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Potent and selective non-peptide NK1 receptor antagonist. Attenuates substance P-induced salivary response and inhibits neurogenic inflammation in vivo.
Sold for research purposes under agreement from Pfizer Inc.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||8.25||20 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 412.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||12.12 mL||60.6 mL||121.19 mL|
|1 mM||2.42 mL||12.12 mL||24.24 mL|
|2 mM||1.21 mL||6.06 mL||12.12 mL|
|10 mM||0.24 mL||1.21 mL||2.42 mL|
References are publications that support the biological activity of the product.
Snider et al (1991) A potent nonpeptide antagonist of the substance P (NK1) receptor. Science 251 435 PMID: 1703323
Lembeck et al (1992) The non-peptide tachykinin antagonist, CP-96,345, is a potent inhibitor of neurogenic inflammation. Br.J.Pharmacol. 105 527 PMID: 1378337
Bang et al (2003) Neurokinin-1 receptor antagonists CP-96,345 and L-733,060 protect mice from cytokine-mediated liver injury. J.Pharmacol.Exp.Ther. 305 31 PMID: 12649350
If you know of a relevant reference for CP 96345, please let us know.
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Keywords: CP 96345, CP 96345 supplier, Potent, selective, nonpeptide, NK1, receptors, antagonists, tachykinin, neurokinin, CP96345, Pfizer, Receptor, 2893, Tocris Bioscience
1 Citation for CP 96345
Citations are publications that use Tocris products. Selected citations for CP 96345 include:
Silva et al (2015) Spinal blockage of P/Q- or N-type voltage-gated calcium channels modulates functional and symptomatic changes related to haemorrhagic cystitis in mice. Br J Pharmacol 172 924 PMID: 25298144
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.