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Submit ReviewCP 775146
Description: Selective, high affinity PPARα agonist
Chemical Name: 2-Methyl-2-[3-[(3S)-1-[2-[4-(1-methylethyl)phenyl]acetyl]-3-piperidinyl]phenoxy]-propanoic acid
Purity: ≥99% (HPLC)
Biological Activity for CP 775146
CP 775146 is a selective, high affinity PPARα agonist (Ki values are 24.5 nM for PPARα and >10 μM for PPARβ and PPARγ in vitro). Exhibits hypolipidemic activity in vivo.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Compound Libraries for CP 775146
CP 775146 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for CP 775146
| M. Wt | 423.54 |
| Formula | C26H33NO4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 702680-17-9 |
| PubChem ID | 10410059 |
| InChI Key | OISHBINQIFNIPV-JOCHJYFZSA-N |
| Smiles | O=C(CC3=CC=C(C(C)C)C=C3)N(C2)CCC[C@H]2[C@@]1=CC(OC(C)(C)C(O)=O)=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for CP 775146
References for CP 775146
References are publications that support the biological activity of the product.
Kane et al (2009) Molecular characterization of novel and selective peroxisome proliferator-activated receptor α agonists with robust hypolipidemic activity in vivo. Mol.Pharmacol. 75 296 PMID: 18971326
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1 Citation for CP 775146
Citations are publications that use Tocris products. Selected citations for CP 775146 include:
Nagiec et al (2015) Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression. Hum Mol Genet 10 e0120295 PMID: 25811180
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