Co 101244 hydrochloride

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Cat.No. 2456 - Co 101244 hydrochloride | C21H27NO3.HCl | CAS No. 193356-17-1
Description: Highly selective NR2B antagonist
Alternative Names: PD 174494, Ro 63-1908
Chemical Name: 1-[2-(4-Hydroxyphenoxy)ethyl]-4-[(4-methylphenyl)methyl]-4-piperidinol hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Literature

Biological Activity

Novel, potent and selective antagonist of NR2B-containing NMDA receptors (IC50 values are 0.043, > 100 and > 100 μM for NR1A/2B, NR1A/2A and NR1A/2C subunit combinations respectively). Displays neuroprotective effects in vivo and in vitro.

Compound Libraries

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Technical Data

M. Wt 377.91
Formula C21H27NO3.HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 193356-17-1
PubChem ID 6918426
InChI Key WFFZHKKSIDENAJ-UHFFFAOYSA-N
Smiles Cl.CC1=CC=C(CC2(O)CCN(CCOC3=CC=C(O)C=C3)CC2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.9 50
water 37.79 100

Preparing Stock Solutions

The following data is based on the product molecular weight 377.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.65 mL 13.23 mL 26.46 mL
5 mM 0.53 mL 2.65 mL 5.29 mL
10 mM 0.26 mL 1.32 mL 2.65 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Zhou et al (1999) 4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist. J.Med.Chem. 42 2993 PMID: 10425109

Gill et al (2002) Pharmacological characterization of Ro 63-1908 (1-[2-(4-hydroxy-phenoxy)-ethyl]-4-(4-methyl-benzyl)-piperidin-4-ol), a novel subtype-selective N-methyl-D-aspartate antagonist. J.Pharmacol.Exp.Ther. 302 940 PMID: 12183650

Higgins et al (2003) Evaluation of the NR2B-selective NMDA receptor antagonist Ro 63-1908 on rodent behaviour: evidence for an involvement of NR2B NMDA receptors in response inhibition. Neuropharmacology 44 324 PMID: 12604092


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Keywords: Co 101244 hydrochloride, supplier, selective, NR2B, antagonists, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Co101244, hydrochloride, PD174494, Ro63-1908, PD, 174494, Ro, 63-1908, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience

3 Citations for Co 101244 hydrochloride

Citations are publications that use Tocris products. Selected citations for Co 101244 hydrochloride include:

Mirante et al (2014) Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala. Am J Physiol Renal Physiol 7 62 PMID: 25071439

Peng et al (2008) TRPV1 mediates the uterine capsaicin-induced NMDA NR2B-dependent cross-organ reflex sensitization in anesthetized rats. Neuroscience 295 F1324 PMID: 18632800

Quillinan et al (2015) Region-specific role for GluN2B-containing NMDA receptors in injury to Purkinje cells and CA1 neurons following global cerebral ischemia. J Cell Biol 284 555 PMID: 25450957


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