Curcumin

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Cat.No. 2841 - Curcumin | C21H20O6 | CAS No. 458-37-7
Description: Antitumor, anti-inflammatory and antioxidant
Alternative Names: Diferuloylmethane
Chemical Name: (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
Datasheet
Citations (5)
Reviews (1)
Literature (2)
Pathways (1)

Biological Activity

Antitumor, anti-inflammatory and antioxidant agent. Downregulates expression of reactive-oxygen-generating enzymes (cyclooxygenase, lipoxygenase, iNOS), TNFα, IL-1, IL-6, PKC, EGFR, NF-κB, IκB kinase and more. Upregulates expression of PPARγ, p53, Nrf2. Also displays antimicrobial, antidiabetic neuro- and cardioprotective properties in vivo.

Technical Data

M. Wt 368.38
Formula C21H20O6
Storage Store at -20°C
CAS Number 458-37-7
PubChem ID 969516
InChI Key VFLDPWHFBUODDF-FCXRPNKRSA-N
Smiles O=C(CC(/C=C/C2=CC=C(O)C(OC)=C2)=O)/C=C/C1=CC(OC)=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.68 10
ethanol 1.84 5

Preparing Stock Solutions

The following data is based on the product molecular weight 368.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.15 mL 135.73 mL 271.46 mL
0.5 mM 5.43 mL 27.15 mL 54.29 mL
1 mM 2.71 mL 13.57 mL 27.15 mL
5 mM 0.54 mL 2.71 mL 5.43 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Kuttan et al (2007) Antitumour, anti-invasion, and antimetastatic effects of curcumin. Adv.Exp.Med.Biol. 595 173 PMID: 17569210

Cole et al (2007) Neuroprotective effects of curcumin. Adv.Exp.Med.Biol. 595 197 PMID: 17569212

Lin (2007) Molecular targets of curcumin. Adv.Exp.Med.Biol. 595 227 PMID: 17569214

Miriyala et al (2007) Cardioprotective effects of curcumin. Adv.Exp.Med.Biol. 595 359 PMID: 17569220

Aggarwal and Sung (2009) Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. TiPS 30 85 PMID: 19110321


If you know of a relevant reference for Curcumin, please let us know.

Keywords: Curcumin, Curcumin supplier, Antitumor, anti-inflammatory, antioxidant, Apoptosis, Inducer, nrf2, Diferuloylmethane, Inducers, Antioxidants, Nrf2, 2841, Tocris Bioscience

5 Citations for Curcumin

Citations are publications that use Tocris products. Selected citations for Curcumin include:

Chen et al (2012) Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT. Int J Mol Med 30 1021 PMID: 22922731

Han et al (2012) Analgesic effects of intrathecal curcumin in the rat formalin test. Korean J Pain 25 43252 PMID: 22259709

Chang et al (2015) Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin. Sci Rep 5 10256 PMID: 26194093

Boija et al (2017) CBP Regulates Recruitment and Release of Promoter-Proximal RNA Polymerase II. Mol Cell 68 491 PMID: 29056321


Do you know of a great paper that uses Curcumin from Tocris? Please let us know.

Reviews for Curcumin

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Curcumin treatment of mouse macrophages.
By Anonymous on 09/24/2019
Assay Type: In Vitro
Species: Mouse
Cell Line/Tissue: macrophage

used at 10um to activate anti-oxidant response in mouse macrophages


Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Curcumin

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.