CP 339818 hydrochloride

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Cat.No. 1399 - CP 339818 hydrochloride | C21H24N2.HCl | CAS No. 478341-55-8
Description: Non-peptide, potent KV1.3 channel blocker
Chemical Name: N-[1-(Phenylmethyl)-4(1H)-quinolinylidene]-1 pentanamine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Potent, non-peptide KV1.3 channel antagonist that preferentially binds to the C-type inactivated state of the channel (IC50 ~ 200 nM). Inhibits KV1.4 with an IC50 of ~ 300 nM. Selective over KV1.1, KV1.2, KV1.5, KV1.6, KV3.1-4, and KV4.2.

Technical Data

M. Wt 340.89
Formula C21H24N2.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 478341-55-8
PubChem ID 20761468
InChI Key JIRISCAPZWLWCG-UHFFFAOYSA-N
Smiles CCCCC\N=C2C1=CC=CC=C1N(CC3=CC=CC=C3)C=C/2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 20 mM in water

References

References are publications that support the biological activity of the product.

Jager et al (1998) Regulation of mammalian Shaker-related K+ channels: evidence for non-conducting closed and non-conducting inactivated. J.Physiol. 506 291 PMID: 9490854

Nguyen et al (1996) Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation. Mol.Pharmacol. 50 1672 PMID: 8967992


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1 Citation for CP 339818 hydrochloride

Citations are publications that use Tocris products. Selected citations for CP 339818 hydrochloride include:

Meredith et al (2015) Kv1 channels and neural processing in vestibular calyx afferents. J Neurosci 9 85 PMID: 26082693


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Literature in this Area

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