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Description: Highly potent TLR8 inhibitor
Chemical Name: 2-Methyl-4-(7-methoxy-4-quinolinyl)phenol
Purity: ≥98% (HPLC)
Pathways (1)

Biological Activity for CU CPT 9a

CU CPT 9a is a potent TLR8 inhibitor (IC50 = 0.5 nM and Kd = 21 nM). Stabilizes the TLR8 dimer in its resting state, preventing activation. Suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells.

Licensing Information

Sold under license from the University of Colorado

Compound Libraries for CU CPT 9a

CU CPT 9a is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for CU CPT 9a

M. Wt 265.31
Formula C17H15NO2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2165340-32-7
PubChem ID 135567383
Smiles COC1=CC2=C(C(C3=CC(C)=C(C=C3)O)=CC=N2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CU CPT 9a

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 26.53 100
ethanol 5.31 20

Preparing Stock Solutions for CU CPT 9a

The following data is based on the product molecular weight 265.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.77 mL 18.85 mL 37.69 mL
5 mM 0.75 mL 3.77 mL 7.54 mL
10 mM 0.38 mL 1.88 mL 3.77 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

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References for CU CPT 9a

References are publications that support the biological activity of the product.

Zhang et al (2018) Small-molecule inhibition of TLR8 through stabilization of its resting state. Nat.Chem.Biol. 14 58 PMID: 29155428

If you know of a relevant reference for CU CPT 9a, please let us know.

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Citations for CU CPT 9a

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Pathways for CU CPT 9a

Toll-like Receptor Signaling Pathway

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.