Potent and selective non-peptide NK1 receptor antagonist. Attenuates substance P-induced salivary response and inhibits neurogenic inflammation in vivo.
Sold for research purposes under agreement from Pfizer Inc.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||8.25||20mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 412.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.42 mL||12.12 mL||24.24 mL|
|5 mM||0.48 mL||2.42 mL||4.85 mL|
|10 mM||0.24 mL||1.21 mL||2.42 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
References are publications that support the products' biological activity.
Snider et al (1991) A potent nonpeptide antagonist of the substance P (NK1) receptor. Science 251 435 PMID: 1703323
Lembeck et al (1992) The non-peptide tachykinin antagonist, CP-96,345, is a potent inhibitor of neurogenic inflammation. Br.J.Pharmacol. 105 527 PMID: 1378337
Bang et al (2003) Neurokinin-1 receptor antagonists CP-96,345 and L-733,060 protect mice from cytokine-mediated liver injury. J.Pharmacol.Exp.Ther. 305 31 PMID: 12649350
If you know of a relevant reference for CP 96345, please let us know.
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Keywords: CP 96345, supplier, Potent, selective, nonpeptide, NK1, receptors, antagonists, tachykinin, neurokinin, CP96345, Pfizer, NK1, Receptor, NK1, Receptor, Tocris Bioscience
1 Citation for CP 96345
Citations are publications that use Tocris products. Selected citations for CP 96345 include:
Silva et al (2015) Spinal blockage of P/Q- or N-type voltage-gated calcium channels modulates functional and symptomatic changes related to haemorrhagic cystitis in mice. Br J Pharmacol 172 924 PMID: 25298144
Do you know of a great paper that uses CP 96345 from Tocris? If so please let us know.
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