Conessine

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Cat.No. 2409 - Conessine | C24H40N2 | CAS No. 546-06-5
Description: Potent and selective H3 receptor antagonist
Chemical Name: N,N-Dimethyl-con-5-enin-3-amine
Datasheet
Citations
Literature

Biological Activity

Potent and selective histamine H3 receptor antagonist (pKi values are 7.61 and 8.27 at rat and human H3 receptors respectively). A steroidal alkaloid that displays in vitro antiplasmodial activity (IC50 = 1.04 μM). Also has high affinity for α2C adrenoceptors (pKi = 7.98).

Technical Data

M. Wt 356.59
Formula C24H40N2
Storage Store at RT
CAS Number 546-06-5
PubChem ID 441082
InChI Key GPLGAQQQNWMVMM-MYAJQUOBSA-N
Smiles [H][C@@]23CC=C1C[C@@H](N(C)C)CC[C@@](C)1[C@]([H])2CC[C@@]45[C@]([H])3CC[C@@]([H])4[C@H](C)N(C)C5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.85 50mM with gentle warming
ethanol 17.85 50

Preparing Stock Solutions

The following data is based on the product molecular weight 356.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.8 mL 14.02 mL 28.04 mL
5 mM 0.56 mL 2.8 mL 5.61 mL
10 mM 0.28 mL 1.4 mL 2.8 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Zirihi et al (2005) Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf. Bioorg.Med.Chem.Lett. 15 2637 PMID: 15863333

Zhao et al (2008) The alkaloid conessine and analogues as potent histamine H3 receptor antagonists. J.Med.Chem. 51 5423 PMID: 18683917

Witte et al (2005) Discovery of a novel natural product of unique chemical structure as a potent and selective histamine H3 receptor (H3R) antagonist. Soc.Neurosci.Abstr. 491 19 PMID:


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Keywords: Conessine, supplier, Potent, selective, H3, receptor, antagonists, Receptors, Histamine, histaminergic, Histamine, H3, Receptors, Tocris Bioscience

Citations for Conessine

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