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Biological Activity for CM 11
CM 11 is a PROTAC® for self-degradation of the long form of VHL, pVHL30 (DC50 < 100 nM). Composed of two VHL ligands joined by a linker. Exhibits > 1000-fold increased cellular activity compared to the parent VHL ligand, VH 032. Dimerizes pVHL30 with high avidity in vitro. Induced potent and rapid self-degradation of VHL in cell lines in a highly isoform dependent fashion. Negative control CMP 98 (Cat. No. 6417) also available.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Sold under licence from the University of Dundee
Technical Data for CM 11
|DC50||10-100 nM - Degradation of pVHL30 in HeLa cells after 24 h treatment|
|Selectivity confirmed by global proteomics||No|
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CM 11
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for CM 11
The following data is based on the product molecular weight 1179.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.85 mL||4.24 mL||8.48 mL|
|5 mM||0.17 mL||0.85 mL||1.7 mL|
|10 mM||0.08 mL||0.42 mL||0.85 mL|
|50 mM||0.02 mL||0.08 mL||0.17 mL|
References for CM 11
References are publications that support the biological activity of the product.
Maniaci et al (2017) Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat.Commun. 8 830 PMID: 29018234
If you know of a relevant reference for CM 11, please let us know.
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Keywords: CM 11, CM 11 supplier, CM11, PROTACs, Proteolysis, targeted, chimeras, E3, ubiquitin, ligase, VHL, PROTAC, active, degraders, degrades, protein, degradation, tpd, Ubiquitin, Ligases, Active, Degraders, 6416, Tocris Bioscience
Citations for CM 11
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Reviews for CM 11
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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