CP 471474

Pricing Availability Delivery Time Qty
Cat.No. 3780 - CP 471474 | C16H17FN2O5S | CAS No. 210755-45-6
Description: Broad spectrum MMP inhibitor
Chemical Name: 2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methylpropanamide
Purity: ≥97% (HPLC)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Broad spectrum MMP inhibitor (IC50 values are 0.7, 0.9, 13, 16 and 1170 nM for MMP-2, MMP-13, MMP-9, MMP-3 and MMP-1 respectively). Attenuates early left ventricular dilation after experimental myocardial infarction in mice.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

CP 471474 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 368.38
Formula C16H17FN2O5S
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 210755-45-6
PubChem ID 9907286
InChI Key QCOQJYRPDUMCNP-UHFFFAOYSA-N
Smiles FC1=CC=C(OC2=CC=C(S(NC(C)(C)C(NO)=O)(=O)=O)C=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.84 100

Preparing Stock Solutions

The following data is based on the product molecular weight 368.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.71 mL 13.57 mL 27.15 mL
5 mM 0.54 mL 2.71 mL 5.43 mL
10 mM 0.27 mL 1.36 mL 2.71 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Rohde et al (1999) Matrix metalloproteinease inhibition attenuates early left ventricular enlargement after experimental myocardial infarction in mice. Circulation 99 3063 PMID: 10368126

Lindsey et al (2002) Selective matrix metalloproteinase inhibition reduces left ventricular remodeling but does not inhibit angiogenesis after myocardial infarction. Circulation 105 753 PMID: 11839633

Fang et al (2007) Differences in inflammation, MMP activation and collagen damage account for gender difference in murine cardiac rupture following myocardial infarction. J.Mol.Cell.Cardiol. 43 535 PMID: 17689559


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Keywords: CP 471474, supplier, CP471474, MMP, matrix, metalloproteinase, metalloprotease, inhibitors, inhibits, broad, spectrum, proteinases, proteases, Pfizer, Matrix, Metalloprotease, Matrix, Metalloprotease, Tocris Bioscience

2 Citations for CP 471474

Citations are publications that use Tocris products. Selected citations for CP 471474 include:

Zariffard et al (2015) Cleavage/Alteration of interleukin-8 by matrix metalloproteinase-9 in the female lower genital tract. PLoS One 10 e0116911 PMID: 25611319

Brafman et al (2013) Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions. PLoS One 20 369 PMID: 23154389


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