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Description: Selective TLR3 inhibitor
Chemical Name: N-[(3-Chloro-6-fluorobenzo[b]thien-2-yl)carbonyl]-D-phenylalanine
Purity: ≥98% (HPLC)
Citations (2)
Pathways (1)

Biological Activity for CU CPT 4a

CU CPT 4a is a selective TLR3 inhibitor (IC50 = 3.44 μM in RAW 264.7 cells); suppresses downstream signaling pathways mediated by the TLR3/dsRNA complex, inhibiting TNF-α and IL-1β production in whole cells. Reduces death of crypt cells and improves gastrointestinal syndrome in mice.

Licensing Information

Sold under license from the University of Colorado

Compound Libraries for CU CPT 4a

CU CPT 4a is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for CU CPT 4a

M. Wt 377.82
Formula C18H13ClFNO3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1279713-77-7
PubChem ID 53242268
Smiles O=C(N[C@H](CC3=CC=CC=C3)[C@@](O)=O)C2=C(Cl)C1=CC=C(F)C=C1S2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CU CPT 4a

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 37.78 100

Preparing Stock Solutions for CU CPT 4a

The following data is based on the product molecular weight 377.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.65 mL 13.23 mL 26.47 mL
5 mM 0.53 mL 2.65 mL 5.29 mL
10 mM 0.26 mL 1.32 mL 2.65 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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Product Datasheets for CU CPT 4a

Certificate of Analysis / Product Datasheet
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References for CU CPT 4a

References are publications that support the biological activity of the product.

Cheng et al (2011) Small-molecule inhibitors of the TLR3/dsRNA complex. J.Am.Chem.Soc. 133 3764 PMID: 21355588

Takemura et al (2014) Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome. Nat.Commun. 18 PMID: 24637670

If you know of a relevant reference for CU CPT 4a, please let us know.

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Keywords: CU CPT 4a, CU CPT 4a supplier, CUCPT4a, toll, like, receptors, ligands, antagonists, TLR3, inflammation, TNF-, #945, TNF-1, TNF-alpha, IL-#946, IL-b, IL-beta, Toll-like, Receptors, 4883, Tocris Bioscience

2 Citations for CU CPT 4a

Citations are publications that use Tocris products. Selected citations for CU CPT 4a include:

Gerhard et al (2020) Ribonuclease 1 attenuates septic cardiomyopathy and cardiac apoptosis in a murine model of polymicrobial sepsis. JCI Insight 5 PMID: 32213712

Grigoryeva et al (2021) Human macrophages utilize a wide range of pathogen recognition receptors to recognize Legionella pneumophila, including Toll-Like Receptor 4 engaging Legionella lipopolysaccharide and the Toll-like Receptor 3 nucleic-acid sensor PLoS Pathog 17 e1009781 PMID: 34280250

Do you know of a great paper that uses CU CPT 4a from Tocris? Please let us know.

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Pathways for CU CPT 4a

Toll-like Receptor Signaling Pathway

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.