CP 99994 dihydrochloride
High affinity NK1 antagonist (Ki = 0.145 nM in vitro). Also displays high ex vivo binding potency in gerbil striatum (IC50 = 36.8 nM). Attenuates endothelium-dependent contraction induced by substance P.
Sold for research purposes under agreement from Pfizer Inc.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 369.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.71 mL||13.54 mL||27.08 mL|
|5 mM||0.54 mL||2.71 mL||5.42 mL|
|10 mM||0.27 mL||1.35 mL||2.71 mL|
|50 mM||0.05 mL||0.27 mL||0.54 mL|
References are publications that support the products' biological activity.
Shirahase et al (1995) Endothelium-dependent contraction in intrapulmonary arteries: mediation by endothelial NK1 receptors and TXA2. Br.J.Pharmacol. 115 1215 PMID: 7582548
Duffy et al (2002) Correlation of neurokinin (NK) 1 receptor occupancy in gerbil striatum with behavioral effects of NK1 antagonists. J.Pharmacol.Exp.Ther. 301 536 PMID: 11961054
Lindstrom et al (2007) Neurokinin 1 receptor antagonists: correlation between in vitro receptor interaction and in vivo efficacy. J.Pharmacol.Exp.Ther. 322 1286 PMID: 17575073
If you know of a relevant reference for CP 99994 dihydrochloride, please let us know.
View Related Products by Product Action
Keywords: CP 99994 dihydrochloride, supplier, pfizer, CP99994, neurokinin, 1, receptors, nk1, tachykinin, substance, p, antagonists, NK1, Receptor, NK1, Receptor, Tocris Bioscience
1 Citation for CP 99994 dihydrochloride
Citations are publications that use Tocris products. Selected citations for CP 99994 dihydrochloride include:
Horn et al (2013) Novel dynamic measures of emetic behavior in musk shrews. Nature 179 60 PMID: 23953843
Do you know of a great paper that uses CP 99994 dihydrochloride from Tocris? If so please let us know.
Reviews for CP 99994 dihydrochloride
There are currently no reviews for this product. Be the first to review CP 99994 dihydrochloride and earn rewards!
Have you used CP 99994 dihydrochloride?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and EuropeSubmit a Review
Literature in this Area
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.