CP 122721 hydrochloride

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Cat.No. 3649 - CP 122721 hydrochloride | C20H23F3N2O2.2HCl | CAS No. 145877-52-7
Description: High affinity NK1 receptor antagonist
Chemical Name: (2S,3S)-N-[[2-Methoxy-5-(trifluoromethoxy)phenyl]methyl]-2-phenyl-3-piperidinamine dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

High affinity NK1 antagonist (pIC50 = 9.8). Suppresses recruitment of immunocytes in respiratory syncytial virus (RSV)-infected rats after capsaicin stimulation. Also blocks substance P-induced excitation of locus ceruleus cells in guinea pig brain slices (IC50 = 7 nM). Exhibits anxiolytic and antidepressant-like effects. Active in vivo.

Technical Data

M. Wt 453.33
Formula C20H23F3N2O2.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 145877-52-7
PubChem ID 90664465
InChI Key AVTRGAPFNJEOTQ-FFUVTKDNSA-N
Smiles Cl.Cl.COC1=C(CN[C@H]2CCCN[C@H]2C2=CC=CC=C2)C=C(OC(F)(F)F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.33 100
water 45.33 100

Preparing Stock Solutions

The following data is based on the product molecular weight 453.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.21 mL 11.03 mL 22.06 mL
5 mM 0.44 mL 2.21 mL 4.41 mL
10 mM 0.22 mL 1.1 mL 2.21 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

McLean et al (1996) Characterization of CP-122,721; a nonpeptide antagonist of the neurokinin NK1 receptor. J.Pharmacol.Exp.Ther. 277 900 PMID: 8627572

Gonsalves et al (1996) Broad spectrum antiemetic effects of CP-122,721, a tachykinin NK1 receptor antagonist, in ferrets. Eur.J.Pharmacol. 305 181 PMID: 8813551

Auais et al (2003) Immunomodulatory effects of sensory nerves during respiratory syncytial virus infection in rats. Am.J.Physiol. Lung Cell Mol.Physiol. 285 L105 PMID: 12639840


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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