Conessine

Discontinued Product

Conessine (Cat. No. 2409) has been withdrawn from sale for commercial reasons.
Cat.No. 2409 - Conessine | C24H40N2 | CAS No. 546-06-5
Description: Potent and selective H3 receptor antagonist
Chemical Name: N,N-Dimethyl-con-5-enin-3-amine
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective histamine H3 receptor antagonist (pKi values are 7.61 and 8.27 at rat and human H3 receptors respectively). A steroidal alkaloid that displays in vitro antiplasmodial activity (IC50 = 1.04 μM). Also has high affinity for α2C adrenoceptors (pKi = 7.98).

Technical Data

M. Wt 356.59
Formula C24H40N2
Storage Store at RT
CAS Number 546-06-5
PubChem ID 441082
InChI Key GPLGAQQQNWMVMM-MYAJQUOBSA-N
Smiles [H][C@@]23CC=C1C[C@@H](N(C)C)CC[C@@](C)1[C@]([H])2CC[C@@]45[C@]([H])3CC[C@@]([H])4[C@H](C)N(C)C5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Zirihi et al (2005) Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf. Bioorg.Med.Chem.Lett. 15 2637 PMID: 15863333

Zhao et al (2008) The alkaloid conessine and analogues as potent histamine H3 receptor antagonists. J.Med.Chem. 51 5423 PMID: 18683917

Witte et al (2005) Discovery of a novel natural product of unique chemical structure as a potent and selective histamine H3 receptor (H3R) antagonist. Soc.Neurosci.Abstr. 491 19

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Keywords: Conessine, Conessine supplier, Potent, selective, H3, receptor, antagonists, Receptors, Histamine, histaminergic, 2409, Tocris Bioscience

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