CP 96345

Pricing Availability   Qty
Cat.No. 2893 - CP 96345 | C28H32N2O | CAS No. 132746-60-2
Description: Potent and selective NK1 antagonist
Chemical Name: (2S,3S)-N-(2-Methoxyphenyl)methyl-2-diphenylmethyl-1-azabicyclo[2.2.2]octan-3-amine
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (6)

Biological Activity

Potent and selective non-peptide NK1 receptor antagonist. Attenuates substance P-induced salivary response and inhibits neurogenic inflammation in vivo.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

CP 96345 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 412.57
Formula C28H32N2O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 132746-60-2
PubChem ID 104943
InChI Key FLNYLINBEZROPL-NSOVKSMOSA-N
Smiles COC(C=CC=C3)=C3CN[C@H]1C(CC4)CCN4[C@H]1[C@H](C5=CC=CC=C5)C2=CC=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.25 20 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 412.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 12.12 mL 60.6 mL 121.19 mL
1 mM 2.42 mL 12.12 mL 24.24 mL
2 mM 1.21 mL 6.06 mL 12.12 mL
10 mM 0.24 mL 1.21 mL 2.42 mL

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References

References are publications that support the biological activity of the product.

Snider et al (1991) A potent nonpeptide antagonist of the substance P (NK1) receptor. Science 251 435 PMID: 1703323

Lembeck et al (1992) The non-peptide tachykinin antagonist, CP-96,345, is a potent inhibitor of neurogenic inflammation. Br.J.Pharmacol. 105 527 PMID: 1378337

Bang et al (2003) Neurokinin-1 receptor antagonists CP-96,345 and L-733,060 protect mice from cytokine-mediated liver injury. J.Pharmacol.Exp.Ther. 305 31 PMID: 12649350


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Keywords: CP 96345, CP 96345 supplier, Potent, selective, nonpeptide, NK1, receptors, antagonists, tachykinin, neurokinin, CP96345, Pfizer, Receptor, 2893, Tocris Bioscience

1 Citation for CP 96345

Citations are publications that use Tocris products. Selected citations for CP 96345 include:

Silva et al (2015) Spinal blockage of P/Q- or N-type voltage-gated calcium channels modulates functional and symptomatic changes related to haemorrhagic cystitis in mice. Br J Pharmacol 172 924 PMID: 25298144


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