Corynanthine hydrochloride

Discontinued Product

Corynanthine hydrochloride (Cat. No. 1143) has been withdrawn from sale for commercial reasons.
Description: α1 antagonist
Chemical Name: (16b,17a)-17-Hydroxy-yohimban-16-carboxylic acid methyl ester hydrochloride
Literature (1)

Biological Activity for Corynanthine hydrochloride

α1-adrenoceptor selective antagonist.

Technical Data for Corynanthine hydrochloride

M. Wt 390.91
Formula C21H26N2O3.HCl
Storage Desiccate at +4°C
CAS Number 66634-44-4
Smiles COC(C1C2C(CCC1O)CN1CCc3c4ccccc4[nH]c3C1C2)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Corynanthine hydrochloride

Certificate of Analysis / Product Datasheet
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References for Corynanthine hydrochloride

References are publications that support the biological activity of the product.

Doxey et al (1984) Comparison of the alpha-adrenoceptor antagonist profiles of idazoxan (RX 781094), yohimbine, rauwolscine and corynanthine. Naunyn Schmiedebergs Arch.Pharmacol. 325 136 PMID: 6144048

Hertting and Jackisch (1985) Endogenous noradrenaline as modulator of hippocampal serotonin (5-HT)-release. Dual effects of yohimbine, rauwolscine and corynanthine as alpha-adrenoceptor antagonists and 5-HT receptor agonists. Naunyn Schmiedebergs Arch.Pharmacol. 329 216 PMID: 2991775

Sheppard et al (1981) Pre- and postsynaptic alpha adrenoceptor selectivity studies with yohimbine and its two diastereoisomers rauwolscine and corynanthine in the anesthetized dog. J.Pharmacol.Exp.Ther. 219 540 PMID: 6270312

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Citations for Corynanthine hydrochloride

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Currently there are no citations for Corynanthine hydrochloride.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.