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CU CPT 9a
Biological Activity for CU CPT 9a
CU CPT 9a is a potent TLR8 inhibitor (IC50 = 0.5 nM and Kd = 21 nM). Stabilizes the TLR8 dimer in its resting state, preventing activation. Suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells.
Sold under license from the University of Colorado
Compound Libraries for CU CPT 9a
Technical Data for CU CPT 9a
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CU CPT 9a
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for CU CPT 9a
The following data is based on the product molecular weight 265.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.77 mL||18.85 mL||37.69 mL|
|5 mM||0.75 mL||3.77 mL||7.54 mL|
|10 mM||0.38 mL||1.88 mL||3.77 mL|
|50 mM||0.08 mL||0.38 mL||0.75 mL|
References for CU CPT 9a
References are publications that support the biological activity of the product.
Zhang et al (2018) Small-molecule inhibition of TLR8 through stabilization of its resting state. Nat.Chem.Biol. 14 58 PMID: 29155428
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Citations for CU CPT 9a
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Literature in this Area
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