You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for CRBN-6-5-5-VHL
CRBN-6-5-5-VHL is a potent and selective cereblon Degrader (PROTAC®) (DC50 = 1.5 nM). Induces complete degradation of cereblon in MM1S cells. Comprises a cereblon E3 ligase ligand joined by a linker to a ligand for the E3 ligase VHL. Cell-permeable.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Application of CRBN-6-5-5-VHL in MM1S cells for CRBN-6-5-5-VHL
Western blot data showing potent knockdown of Cereblon (CRBN) mediated by the Degrader: CRBN-6-5-5-VHL in MM1S cells after 16 h incubation. IKZF1 (Ikaros) and IKZF3 (Aiolos) are transcription factors and neosubstrates of Cereblon. Application of CRBN-6-5-5-VHL does not result in degradation of these proteins. Pom; Pomalidomide.
Data courtesy of Christian Steinebach, University of Bonn.
Technical Data for CRBN-6-5-5-VHL
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CRBN-6-5-5-VHL
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for CRBN-6-5-5-VHL
The following data is based on the product molecular weight 972.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.03 mL||5.14 mL||10.29 mL|
|5 mM||0.21 mL||1.03 mL||2.06 mL|
|10 mM||0.1 mL||0.51 mL||1.03 mL|
|50 mM||0.02 mL||0.1 mL||0.21 mL|
References for CRBN-6-5-5-VHL
References are publications that support the biological activity of the product.
Steinebach et al (2019) PROTAC-mediated crosstalk between E3 ligases. Chem.Commun.(Camb) 55 1821 PMID: 30672516
If you know of a relevant reference for CRBN-6-5-5-VHL, please let us know.
View Related Products by Target
Keywords: CRBN-6-5-5-VHL, CRBN-6-5-5-VHL supplier, PROTACs, proteolysis, targeting, chimeras, active, Degraders, degrades, VHL, von, Hippel, Lindau, Cereblon, CRBN, PROTAC, targeted, protein, degradation, tpd, Active, Ubiquitin, E3, Ligases, 6948, Tocris Bioscience
Citations for CRBN-6-5-5-VHL
Citations are publications that use Tocris products.
Currently there are no citations for CRBN-6-5-5-VHL. Do you know of a great paper that uses CRBN-6-5-5-VHL from Tocris? Please let us know.
Reviews for CRBN-6-5-5-VHL
There are currently no reviews for this product. Be the first to review CRBN-6-5-5-VHL and earn rewards!
Have you used CRBN-6-5-5-VHL?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Targeted Protein Degradation Research Product GuideUpdated
This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:
- Active Degraders
- TAG Degradation Platform
- Degrader Building Blocks
- Custom Degrader Services
- Ubiquitin-Proteasome System Proteins and Assays
- Assays for Protein Degradation
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Epigenetics in Cancer Poster
Adapted from the 2015 Cancer Product Guide Edition 3, this poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia