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Broad spectrum MMP inhibitor (IC50 values are 0.7, 0.9, 13, 16 and 1170 nM for MMP-2, MMP-13, MMP-9, MMP-3 and MMP-1 respectively). Attenuates early left ventricular dilation after experimental myocardial infarction in mice.
Sold for research purposes under agreement from Pfizer Inc.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 368.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.71 mL||13.57 mL||27.15 mL|
|5 mM||0.54 mL||2.71 mL||5.43 mL|
|10 mM||0.27 mL||1.36 mL||2.71 mL|
|50 mM||0.05 mL||0.27 mL||0.54 mL|
References are publications that support the biological activity of the product.
Rohde et al (1999) Matrix metalloproteinease inhibition attenuates early left ventricular enlargement after experimental myocardial infarction in mice. Circulation 99 3063 PMID: 10368126
Lindsey et al (2002) Selective matrix metalloproteinase inhibition reduces left ventricular remodeling but does not inhibit angiogenesis after myocardial infarction. Circulation 105 753 PMID: 11839633
Fang et al (2007) Differences in inflammation, MMP activation and collagen damage account for gender difference in murine cardiac rupture following myocardial infarction. J.Mol.Cell.Cardiol. 43 535 PMID: 17689559
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Keywords: CP 471474, CP 471474 supplier, CP471474, MMP, matrix, metalloproteinase, metalloprotease, inhibitors, inhibits, broad, spectrum, proteinases, proteases, Pfizer, Matrix, Metalloprotease, 3780, Tocris Bioscience
3 Citations for CP 471474
Citations are publications that use Tocris products. Selected citations for CP 471474 include:
Meierjohann et al (2010) MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation. Mol Cancer 9 201 PMID: 20667128
Brafman et al (2013) Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions. PLoS One 20 369 PMID: 23154389
Zariffard et al (2015) Cleavage/Alteration of interleukin-8 by matrix metalloproteinase-9 in the female lower genital tract. PLoS One 10 e0116911 PMID: 25611319
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