Corynanthine hydrochloride

Cat. No. 1143 Datasheet / COA / SDS

Discontinued Product

Unfortunately Corynanthine hydrochloride (Cat. No. 1143) has been withdrawn from sale for commercial reasons.
Cat.No. 1143 - Corynanthine hydrochloride | C21H26N2O3.HCl | CAS No. 66634-44-4
Description: α1 antagonist
Chemical Name: (16b,17a)-17-Hydroxy-yohimban-16-carboxylic acid methyl ester hydrochloride
Datasheet
Citations
Reviews
Literature

Biological Activity

α1-adrenoceptor selective antagonist.

Technical Data

M. Wt 390.91
Formula C21H26N2O3.HCl
Storage Desiccate at +4°C
CAS Number 66634-44-4
Smiles COC(C1C2C(CCC1O)CN1CCc3c4ccccc4[nH]c3C1C2)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Doxey et al (1984) Comparison of the alpha-adrenoceptor antagonist profiles of idazoxan (RX 781094), yohimbine, rauwolscine and corynanthine. Naunyn Schmiedebergs Arch.Pharmacol. 325 136 PMID: 6144048

Hertting and Jackisch (1985) Endogenous noradrenaline as modulator of hippocampal serotonin (5-HT)-release. Dual effects of yohimbine, rauwolscine and corynanthine as alpha-adrenoceptor antagonists and 5-HT receptor agonists. Naunyn Schmiedebergs Arch.Pharmacol. 329 216 PMID: 2991775

Sheppard et al (1981) Pre- and postsynaptic alpha adrenoceptor selectivity studies with yohimbine and its two diastereoisomers rauwolscine and corynanthine in the anesthetized dog. J.Pharmacol.Exp.Ther. 219 540 PMID: 6270312

View Related Products by Target

View Related Products by Product Action

View all Adrenergic α1 Receptor Antagonists

Keywords: Corynanthine hydrochloride, supplier, Adrenergic, Alpha-1, Receptors, Adrenergic, Alpha-1, Receptors, Tocris Bioscience

Citations for Corynanthine hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for Corynanthine hydrochloride.

Reviews for Corynanthine hydrochloride

There are currently no reviews for this product. Be the first to review Corynanthine hydrochloride and earn rewards!

Have you used Corynanthine hydrochloride?

Submit a review and receive an Amazon gift card.

$10US/$10CAN/€7/£6 gift card for a review without an image

$25US/$25CAN/€18/£15 gift card for a review with an image

*Offer only valid in the USA / Canada, UK and Europe

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.