COG 133

Pricing Availability Delivery Time Qty
Cat.No. 3405 - COG 133 | Ac-Leu-Arg-Val-Arg-Leu-Ala-Ser-His-Leu-Arg-Lys-Leu-Arg-Lys-Arg-Leu-Leu-NH2 | CAS No. 514200-66-9
Description: ApoE peptide fragment
Alternative Names: apoE(133-149)
Datasheet
Citations
Literature

Biological Activity

Apolipoprotein (ApoE) peptide fragment that functions via the low-density lipoprotein receptor-related protein (LRP). Substantially reduces the symptoms of experimental autoimmune encephalomyelitis, a model of human multiple sclerosis, and suppresses inflammation, demyelination and infiltration of cells into the spinal cord. Also acts as a non-competitive antagonist at α7 nicotinic acetylcholine receptors (IC50 = 445 nM).

Technical Data

M. Wt 2169.73
Formula C97H181N37O19
Sequence LRVRLASHLRKLRKRLL

(Modifications: Leu-1 = N-terminal Ac, Leu-17 = C-terminal amide)

Storage Store at -20°C
CAS Number 514200-66-9
PubChem ID 16201427
InChI Key QTWXJKVJIKDSLC-KIZXDXQLSA-N
Smiles CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(C)=O)C(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 2169.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.46 mL 2.3 mL 4.61 mL
5 mM 0.09 mL 0.46 mL 0.92 mL
10 mM 0.05 mL 0.23 mL 0.46 mL
50 mM 0.01 mL 0.05 mL 0.09 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Gay et al (2006) Apolipoprotein E-derived peptides block α7 neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. J.Pharmacol.Exp.Ther. 316 835 PMID: 16249370

Li et al (2006) Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis. J.Pharmacol.Exp.Ther. 318 956 PMID: 16740622

Sheng et al (2008) N-methyl-D-aspartate receptor inhibition by an apolipoprotein E-derived peptide relies on low-density lipoprotein receptor-associated protein. Neuropharmacology 55 204 PMID: 18602124


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Keywords: COG 133, supplier, apoE, peptide, fragment, α7, alpha7, a7, nAChR, antagonists, NMDA, Nicotinic, Receptors, Acetylcholine, Glutamate, N-Methyl-D-Aspartate, iGluR, Ionotropic, COG133, apoE(133149), LDL, lipoprotein, apolipoproteins, apoE(133-149), LDL, Receptors, Tocris Bioscience

Citations for COG 133

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New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
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Pathways for COG 133

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