CP 135807

Pricing Availability Delivery Time Qty
Cat.No. 3783 - CP 135807 | C19H21N5O2 | CAS No. 151272-90-1
Description: Selective 5-HT1D agonist
Chemical Name: 3-[[(2R)-1-Methyl-2-pyrrolidinyl]methyl]-N-(3-nitro-2-pyridinyl)-1H-indol-5-amine
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective 5-HT1D receptor agonist. Produces dose-dependent decreases in extracellular 5-HT concentration.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 351.4
Formula C19H21N5O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 151272-90-1
PubChem ID 5487088
InChI Key YPFIYPNOWVPAPR-OAHLLOKOSA-N
Smiles CN(CCC4)[C@H]4CC1=CNC2=C1C=C(NC3=NC=CC=C3[N+]([O-])=O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.14 100

Preparing Stock Solutions

The following data is based on the product molecular weight 351.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.23 mL 28.46 mL
5 mM 0.57 mL 2.85 mL 5.69 mL
10 mM 0.28 mL 1.42 mL 2.85 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Hertel et al (1999) The antipsychotic drug risperidone interacts with auto- and hetero-receptors regulating serotonin output in the rat frontal cortex. Neuropharmacology 38 1175 PMID: 10462130

Mansbach et al (1996) CP-135,807, a selective 5-HT1D agonist: effects in drug discrimination and punishment procedures in the pigeon. Psychopharmacology 128 313 PMID: 8972551

Rollema et al (1996) Combined administration of a 5-hydroxytryptamine (5-HT)1D antagonist and a 5-HT reuptake inhibitor synergistically increases 5-HT release in guinea pig hypothalamus in vivo. J.Neurochem. 67 2204 PMID: 8863532


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Keywords: selective 5-HT serotonin 5-HT1D receptors agonists Pfizer CP135807 5-HT1D Receptors

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Literature in this Area

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

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5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

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