(-)-Cotinine

Discontinued Product

(-)-Cotinine (Cat. No. 3110) has been withdrawn from sale for commercial reasons.
Cat.No. 3110 - Cotinine | C10H12N2O | CAS No. 486-56-6
Description: Major metabolite of nicotine
Chemical Name: (S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity

Major metabolite of nicotine. Shown to activate a subpopulation of α3/α6β2 nAChRs in monkey striatum. Displays cognition-enhancing effects in vivo; reduces amyloid β (Aβ) aggregation and improves memory in an Alzheimer's disease mouse model.

Technical Data

M. Wt 176.22
Formula C10H12N2O
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 486-56-6
PubChem ID 854019
InChI Key UIKROCXWUNQSPJ-VIFPVBQESA-N
Smiles CN(C(CC2)=O)[C@@H]2[C@]1=CC=CN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

References

References are publications that support the biological activity of the product.

Buccafusco and Terry (2003) The potential role of cotinine in the cognitive and neuroprotective actions of nicotine. Life Sci. 72 2931 PMID: 12706481

Terry et al (2005) Cotinine, a neuroactive metabolite of nicotine: potential for treating disorders of impaired cognition. CNS Drug Rev. 11 229 PMID: 16389292

O'Leary et al (2008) Cotinine selectively activates a subpopulation of α3/α6β2 nicotinic receptors in monkey striatum. 325 646 PMID: 18305015

Echeverria et al (2011) Cotinine reduces amyloid-β aggregation and improves memory in Alzheimer's disease mice. J.Alzheimers Dis. 23 1 PMID: 20930295

View Related Products by Product Action

View all Nicotinic Receptor (Non-selective) Agonists

Keywords: Cotinine, Cotinine supplier, metabolite, nicotine, Acetylcholine, Nicotinic, Receptors, Non-Selective, Subtypes, nAChR, (Non-selective), 3110, Tocris Bioscience

Citations for (-)-Cotinine

Citations are publications that use Tocris products.

Currently there are no citations for (-)-Cotinine.

Reviews for (-)-Cotinine

There are currently no reviews for this product. Be the first to review (-)-Cotinine and earn rewards!

Have you used (-)-Cotinine?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Pain

Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Nicotinic ACh Receptors

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.

Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.