Curcumin

Pricing Availability Delivery Time Qty
Cat.No. 2841 - Curcumin | C21H20O6 | CAS No. 458-37-7
Description: Antitumor, anti-inflammatory and antioxidant
Alternative Names: Diferuloylmethane
Chemical Name: (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
Datasheet
Citations (1)
Literature
Pathways

Biological Activity

Antitumor, anti-inflammatory and antioxidant agent. Downregulates expression of reactive-oxygen-generating enzymes (cyclooxygenase, lipoxygenase, iNOS), TNFα, IL-1, IL-6, PKC, EGFR, NF-κB, IκB kinase and more. Upregulates expression of PPARγ, p53, Nrf2. Also displays antimicrobial, antidiabetic neuro- and cardioprotective properties in vivo.

Technical Data

M. Wt 368.38
Formula C21H20O6
Storage Store at -20°C
CAS Number 458-37-7
PubChem ID 969516
InChI Key VFLDPWHFBUODDF-FCXRPNKRSA-N
Smiles O=C(CC(/C=C/C2=CC=C(O)C(OC)=C2)=O)/C=C/C1=CC(OC)=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.68 10
ethanol 1.84 5

Preparing Stock Solutions

The following data is based on the product molecular weight 368.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.71 mL 13.57 mL 27.15 mL
5 mM 0.54 mL 2.71 mL 5.43 mL
10 mM 0.27 mL 1.36 mL 2.71 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kuttan et al (2007) Antitumour, anti-invasion, and antimetastatic effects of curcumin. Adv.Exp.Med.Biol. 595 173 PMID: 17569210

Cole et al (2007) Neuroprotective effects of curcumin. Adv.Exp.Med.Biol. 595 197 PMID: 17569212

Lin (2007) Molecular targets of curcumin. Adv.Exp.Med.Biol. 595 227 PMID: 17569214

Miriyala et al (2007) Cardioprotective effects of curcumin. Adv.Exp.Med.Biol. 595 359 PMID: 17569220

Aggarwal and Sung (2009) Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. TiPS 30 85 PMID: 19110321


If you know of a relevant reference for Curcumin, please let us know.

Keywords: Curcumin, supplier, Antitumor, anti-inflammatory, antioxidant, Apoptosis, Inducer, nrf2, Diferuloylmethane, Apoptosis, Inducers, Tocris Bioscience

1 Citation for Curcumin

Citations are publications that use Tocris products. Selected citations for Curcumin include:

Efthymiou et al (2015) Rescue of an in vitro neuron phenotype identified in Niemann-Pick disease, type C1 induced pluripotent stem cell-derived neurons by modulating the WNT pathway and calcium signaling. J Neurosci 4 230 PMID: 25637190


Do you know of a great paper that uses Curcumin from Tocris? If so please let us know.

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Reviews

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Curcumin

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.

Protocols

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