Corynanthine hydrochloride

Discontinued Product

Unfortunately Corynanthine hydrochloride (Cat. No. 1143) has been withdrawn from sale for commercial reasons.
Cat.No. 1143 - Corynanthine hydrochloride | C21H26N2O3.HCl | CAS No. 66634-44-4
Chemical Name: (16b,17a)-17-Hydroxy-yohimban-16-carboxylic acid methyl ester hydrochloride

Biological Activity

α1-adrenoceptor selective antagonist.

Technical Data

M. Wt 390.91
Formula C21H26N2O3.HCl
Storage Desiccate at +4°C
CAS Number 66634-44-4
Smiles COC(C1C2C(CCC1O)CN1CCc3c4ccccc4[nH]c3C1C2)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 390.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.56 mL 12.79 mL 25.58 mL
5 mM 0.51 mL 2.56 mL 5.12 mL
10 mM 0.26 mL 1.28 mL 2.56 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Doxey et al (1984) Comparison of the alpha-adrenoceptor antagonist profiles of idazoxan (RX 781094), yohimbine, rauwolscine and corynanthine. Naunyn Schmiedebergs Arch.Pharmacol. 325 136 PMID: 6144048

Hertting and Jackisch (1985) Endogenous noradrenaline as modulator of hippocampal serotonin (5-HT)-release. Dual effects of yohimbine, rauwolscine and corynanthine as alpha-adrenoceptor antagonists and 5-HT receptor agonists. Naunyn Schmiedebergs Arch.Pharmacol. 329 216 PMID: 2991775

Sheppard et al (1981) Pre- and postsynaptic alpha adrenoceptor selectivity studies with yohimbine and its two diastereoisomers rauwolscine and corynanthine in the anesthetized dog. J.Pharmacol.Exp.Ther. 219 540 PMID: 6270312


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