CP 775146

Pricing Availability   Qty
Description: Selective, high affinity PPARα agonist
Chemical Name: 2-Methyl-2-[3-[(3S)-1-[2-[4-(1-methylethyl)phenyl]acetyl]-3-piperidinyl]phenoxy]-propanoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews

Biological Activity for CP 775146

CP 775146 is a selective, high affinity PPARα agonist (Ki values are 24.5 nM for PPARα and >10 μM for PPARβ and PPARγ in vitro). Exhibits hypolipidemic activity in vivo.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for CP 775146

CP 775146 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for CP 775146

M. Wt 423.54
Formula C26H33NO4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 702680-17-9
PubChem ID 10410059
InChI Key OISHBINQIFNIPV-JOCHJYFZSA-N
Smiles O=C(CC3=CC=C(C(C)C)C=C3)N(C2)CCC[C@H]2[C@@]1=CC(OC(C)(C)C(O)=O)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CP 775146

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.35 100

Preparing Stock Solutions for CP 775146

The following data is based on the product molecular weight 423.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.36 mL 11.81 mL 23.61 mL
5 mM 0.47 mL 2.36 mL 4.72 mL
10 mM 0.24 mL 1.18 mL 2.36 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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References for CP 775146

References are publications that support the biological activity of the product.

Kane et al (2009) Molecular characterization of novel and selective peroxisome proliferator-activated receptor α agonists with robust hypolipidemic activity in vivo. Mol.Pharmacol. 75 296 PMID: 18971326


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Keywords: CP 775146, CP 775146 supplier, pfizer, CP775146, pparalpha, ppara, pparα, peroxisome, proliferator-activated, receptors, agonists, selective, hypolipidemic, hypolipidaemic, PPARalpha, Receptors, 4190, Tocris Bioscience

1 Citation for CP 775146

Citations are publications that use Tocris products. Selected citations for CP 775146 include:

Nagiec et al (2015) Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression. Hum Mol Genet 10 e0120295 PMID: 25811180


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