CP 96345

Pricing Availability   Qty
Description: Potent and selective NK1 antagonist
Chemical Name: (2S,3S)-N-(2-Methoxyphenyl)methyl-2-diphenylmethyl-1-azabicyclo[2.2.2]octan-3-amine
Purity: ≥98% (HPLC)
Citations (1)
Literature (2)

Biological Activity for CP 96345

CP 96345 is a potent and selective non-peptide NK1 receptor antagonist. Attenuates substance P-induced salivary response and inhibits neurogenic inflammation in vivo.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for CP 96345

CP 96345 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CP 96345

M. Wt 412.57
Formula C28H32N2O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 132746-60-2
PubChem ID 104943
Smiles COC(C=CC=C3)=C3CN[C@H]1C(CC4)CCN4[C@H]1[C@H](C5=CC=CC=C5)C2=CC=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CP 96345

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 8.25 20 with gentle warming

Preparing Stock Solutions for CP 96345

The following data is based on the product molecular weight 412.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 12.12 mL 60.6 mL 121.19 mL
1 mM 2.42 mL 12.12 mL 24.24 mL
2 mM 1.21 mL 6.06 mL 12.12 mL
10 mM 0.24 mL 1.21 mL 2.42 mL

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References for CP 96345

References are publications that support the biological activity of the product.

Snider et al (1991) A potent nonpeptide antagonist of the substance P (NK1) receptor. Science 251 435 PMID: 1703323

Lembeck et al (1992) The non-peptide tachykinin antagonist, CP-96,345, is a potent inhibitor of neurogenic inflammation. Br.J.Pharmacol. 105 527 PMID: 1378337

Bang et al (2003) Neurokinin-1 receptor antagonists CP-96,345 and L-733,060 protect mice from cytokine-mediated liver injury. J.Pharmacol.Exp.Ther. 305 31 PMID: 12649350

If you know of a relevant reference for CP 96345, please let us know.

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Keywords: CP 96345, CP 96345 supplier, Potent, selective, nonpeptide, NK1, receptors, antagonists, tachykinin, neurokinin, CP96345, Pfizer, Receptor, 2893, Tocris Bioscience

1 Citation for CP 96345

Citations are publications that use Tocris products. Selected citations for CP 96345 include:

Silva et al (2015) Spinal blockage of P/Q- or N-type voltage-gated calcium channels modulates functional and symptomatic changes related to haemorrhagic cystitis in mice. Br J Pharmacol 172 924 PMID: 25298144

Do you know of a great paper that uses CP 96345 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.