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Submit ReviewCorynanthine hydrochloride
Discontinued Product
Corynanthine hydrochloride (Cat. No. 1143) has been withdrawn from sale for commercial reasons.
Description: α1 antagonist
Chemical Name: (16b,17a)-17-Hydroxy-yohimban-16-carboxylic acid methyl ester hydrochloride
Biological Activity for Corynanthine hydrochloride
α1-adrenoceptor selective antagonist.
Technical Data for Corynanthine hydrochloride
| M. Wt | 390.91 |
| Formula | C21H26N2O3.HCl |
| Storage | Desiccate at +4°C |
| CAS Number | 66634-44-4 |
| Smiles | COC(C1C2C(CCC1O)CN1CCc3c4ccccc4[nH]c3C1C2)=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Corynanthine hydrochloride
References for Corynanthine hydrochloride
References are publications that support the biological activity of the product.
Doxey et al (1984) Comparison of the alpha-adrenoceptor antagonist profiles of idazoxan (RX 781094), yohimbine, rauwolscine and corynanthine. Naunyn Schmiedebergs Arch.Pharmacol. 325 136 PMID: 6144048
Hertting and Jackisch (1985) Endogenous noradrenaline as modulator of hippocampal serotonin (5-HT)-release. Dual effects of yohimbine, rauwolscine and corynanthine as alpha-adrenoceptor antagonists and 5-HT receptor agonists. Naunyn Schmiedebergs Arch.Pharmacol. 329 216 PMID: 2991775
Sheppard et al (1981) Pre- and postsynaptic alpha adrenoceptor selectivity studies with yohimbine and its two diastereoisomers rauwolscine and corynanthine in the anesthetized dog. J.Pharmacol.Exp.Ther. 219 540 PMID: 6270312
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Literature in this Area
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.