CP 99994 dihydrochloride

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Cat.No. 3417 - CP 99994 dihydrochloride | C19H24N2O.2HCl | CAS No. 145148-39-6
Description: High affinity NK1 antagonist
Chemical Name: (2S,3S)-N-[(2-Methoxyphenyl)methyl]-2-phenyl-3-piperidinamine dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

High affinity NK1 antagonist (Ki = 0.145 nM in vitro). Also displays high ex vivo binding potency in gerbil striatum (IC50 = 36.8 nM). Attenuates endothelium-dependent contraction induced by substance P.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

CP 99994 dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 369.33
Formula C19H24N2O.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 145148-39-6
PubChem ID 68466923
InChI Key WNHRFWPLRATIDT-FFUVTKDNSA-N
Smiles COC(C=CC=C3)=C3CN[C@@H]1[C@H]([C@]2=CC=CC=C2)NCCC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 36.93 100

Preparing Stock Solutions

The following data is based on the product molecular weight 369.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.71 mL 13.54 mL 27.08 mL
5 mM 0.54 mL 2.71 mL 5.42 mL
10 mM 0.27 mL 1.35 mL 2.71 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Shirahase et al (1995) Endothelium-dependent contraction in intrapulmonary arteries: mediation by endothelial NK1 receptors and TXA2. Br.J.Pharmacol. 115 1215 PMID: 7582548

Duffy et al (2002) Correlation of neurokinin (NK) 1 receptor occupancy in gerbil striatum with behavioral effects of NK1 antagonists. J.Pharmacol.Exp.Ther. 301 536 PMID: 11961054

Lindstrom et al (2007) Neurokinin 1 receptor antagonists: correlation between in vitro receptor interaction and in vivo efficacy. J.Pharmacol.Exp.Ther. 322 1286 PMID: 17575073


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1 Citation for CP 99994 dihydrochloride

Citations are publications that use Tocris products. Selected citations for CP 99994 dihydrochloride include:

Horn et al (2013) Novel dynamic measures of emetic behavior in musk shrews. Nature 179 60 PMID: 23953843


Do you know of a great paper that uses CP 99994 dihydrochloride from Tocris? If so please let us know.

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