CU CPT 4a

Pricing Availability Delivery Time Qty
Cat.No. 4883 - CU CPT 4a | C18H13ClFNO3S | CAS No. 1279713-77-7
Description: Selective TLR3 inhibitor
Chemical Name: N-[(3-Chloro-6-fluorobenzo[b]thien-2-yl)carbonyl]-D-phenylalanine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

Selective TLR3 inhibitor (IC50 = 3.44 μM in RAW 264.7 cells); suppresses downstream signaling pathways mediated by the TLR3/dsRNA complex, inhibiting TNF-α and IL-1β production in whole cells. Reduces death of crypt cells and improves gastrointestinal syndrome in mice.

Licensing Information

Sold under license from the University of Colorado

Compound Libraries

CU CPT 4a is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 377.82
Formula C18H13ClFNO3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1279713-77-7
PubChem ID 53242268
InChI Key IAASQMCXDRISAV-CYBMUJFWSA-N
Smiles O=C(N[C@H](CC3=CC=CC=C3)[C@@](O)=O)C2=C(Cl)C1=CC=C(F)C=C1S2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 18.89 50
DMSO 37.78 100

Preparing Stock Solutions

The following data is based on the product molecular weight 377.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.65 mL 13.23 mL 26.47 mL
5 mM 0.53 mL 2.65 mL 5.29 mL
10 mM 0.26 mL 1.32 mL 2.65 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Cheng et al (2011) Small-molecule inhibitors of the TLR3/dsRNA complex. J.Am.Chem.Soc. 133 3764 PMID: 21355588

Takemura et al (2014) Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome. Nat.Commun. 18 PMID: 24637670


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Keywords: CU CPT 4a, supplier, CUCPT4a, toll, like, receptors, ligands, antagonists, TLR3, inflammation, TNF-, #945, TNF-1, TNF-alpha, IL-#946, IL-b, IL-beta, Toll-like, Receptors, Toll-like, Receptors, Tocris Bioscience

Citations for CU CPT 4a

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Pathways for CU CPT 4a

Toll-like Receptor

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.