pain 25 43252 PMID: 22259709
Chang et al (2015) Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin. Sci Rep 5 10256 PMID: 26194093
Boija et al (2017) CBP Regulates Recruitment and Release of Promoter-Proximal RNA Polymerase II. Mol Cell 68 491 PMID: 29056321
Do you know of a great paper that uses Curcumin from Tocris? Please let us know.
Reviews for Curcumin
Average Rating: 5 (Based on 1 Review.)
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used at 10um to activate anti-oxidant response in mouse macrophages
Literature in this Area
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Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.