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CU CPT 4a
Biological Activity for CU CPT 4a
CU CPT 4a is a selective TLR3 inhibitor (IC50 = 3.44 μM in RAW 264.7 cells); suppresses downstream signaling pathways mediated by the TLR3/dsRNA complex, inhibiting TNF-α and IL-1β production in whole cells. Reduces death of crypt cells and improves gastrointestinal syndrome in mice.
Sold under license from the University of Colorado
Compound Libraries for CU CPT 4a
Technical Data for CU CPT 4a
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CU CPT 4a
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for CU CPT 4a
The following data is based on the product molecular weight 377.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.65 mL||13.23 mL||26.47 mL|
|5 mM||0.53 mL||2.65 mL||5.29 mL|
|10 mM||0.26 mL||1.32 mL||2.65 mL|
|50 mM||0.05 mL||0.26 mL||0.53 mL|
References for CU CPT 4a
References are publications that support the biological activity of the product.
Cheng et al (2011) Small-molecule inhibitors of the TLR3/dsRNA complex. J.Am.Chem.Soc. 133 3764 PMID: 21355588
Takemura et al (2014) Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome. Nat.Commun. 18 PMID: 24637670
If you know of a relevant reference for CU CPT 4a, please let us know.
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Keywords: CU CPT 4a, CU CPT 4a supplier, CUCPT4a, toll, like, receptors, ligands, antagonists, TLR3, inflammation, TNF-, #945, TNF-1, TNF-alpha, IL-#946, IL-b, IL-beta, Toll-like, Receptors, 4883, Tocris Bioscience
2 Citations for CU CPT 4a
Citations are publications that use Tocris products. Selected citations for CU CPT 4a include:
Grigoryeva et al (2021) Human macrophages utilize a wide range of pathogen recognition receptors to recognize Legionella pneumophila, including Toll-Like Receptor 4 engaging Legionella lipopolysaccharide and the Toll-like Receptor 3 nucleic-acid sensor PLoS Pathog 17 e1009781 PMID: 34280250
Gerhard et al (2020) Ribonuclease 1 attenuates septic cardiomyopathy and cardiac apoptosis in a murine model of polymicrobial sepsis. JCI Insight 5 PMID: 32213712
Do you know of a great paper that uses CU CPT 4a from Tocris? Please let us know.
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Literature in this Area
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